Опубликована: Авг. 29, 2024

Here, an alcohol-directed 1,2-dicarbofunctionalization of alkenyl alcohols has been realized with aryl/alkenyl boronic acids and alkyl halides as the coupling partners. This reaction was enabled by a commercially available bulky 3-amyl β-diketone (Amacac) ligand, that enhancing reactivity suppressing many competitive processes. With alcohol weak native directing group, this protocol delivers 1,2-arylalkylated 1,2-alkenylalkylated high efficiency, regioselectivities, broad substrate scope, exceptional functional group tolerance. Notably, methodology facilitates modular synthesis biologically active compounds key alcohol-containing synthetic intermediates. Preliminary mechanistic studies shed light on neutral coordination functionality to nickel catalyst origin regioselectivity.

Язык: Английский