Опубликована: Апрель 23, 2024

Pyridoxal-5'-phosphate (PLP) and derivatives of this cofactor enable a plethora reactions in both enzyme-mediated free-in-solution transformations. With few exceptions each category, such chemistry has predominantly involved two-electron processes. This sometimes poses significant challenge for using PLP to build tetrasubstituted carbon centers, especially when the reaction is reversible. The ability access radical pathways paramount broadening scope catalyzed by coenzyme. In study, we demonstrate PLP-based intermediate engage number C–C bond forming reactions. By selecting an appropriate oxidant, single-electron oxidation quinonoid can be achieved, which subsequently applied Through pathway, synthesized series α-tertiary amino acids esters investigate substrate identify non-productive pathways. Beyond acid model system, that other classes amine substrates range small molecule reagents serve as coupling partner semiquinone radical. We anticipate versatile species will central development novel

Язык: Английский