Patient‐derived xenograft model in cancer: establishment and applications

MedComm, Год журнала: 2025, Номер 6(2)

Опубликована: Янв. 19, 2025

Abstract The patient‐derived xenograft (PDX) model is a crucial in vivo extensively employed cancer research that has been shown to maintain the genomic characteristics and pathological structure of patients across various subtypes, metastatic, diverse treatment histories. Various strategies utilized PDX models can offer valuable insights into mechanisms tumor progression, drug resistance, development novel therapies. This review provides comprehensive overview establishment applications models. We present an history current status models, elucidate construction methodologies for different tumors, conduct comparative analysis highlight distinct advantages limitations this relation other are elucidated domain comprehending underlying therapy, which highlights broad fields chemotherapy, targeted delivery systems, combination antibody–drug conjugates radiotherapy. Furthermore, with multiomics single‐cell analyses also emphasized. application clinical personalized medicine additionally

Язык: Английский

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Interventional Effects of Edible Bird’s Nest and Free Sialic Acids on LPS-Induced Brain Inflammation in Mice

Nutrients, Год журнала: 2025, Номер 17(3), С. 531 - 531

Опубликована: Янв. 31, 2025

Objectives: Our study investigated the effects and mechanisms of edible bird's nest (EBN) free sialic acids (SA) on LPS-induced brain inflammation in mice. Methods: The experiment divided mice into four groups: control group (CON), lipopolysaccharide (LPS), EBN intervention (EBN, 200 mg/kg/d dry EBN), acid (SA, dosage was calibrated based concentration EBN). Results: results showed that LPS caused a decrease followed by upregulation body weight female mice, exhibited renal protective effects. In Morris water maze, learning memory abilities first declined then recovered. At same time, escape latency improved SA groups. Open field test, both groups anti-anxiety anti-depressive Immunohistochemistry hippocampus significant cell damage group, while alleviated promoted expression TICAM1 MYD88 NF-κB pathway, could inhibit TICAM1. Conclusions: has found noteworthy anti-inflammatory effects, indicating main active component provides neuroprotective is SA. bound confers additional supporting development prevention treatment strategies for inflammation.

Язык: Английский

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Tetrahydroxy Stilbene Glycoside Reduces Abeta Deposition by Modulating Microglia Activation and via TREM2/PI3K/AKT Pathway in APP/PS1 Mice

Basic & Clinical Pharmacology & Toxicology, Год журнала: 2025, Номер 136(3)

Опубликована: Фев. 13, 2025

Tetrahydroxy stilbene glycoside (TSG), which is the primary active substance of Chinese herbal medicine called Polygonum multiflorum, has been acknowledged to alleviate Alzheimer's disease (AD)-induced learning disorder in transgene mice. Because microglia activation really important during AD progression, herein, we determined effects TSG on neuropathology, polarization and its underlying mechanism. We used APP/PS1 mice along with immunohistochemistry immunofluorescence techniques evaluate function as 60, 120 180 mg/kg Aβ deposition, neuronal loss induced by AD. Additionally, assessed TREM2 signalling using both molecular docking Western blot analysis. was found promote survival decrease deposition Moreover, reduced M1 modulated TREM2/PI3K/AKT pathways. could reduce impairment mediating pathway a latent pharmacological research direction for therapy patients

Язык: Английский

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Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2/NRF2

Phytomedicine, Год журнала: 2025, Номер 140, С. 156623 - 156623

Опубликована: Март 10, 2025

Язык: Английский

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