Myelin: A possible proton capacitor for energy storage during sleep and energy supply during wakefulness

Progress in Biophysics and Molecular Biology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

There are several physiological reasons why biological organisms sleep. One key one concerns brain metabolism. In our article we discuss the role of metabolism in myelin, based on recent discovery that myelin contains mitochondrial components enable production adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). These probably originate from vesiculation membranes form derived vesicles (MDVs). We hypothesize acts as a proton capacitor, accumulating energy protons during sleep and converting it to ATP OXPHOS wakefulness. Empirical evidence supporting hypothesis is discussed, including data metabolic activity, MDVs, allometric scaling between white matter volume duration mammals.

Язык: Английский

"Acidic and Basic Proteins from Spider Latrodectus Pallidus Venom that Induce Formation of Non-Bilayer Phase and Increase Proton Capacity in Model Myelin Membranes Feature High Sequence Homology to Isoforms of Myelin Basic Protein: Pharmacological Relevance"

Biomedical Journal of Scientific & Technical Research, Год журнала: 2024, Номер 56(4)

Опубликована: Май 23, 2024

This study describes the isolation of novel acidic and basic proteins from venom Latrodectus pallidus (white widow spider), which exhibit high amino acid sequence homology to 18.5 kDa isoforms myelin proteins. explores ability model membranes, composed phospholipids spider venom, absorb protons form a non-bilayer lipid phase.

Язык: Английский

Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance

The Journal of Membrane Biology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Язык: Английский