Divergent Synthesis of 17-nor-Cephalotane Diterpenoids through Developed Ynol-diene Cyclization DOI Creative Commons
Zezhong Sun,

Xin Shu,

Fuli Ma

и другие.

Опубликована: Апрель 12, 2024

The diversity of complex molecular structures Cephalotaxus diterpenoids poses great challenges in uncovering the pharmaceutical potential these natural products. As a subfamily diterpenoids, 17-nor-cephalotane possess polycyclic frameworks with seven-membered A ring bearing different oxidation states. On basis novel ynol-diene cyclization developed as rapid access to tropone unit, concise and divergent strategy has been successfully established. Combining bioinspired stereoselective dual hydrogenation, enantioselective total synthesis (+)-3-deoxyfortalpinoid F, (+)-harringtonolide, (−)-fortalpinoids M/N/P, analog (−)-20-deoxycephinoid P have achieved 14-17 linear longest steps starting from commercially available materials.

Язык: Английский

Divergent Synthesis of 17-nor-Cephalotane Diterpenoids through Developed Ynol-diene Cyclization DOI Creative Commons
Zezhong Sun,

Xin Shu,

Fuli Ma

и другие.

Опубликована: Апрель 12, 2024

The diversity of complex molecular structures Cephalotaxus diterpenoids poses great challenges in uncovering the pharmaceutical potential these natural products. As a subfamily diterpenoids, 17-nor-cephalotane possess polycyclic frameworks with seven-membered A ring bearing different oxidation states. On basis novel ynol-diene cyclization developed as rapid access to tropone unit, concise and divergent strategy has been successfully established. Combining bioinspired stereoselective dual hydrogenation, enantioselective total synthesis (+)-3-deoxyfortalpinoid F, (+)-harringtonolide, (−)-fortalpinoids M/N/P, analog (−)-20-deoxycephinoid P have achieved 14-17 linear longest steps starting from commercially available materials.

Язык: Английский

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