Analysis of Metabolites in Human Gut: Illuminating the Design of Gut-Targeted Drugs DOI Creative Commons

Alberto Gil-Pichardo,

Andrés Sánchez-Ruiz, Gonzalo Colmenarejo

и другие.

Опубликована: Авг. 21, 2023

Gut-targeted drugs provide a new drug modality besides that of oral, systemic molecules, could tap from the growing knowledge gut metabolites bacterial or host origin and their involvement in biological processes health through interaction with targets (bacterial host, too). Understanding properties can hints for design gut-targeted drugs. In present work we analyze large set metabolites, both shared serum only gut, compare them oral We find patterns specific these two subsets be used to targeting gut. addition, develop openly share Super Learner model predict permanence, order aid molecules appropriate profiles remain resulting putatively reduced secondary effects distribution issues.

Язык: Английский

Analysis of Metabolites in Human Gut: Illuminating the Design of Gut-Targeted Drugs DOI Creative Commons

Alberto Gil-Pichardo,

Andrés Sánchez-Ruiz, Gonzalo Colmenarejo

и другие.

Опубликована: Авг. 21, 2023

Gut-targeted drugs provide a new drug modality besides that of oral, systemic molecules, could tap from the growing knowledge gut metabolites bacterial or host origin and their involvement in biological processes health through interaction with targets (bacterial host, too). Understanding properties can hints for design gut-targeted drugs. In present work we analyze large set metabolites, both shared serum only gut, compare them oral We find patterns specific these two subsets be used to targeting gut. addition, develop openly share Super Learner model predict permanence, order aid molecules appropriate profiles remain resulting putatively reduced secondary effects distribution issues.

Язык: Английский

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