None
Journal of Medicinal and Chemical Sciences,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 3, 2023
Aromatase
inhibitors
(AI)
are
commonly
used
adjuvant
therapy
drugs
for
women
with
hormone
receptor-positive
postmenopausal
breast
cancer.
Frequently
AI
associated
side
effects
include
severe
joint
and
muscle
pain.
Inhibitor
-
Associated
Musculoskeletal
Syndrome
(AIMSS)
is
a
condition
that
primarily
affects
the
hands,
wrists,
knees.
This
study
aimed
to
determine
efficacy
of
Moringa
oleifera
extract
as
an
when
taken
cancer
patients
ER
(+),
PR
observed
CPK
levels
inflammation
indicators.
The
Functional
Assessment
Cancer
Therapy-Breast
(FACT-B)
can
assess
subjects’
emotional,
physical,
functional
well-being,
social,
also
subscale.
research
sample
consisted
40
(+)
immunohistochemistry
outpatients
at
Kasuari
facility,
Dr.
Kariadi
Semarang,
who
experienced
pain
due
administration
aromatase
inhibitors.
results
changes
in
FACT-B
scores
group
received
additional
were
obtained
this
study.
treatment
showed
level
post-test
lower
than
pre-test
(105.30
±
50.19
vs.
88.10
48.24,
p
<0,001).
In
addition,
score
control
(83.45
5.11
75.25
4.05,
p<0,001).
has
strong
anti-inflammatory
effect
especially
patient
post-menopause
inhibitor
treatment.
Its
properties
will
upgrade
patient’s
quality
life,
adherence,
long
period
outcomes.
Язык: Английский
None
Journal of Medicinal and Chemical Sciences,
Год журнала:
2023,
Номер
6(12)
Опубликована: Сен. 10, 2023
Purpose:
Pain
in
knee
osteoarthritis
(KOA)
causes
life
quality
decrease
and
is
the
common
complaint
of
patient
with
KOA.
Cartilage
destruction
KOA
induced
inflammation
process
that
caused
pain.
tissue
injury
around
joint
quadriceps
weakness
due
to
neural
inhibition
on
activation
(Arthrogenic
Muscle
Inhibition
(AMI)).
Combination
blood
flow
restriction
(BFR)
low
intensity
resistance
training
(LIRT)
significantly
showed
improvement
visual
analog
scale
(VAS),
but
prescription
so
variative
limited
Indonesia.Patients
methods:
This
was
clinical
experimental
study
randomized
control
trial
pre-test
post-test
design.
Subjects
were
28
(50-70
years
old).
Intervention
group
(n=14)
received
combination
LIRT
(30%
1-RM;
75
repetitions)
BFR
(50
mmHg).
Control
repetitions).
Both
groups
twice
a
week
q-bench
machine
for
6
weeks.
Visual
assessed
before
after
program.Results:
There
significant
VAS
program
both
(intervention
group,
p=0.000;
p=0.000).
delta
between
(p=0.000)
(p=0.000).
The
effect
size
value
intervention
10.08
(very
large)
3.42
large).Conclusions:
addition
muscle
weeks
can
improve
more
than
alone
osteoarthritis.
Язык: Английский