Total Antioxidant and Oxidative Status as Potential Biomarkers of Alcohol Overdose DOI Open Access
Iwona Ptaszyńska-Sarosiek,

Edyta Gołaś,

Miłosz Nesterowicz

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 82 - 82

Опубликована: Дек. 25, 2024

Serious alcohol-associated hazards underscore the need to develop new biomarkers reflecting biological changes caused by chronic alcohol use and predicting risk of alcohol-related death. Oxidative stress is one mechanism toxicity. The blood urine redox status (total antioxidant capacity [TAC], total oxidative [TOS], index [OSI]) was assessed in 105 people who died a sudden death (controls), 47 overdose, 102 with dependency. TAC TOS were determined utilizing colorimetric method. Non-parametric tests used for statistical analysis. Blood levels significantly elevated individuals both dependency poisoning compared controls. study groups control group, higher patients group poisoning. highly correlated content. Receiver operating characteristic (ROC) analysis showed that effectively discriminated between high sensitivity specificity. Our confirmed impaired homeostasis alcoholism indicated utility TAC, TOS, OSI as exposure.

Язык: Английский

Total Antioxidant and Oxidative Status as Potential Biomarkers of Alcohol Overdose DOI Open Access
Iwona Ptaszyńska-Sarosiek,

Edyta Gołaś,

Miłosz Nesterowicz

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 82 - 82

Опубликована: Дек. 25, 2024

Serious alcohol-associated hazards underscore the need to develop new biomarkers reflecting biological changes caused by chronic alcohol use and predicting risk of alcohol-related death. Oxidative stress is one mechanism toxicity. The blood urine redox status (total antioxidant capacity [TAC], total oxidative [TOS], index [OSI]) was assessed in 105 people who died a sudden death (controls), 47 overdose, 102 with dependency. TAC TOS were determined utilizing colorimetric method. Non-parametric tests used for statistical analysis. Blood levels significantly elevated individuals both dependency poisoning compared controls. study groups control group, higher patients group poisoning. highly correlated content. Receiver operating characteristic (ROC) analysis showed that effectively discriminated between high sensitivity specificity. Our confirmed impaired homeostasis alcoholism indicated utility TAC, TOS, OSI as exposure.

Язык: Английский

Процитировано

0