Evaluation of anticancer and antimicrobial activities of novel dihydropyrimidinone derivatives DOI Creative Commons
Thangamani Suppan,

RamaRanjan Bhattacharjee,

Moorthi Pichumani

и другие.

Опубликована: Фев. 21, 2024

Dihydropyrimidinone (DHPM) can be synthesized through a simple one-pot Biginelli reaction. Off-late medicinal properties of DHPM have been discovered. In our recent work, we shown that the florescent property appended to this molecule while retaining its therapeutic attributes. derivatives substituted with different alkylating groups like ethyl-, mono-, di-, and tri- ethanol amines. This current paper discusses multifunctionality in form anticancer antimicrobial agent. exhibit improved inhibitory effects vitro assay. The are tested for their anti-cancer on A549 cell lines, as well anti-bacterial anti-fungal clinically significant pathogens Staphylococcus aureus, Methicillin Resistant aureus (MRSA), Escherichia coli, Colistin Pseudomonas aeruginosa, Candida albicans. These discoveries reveal good opportunity develop multifunctional medicine based DHPM. synthesis presence radical moieties supported by chemical studies.

Язык: Английский

Evaluation of anticancer and antimicrobial activities of novel dihydropyrimidinone derivatives DOI Creative Commons
Thangamani Suppan,

RamaRanjan Bhattacharjee,

Moorthi Pichumani

и другие.

Опубликована: Фев. 21, 2024

Dihydropyrimidinone (DHPM) can be synthesized through a simple one-pot Biginelli reaction. Off-late medicinal properties of DHPM have been discovered. In our recent work, we shown that the florescent property appended to this molecule while retaining its therapeutic attributes. derivatives substituted with different alkylating groups like ethyl-, mono-, di-, and tri- ethanol amines. This current paper discusses multifunctionality in form anticancer antimicrobial agent. exhibit improved inhibitory effects vitro assay. The are tested for their anti-cancer on A549 cell lines, as well anti-bacterial anti-fungal clinically significant pathogens Staphylococcus aureus, Methicillin Resistant aureus (MRSA), Escherichia coli, Colistin Pseudomonas aeruginosa, Candida albicans. These discoveries reveal good opportunity develop multifunctional medicine based DHPM. synthesis presence radical moieties supported by chemical studies.

Язык: Английский

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