Опубликована: Янв. 5, 2024

Contemporary challenges in chemotherapy for triple negative breast cancer (TNBC) are inadequate specificity towards malignant cells, constraints imposed by dose-related toxicities, and side effects on normal cells. To address these bottlenecks, our study introduces, a drug-free “trojan horse-like” folate functionalized, L-arginine-coated ceria (FA-L-arg-CeO2) nanoplatform treating metastatic TNBC. We show that this engineered nanozyme exhibiting enhanced surface oxygen vacancies (VO●) facilitated band structure reconstruction amplified the photothermal/photodynamic therapeutic (PTT/PDT) efficacy under single laser irradiation (808 nm) through reactive species (ROS) production, thereby outperforming defect-free commercial nano-CeO2 rapid tumour ablation (86% 48 h). This low-cost targeted therapy substantial receptor-mediated endocytosis accumulation of biostable nanozymes MDA-MB-231 cells (84% These VO●-rich FA-L-arg-CeO2 nanostructures were found to exhibit distinctive pH-active multi-enzyme mimicking characteristics, imparting exceptional potential effectively inhibited cell metastasis (62% within 12 Mechanistically, we observed electrons generated at during modulate pH-responsive intracellular redox balance, synergistically killing safeguarding benign L929 Unlike drug-loaded CeO2-based nanoplatforms, protected healthy from radiation damage photo-triggered-ROS scavenging catalase. novel, nanozyme-based leads way smart, bio-inspired multi-modal treatments, ensuring bio-safety.

Язык: Английский