A Light-Activated Hypervalent Iodine Agent Enables Diverse Aliphatic C–H Functionalization DOI Creative Commons
Zhipeng Lu, John Putziger, Song Lin

и другие.

Опубликована: Май 30, 2024

The functionalization of aliphatic C–H bonds is a crucial step in the synthesis and transformation complex molecules relevant to medicinal, agricultural, materials chemistry. As such, there significant interest development general synthetic platforms that will enable efficient diversification bonds. Here, we report new hypervalent iodine reagent releases potent hydrogen atom abstractor for activation under mild photochemical conditions. Using this reagent, demonstrate selective (N-phenyltetrazole)thiolation broad scope substrates. utility thiolated products showcased through various derivatizations. Simply by altering radical trapping agent, our method can be used directly transform into diverse functionalities, including C–S, C–Cl, C–Br, C–I, C–O, C–N, C–C

Язык: Английский

A Light-Activated Hypervalent Iodine Agent Enables Diverse Aliphatic C–H Functionalization DOI Creative Commons
Zhipeng Lu, John Putziger, Song Lin

и другие.

Опубликована: Май 30, 2024

The functionalization of aliphatic C–H bonds is a crucial step in the synthesis and transformation complex molecules relevant to medicinal, agricultural, materials chemistry. As such, there significant interest development general synthetic platforms that will enable efficient diversification bonds. Here, we report new hypervalent iodine reagent releases potent hydrogen atom abstractor for activation under mild photochemical conditions. Using this reagent, demonstrate selective (N-phenyltetrazole)thiolation broad scope substrates. utility thiolated products showcased through various derivatizations. Simply by altering radical trapping agent, our method can be used directly transform into diverse functionalities, including C–S, C–Cl, C–Br, C–I, C–O, C–N, C–C

Язык: Английский

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