Totipotent-like reprogramming: Molecular machineries and chemical manipulations
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research,
Год журнала:
2025,
Номер
1872(3), С. 119925 - 119925
Опубликована: Фев. 22, 2025
Язык: Английский
Ovarian Stem Cells: Will the Dream of Neo-Folliculogenesis After Birth Become Real?
Obstetrical & Gynecological Survey,
Год журнала:
2025,
Номер
80(2), С. 112 - 120
Опубликована: Фев. 1, 2025
Ovarian
stem
cells
(OSCs)
represent
a
promising
tool
in
reproductive
medicine,
particularly
for
the
treatment
of
premature
ovarian
failure
and
fertility
preservation.
Herein,
we
summarize
main
characteristics
adult
cells,
their
status,
needs,
new
challenges
application
medicine.
Clinical
studies
have
shown
that
OSCs
transplantation
can
restore
function
stimulate
neo-folliculogenesis
patients
with
failure,
enabling
them
to
conceive
naturally
or
through
vitro
fertilization
techniques.
Moreover,
gained
increasing
interest
as
chance
preserve
cancer
undergoing
gonadotoxic
treatments
affecting
fertility,
chemotherapy
radiotherapy.
The
recruitment
from
fresh
thawed
fragments
coupled
capability
differentiate
mature
oocytes
could
provide
novel
opportunity
verify
suitability
be
expanded
oocyte
like
cells.
Research
into
applications
medicine
is
still
its
infancy,
but
results
so
far
are
offer
possibilities
suffering
cancer.
Язык: Английский
The explosive discovery of TNT in early mouse embryos
Nature Structural & Molecular Biology,
Год журнала:
2024,
Номер
31(6), С. 852 - 855
Опубликована: Май 24, 2024
Язык: Английский
Embryoids, models, embryos? We need to take a new look at legal norms concerning the beginning of organismic development
Molecular Human Reproduction,
Год журнала:
2023,
Номер
30(1)
Опубликована: Дек. 19, 2023
Язык: Английский
Chromatin structure in totipotent mouse early preimplantation embryos
Journal of Reproduction and Development,
Год журнала:
2024,
Номер
70(3), С. 152 - 159
Опубликована: Янв. 1, 2024
Totipotency
refers
to
the
ability
of
a
single
cell
give
rise
all
different
types
in
body.
Terminally
differentiated
germ
cells
(spermatozoa
and
oocytes)
undergo
reprogramming,
which
results
acquisition
totipotency
zygotes.
Since
1990s,
numerous
studies
have
focused
on
mechanisms
totipotency.
With
emergence
concept
epigenetic
is
important
for
undifferentiated
states
cells,
epigenomes
fertilized
eggs
been
thoroughly
analyzed.
However,
early
immunostaining
studies,
detailed
epigenomic
information
was
difficult
obtain.
In
recent
years,
explosive
development
next-generation
sequencing
has
made
it
possible
acquire
genome-wide
genome
editing
facilitated
analysis
knockout
mice,
previously
difficult.
addition,
live
imaging
can
effectively
analyze
zygotes
2-cell
embryos,
number
samples
limited,
provides
biological
insights
that
cannot
be
obtained
by
other
methods.
this
review,
progress
our
research
using
these
advanced
techniques
traced
back
from
present
its
earliest
years.
Язык: Английский
Use of induced pluripotent stem cells for regenerative medicine and understanding of cell biology
Reproduction Fertility and Development,
Год журнала:
2024,
Номер
37(1)
Опубликована: Дек. 12, 2024
Stem
cells
are
a
highly
desirable
tool
for
regenerative
medicine
due
to
unique
characteristics
such
as
immunomodulation
and
angiogenesis
(multipotent
cells)
high
self-renewal
potential
differentiation
capability
(pluripotent
cells),
thus
being
classified
according
their
stage
of
dedifferentiation
epigenetic
profile.
Apart
from
used
in
vitro
disease
modeling
or
even
vivo
therapies,
pluripotent
stem
valuable
animal
production
breeding
improvement.
In
particular,
the
lack
robustness
ethical
concerns
regarding
embryonic
cells,
induced
(iPSCs)
emerge
new
‘game
changer’
veterinary
translational
medicine.
Herein,
we
present
discuss
recent
uses
understanding
cell
biology,
focusing
on
generating
using
iPSCs
diverse
species
aiming
genetic
conservation
dissemination
gametogenesis,
cellular
agriculture.
Язык: Английский
Stem Cell-Derived Organoids, Embryoids, and Embryos: Advances in Organismic Development In Vitro Force Us to Re-Focus on Ethical and Legal Aspects of Model Choice
Organoids,
Год журнала:
2023,
Номер
2(4), С. 231 - 238
Опубликована: Дек. 5, 2023
While
research
on
stem
cell-derived
tissues
and
organoids
is
rapidly
expanding,
the
technically
related
creation
of
complex
embryoids
has
recently
excited
a
vivid
discussion
since
it
raises
ethical
questions
about
individuation
possible
gain
viability.
The
present
study
focuses
onset
organismic
development
proposed
biological
legal
definitions
for
terms
embryo,
embryoid,
organoid.
It
concluded
that
such
considerations
have
become
important
investigators’
choices
appropriate
in
vitro
model
systems,
allowing
formation
vs.
embryoids.
Язык: Английский