The Impact of Ten Days of Periodic Fasting on the Modulation of the Longevity Gene in Overweight and Obese Individuals: A Quasi-Experimental Study

Nutrients, Год журнала: 2024, Номер 16(18), С. 3112 - 3112

Опубликована: Сен. 15, 2024

Background: Fasting potentially alters the aging process induced by obesity regulating telomere integrity, which is related to longevity genes. However, impact of periodic fasting (PF) on expression genes, particularly Forkhead Box O Transcription Factors (FOXO3a) and Human Telomerase Reverse Transcriptase (hTERT), not fully understood. This study aimed analyze effects PF, specifically FOXO3a, hTERT expression, other associated factors. Methods: A quasi-experimental 10-day was conducted in Surabaya, East Java, Indonesia. consisted an intervention group (PFG), carried out PF for ten days using a daily 12 h time-restricted eating protocol, control (CG), had meals as usual. FOXO3a were analyzed quantitative real-time qPCR. paired t-test/Wilcoxon test, independent t-test/Mann–Whitney U-test, Spearman’s correlation test used statistical analysis. Result: Thirty-six young men participated this study. During post-test period, PFG increased 28.56 (±114.05) times compared pre-test, but difference significant. significantly higher both CG PFG. The 10.26 (±8.46) than CG, only 4.73 (±4.81) higher. There also positive relationship between FOXO CG. Conclusions: PFG; however, no significant increase found expression. regimens approach may become potential strategy preventing obesity-induced premature gene

Язык: Английский

Role of Intermittent Fasting In Starving Cancer Cells

Lviv clinical bulletin, Год журнала: 2024, Номер 3 (47), С. 96 - 109

Опубликована: Сен. 30, 2024

Introduction. An absolute burden of over 35 million new cancer cases is predicted by 2050. Although significant progress has been made in the field oncology via use surgical removal, radiation treatment, chemotherapy, and introduction immunotherapy, overall rates survival prognoses for patients are still unsatisfactory. In last decade, intermittent fasting (IF) become increasingly popular weight control potential health benefits. Additionally, research primarily focused on investigating impact IF metabolism, mitochondrial function, stress responses, repair mechanisms, autophagy. The aim study. To make a literature review about role starving cells. Materials methods. This narrative involved comprehensive search through databases such as PubMed Google Scholar. Distinct keywords - ″intermittent fasting″, regimens″, ″calorie restriction″, ″oncology″, ″chemotherapy″ ″tumor microenvironment″ were used. Results. exhibits impacts immune system's ability to fight against tumors strengthening hematopoietic stem cells replenish themselves enhance immunosuppression. Under an program, certain tissues organs exhibit enhanced resilience various stressors. Emerging shows that effectiveness tolerance anticancer medicines, regulate carcinogenic influences, reprogram clock genes' rhythmic expression tumor environments, inhibit growth modifying natural processes like insulin signalling, heme oxygenase-1, prevent proliferation myeloid-derived suppressor priming microenvironment support drug delivery targets tumors. Cancer treatment notably shields normal while raising efficacy chemotherapy (CT) reducing CT-induced inflammation several immunological, biochemical, molecular mechanisms. Conclusions. Regularly practising more than one day may confer notable benefits protecting healthy deleterious effects radiation. synergistic therapeutic alongside suggests it enhances also chemotherapy-induced inflammation. While promise cancers, breast cancer, its other types remains uncertain, necessitating further personalized plans.

Язык: Английский