Artificial molecular motors in biological applications
Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 8, 2025
Molecular
motors
are
the
cornerstone
for
maintenance
of
living
systems
and
mediate
almost
all
fundamental
processes
involved
in
cellular
trafficking.
The
intricate
mechanisms
underlying
natural
molecular
have
been
elucidated
detail,
inspiring
researchers
various
fields
to
construct
artificial
with
multi-domain
applications.
This
review
summarises
characteristics
motors,
biomimetic
approaches
their
design
operation,
recent
biological
Язык: Английский
Photoswitchable Molecular Motor Phospholipid: Synthesis, Characterization, and Integration into Lipid Vesicles
Langmuir,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Lipid
membranes
are
essential
for
cellular
function,
acting
as
barriers
and
platforms
major
biochemical
activities.
The
integration
of
photoisomerizable
units
into
lipid
structures
allows
tunable
membrane
properties,
offering
insights
membrane-related
processes.
In
this
study,
we
present
the
first
molecular-motor-conjugated
phospholipid
system.
synthesis
two
phosphatidylcholine
derivatives
is
reported,
where
one
acyl
chain
replaced
with
a
light-responsive
molecular
rotary
motor
moiety.
We
explore
photochemical
thermodynamic
behaviors
these
compounds
in
solution
self-assembled
systems,
demonstrating
their
rotation
cycles
under
illumination
dynamic
properties
combination
molecules.
Additionally,
giant
unilamellar
vesicles
formed
to
investigate
mechanisms
photoinduced
responses
synthetic
membranes.
Our
findings
show
that
motor-based
lipids
can
operate
aqueous
natural
phospholipids,
maintaining
photoisomerization
enabling
oxidation-driven
release
within
vesicles.
Язык: Английский
Supramolecular polymerization induced by the rotation of light-driven molecular motors
Опубликована: Авг. 16, 2024
Molecular
motors
are
capable
of
producing
mechanical
work
on
their
environment
by
using
unique
capacity
to
generate
non-reciprocal
autonomous
motions
at
the
nanoscale.
Although
operating
principles
now
well
understood,
artificial
molecular
have
yet
demonstrate
general
confer
novel
properties
(supra)molecular
systems
and
materials.
Here
we
show
that
amphiphilic
light-driven
can
adsorb
onto
air-water
interface
form
Langmuir
monolayers
upon
compression.
Under
irradiation,
surface
pressure
isotherms
these
films
reveal
a
drastic
shift
toward
smaller
areas
as
consequence
motors’
activation.
We
explain
this
counterintuitive
phenomenon
rotation-induced
supramolecular
polymerization
motors,
limited
maximal
torque
they
deliver,
leading
formation
highly
organized
patterns.
This
serendipitous
discovery
highlights
opportunities
offered
control
processes
active
nanostructures
for
design
innovative
Язык: Английский