Patient‐derived xenograft model in cancer: establishment and applications

MedComm, Год журнала: 2025, Номер 6(2)

Опубликована: Янв. 19, 2025

Abstract The patient‐derived xenograft (PDX) model is a crucial in vivo extensively employed cancer research that has been shown to maintain the genomic characteristics and pathological structure of patients across various subtypes, metastatic, diverse treatment histories. Various strategies utilized PDX models can offer valuable insights into mechanisms tumor progression, drug resistance, development novel therapies. This review provides comprehensive overview establishment applications models. We present an history current status models, elucidate construction methodologies for different tumors, conduct comparative analysis highlight distinct advantages limitations this relation other are elucidated domain comprehending underlying therapy, which highlights broad fields chemotherapy, targeted delivery systems, combination antibody–drug conjugates radiotherapy. Furthermore, with multiomics single‐cell analyses also emphasized. application clinical personalized medicine additionally

Язык: Английский

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Unlocking fungal fortunes: Cutting-edge extraction techniques and therapeutic possibilities of mushroom bioactive compounds

Food Chemistry Advances, Год журнала: 2025, Номер unknown, С. 100895 - 100895

Опубликована: Янв. 1, 2025

Язык: Английский

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Polygonatum cyrtonema Hua polysaccharide alleviates ulcerative colitis via gut microbiota-independent modulation of inflammatory immune response

Carbohydrate Polymers, Год журнала: 2025, Номер 356, С. 123387 - 123387

Опубликована: Фев. 16, 2025

Язык: Английский

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Persimmon peel polysaccharides alleviated colitis via regulating gut microbiota and protecting intestinal barrier integrity

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106123 - 106123

Опубликована: Фев. 1, 2025

Язык: Английский

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Glucomannogalactan inhibits senescence by promoting nuclear translocation of NRF2

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 305, С. 141059 - 141059

Опубликована: Фев. 15, 2025

Язык: Английский

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Effects and Mechanisms of Pleurotus eryngii Polysaccharide on Intestinal Barrier Damage: Based on the Perspective of Its Interaction with Intestinal Mucus during Gut Digestion

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

In this study, pathways and mechanisms of action a new type Pleurotus eryngii polysaccharide (PEP) with known structural characteristics probiotic properties in the intestine were investigated. An vitro cell model was used to investigate protective effects complexes formed between PEPs their related products mucin against gut barrier damage. Dextran sulfate sodium salt-induced colitis determine interaction intestinal mucus (IMs) at different consumption times. Finally, effect damage investigated, as mediated by IMs. The result showed that PEP-related improved barrier. exhibited differential functional activities stages. normal mice, interactions IMs characteristics. From transport absorption standpoint, role driving health also clarified study.

Язык: Английский

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Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142985 - 142985

Опубликована: Апрель 1, 2025

Язык: Английский

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Regulating role of Pleurotus ostreatus insoluble dietary fiber in high fat diet induced obesity in rats based on proteomics and metabolomics analyses

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136857 - 136857

Опубликована: Окт. 1, 2024

Язык: Английский

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Vinegar powder exerts immunomodulatory effects through alleviating immune system damage and protecting intestinal integrity and microbiota homeostasis

Food Bioscience, Год журнала: 2024, Номер 63, С. 105687 - 105687

Опубликована: Дек. 12, 2024

Язык: Английский

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Fortification effect of mixed fermentation product of Russula vinosa Lindblad supplementation on physicochemical, sensory and antioxidant properties of wheat bread

Food & medicine homology., Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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