Опубликована: Авг. 9, 2024

In this work, we present an automated platform designed to facilitate the expedited use of late-stage C-H borylation in fast-moving discovery chemistry projects. Our microscale reaction optimization panel emphasizes regiodivergent nature different protocols and provides a rapid assessment all accessible positions with minimal starting material consumption. The approach taken sustainable tool evaluate conditions targeting multiple bonds. We illustrate workflow by screening numerous fragment-like compounds, drugs agrochemicals demonstrate its practicality successfully isolating 36 derivatives bioactive compounds. Additionally, systematic comparison various catalytic methods using informer library valuable insights regarding desirable future direction research.

Язык: Английский