Glycolysis and beyond in glucose metabolism: exploring pulmonary fibrosis at the metabolic crossroads DOI Creative Commons
Yuejiao Wang, Xue Wang,

Chaoqi Du

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 24, 2024

At present, pulmonary fibrosis (PF) is a prevalent and irreversible lung disease with limited treatment options, idiopathic (IPF) one of its most common forms. Recent research has highlighted PF as metabolic-related disease, including dysregulated iron, mitochondria, lipid, glucose homeostasis. Systematic reports on the regulatory roles metabolism in are rare. This study explores intricate relationships signaling pathways between metabolic processes PF, delving into how key factors involved regulate progression, interplay them. Specifically, we examined various enzymes, such hexokinase (HK), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), pyruvate kinase (PK), lactate dehydrogenase (LDH), illustrating their PF. It highlights significance lactate, alongside role (PDK) transporters (GLUTs) modulating metabolism. Additionally, critical transforming growth factor-beta (TGF-β), interleukin-1 beta (IL-1β), hypoxia-inducible factor 1 subunit alpha (HIF-1α) were discussed, demonstrating impact both pathways. underscores pivotal AMP-activated protein (AMPK) this interplay, drawing connections diabetes mellitus, insulin, insulin-like factors, peroxisome proliferator-activated receptor gamma (PPARγ) emphasizes regulators, fibrogenesis, suggesting potential targeting for clinical diagnosis proposing new promising avenues future therapeutic development.

Язык: Английский

Immune cells crosstalk Pathways, and metabolic alterations in Idiopathic pulmonary fibrosis DOI

Purnima Tiwari,

Shobhit Verma,

Kaveri R. Washimkar

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 135, С. 112269 - 112269

Опубликована: Май 22, 2024

Язык: Английский

Процитировано

8
Glycolysis and beyond in glucose metabolism: exploring pulmonary fibrosis at the metabolic crossroads DOI Creative Commons
Yuejiao Wang, Xue Wang,

Chaoqi Du

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 24, 2024

At present, pulmonary fibrosis (PF) is a prevalent and irreversible lung disease with limited treatment options, idiopathic (IPF) one of its most common forms. Recent research has highlighted PF as metabolic-related disease, including dysregulated iron, mitochondria, lipid, glucose homeostasis. Systematic reports on the regulatory roles metabolism in are rare. This study explores intricate relationships signaling pathways between metabolic processes PF, delving into how key factors involved regulate progression, interplay them. Specifically, we examined various enzymes, such hexokinase (HK), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), pyruvate kinase (PK), lactate dehydrogenase (LDH), illustrating their PF. It highlights significance lactate, alongside role (PDK) transporters (GLUTs) modulating metabolism. Additionally, critical transforming growth factor-beta (TGF-β), interleukin-1 beta (IL-1β), hypoxia-inducible factor 1 subunit alpha (HIF-1α) were discussed, demonstrating impact both pathways. underscores pivotal AMP-activated protein (AMPK) this interplay, drawing connections diabetes mellitus, insulin, insulin-like factors, peroxisome proliferator-activated receptor gamma (PPARγ) emphasizes regulators, fibrogenesis, suggesting potential targeting for clinical diagnosis proposing new promising avenues future therapeutic development.

Язык: Английский

Процитировано

7