Опубликована: Июнь 13, 2024

Asymmetric decarboxylative cross-couplings of carboxylic acids represent a powerful tool to synthesize chiral building blocks for medicinal chemistry and material science. However, synthesis versatile alkylboron derivatives via asymmetric C(sp3)-C(sp3) cross-coupling from readily available primary aliphatic mild organometallic reagents is still challenging. In this study, we report visible-light-induced, Ni-catalyzed enantioconvergent unactivated with gem-borazirconocene alkanes, furnishing diverse array valuable blocks. The broad substrate scope, high functional group tolerance, the late-stage modification complex drug molecules natural products enantioselectivity demonstrate synthetic potential method. Mechanistic investigations suggest an radical-radical pathway, wherein radical generated through single-electron reduction ZrIII species, representing unprecedented example enantioselective cross coupling in absence photocatalysts.

Язык: Английский