Zinc
nanoparticles
(ZnNPs)
are
a
viable
option
in
number
of
disciplines,
including
cancer
treatment,
due
to
their
special
features.
Among
the
several
techniques
for
synthesizing
ZnNP,
biosynthesis
with
natural
extracts
is
highly
effective
and
environmentally
benign
method,
especially
uses
biomedicine.
Using
an
aqueous
extract
marine
red
seaweed
Jania
rubens,
we
created
unique
biosynthetic
technique
this
study
manufacture
ZnNPs.
The
produced
ZnNPs
have
characteristic
flower-like
form,
as
seen
by
scanning
electron
microscopy
(SEM)
transmission
(TEM).
production
involvement
biomolecules
synthesis
process
were
validated
energy-dispersive
X-ray
spectroscopy
(EDAX)
Fourier
transform
infrared
(FTIR)
techniques.
MTT
assay,
cytotoxic
effects
biosynthesized
evaluated,
indicating
ability
inhibit
MCF-7
breast
cells.
Furthermore,
ZnNPs'
cytotoxicity
against
cells
was
live/dead
imaging
experiments,
which
supported
results.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 18, 2025
Sudden
cardiac
arrest
among
young
people
is
a
recent
worldwide
risk,
and
it
noticed
that
with
arrhythmia
are
more
susceptible
to
various
heart
diseases.
Manual
classification
can
be
error-prone,
certainly,
there
need
for
automation
classify
ECG
signals
predict
accurately.
The
proposed
self-attention
artificial
intelligence
auto-encoder
algorithm
proved
an
effective
strategy
novel
modified
Kalman
filter
pre-processing.
We
achieved
24.00
SNRimp,
0.055
RMSE,
22.1
PRD%
-5db,
20.4
0.0245
12
whereas
14.05
0.010
7.25
PRD%,
which
reduces
the
signal
noise
during
pre-processing
improves
visibility
of
QRS
complex
R-R
peaks
waveform.
extracted
features
were
used
in
network
neurons
execute
MIT-BIH
databases
using
newly
developed
autoencoder
(AE)
algorithm.
results
compared
existing
models,
revealing
system
outperforms
prediction
precision
99.91%,
recall
99.86%,
accuracy
99.71%.
It
confirmed
self-attention-AE
training
promising,
benefits
diagnosis
ECGs
conditions
solve
real-world
problems.
Microarray
technology
has
become
a
vital
tool
in
cardiovascular
research,
enabling
the
simultaneous
analysis
of
thousands
gene
expressions.
This
capability
provides
robust
foundation
for
heart
disease
classification
and
biomarker
discovery.
However,
high
dimensionality,
noise,
sparsity
microarray
data
present
significant
challenges
effective
analysis.
Gene
selection,
which
aims
to
identify
most
relevant
subset
genes,
is
crucial
preprocessing
step
improving
accuracy,
reducing
computational
complexity,
enhancing
biological
interpretability.
Traditional
selection
methods
often
fall
short
capturing
complex,
nonlinear
interactions
among
limiting
their
effectiveness
tasks.
In
this
study,
we
propose
novel
framework
that
leverages
deep
neural
networks
(DNNs)
optimizing
using
data.
DNNs,
known
ability
model
patterns,
are
integrated
with
feature
techniques
address
high-dimensional
The
proposed
method,
DeepGeneNet
(DGN),
combines
DNN-based
into
unified
framework,
ensuring
performance
meaningful
insights
underlying
mechanisms.
Additionally,
incorporates
hyperparameter
optimization
innovative
U-Net
segmentation
further
enhance
accuracy.
These
optimizations
enable
DGN
deliver
scalable
results,
outperforming
traditional
both
predictive
accuracy
Experimental
results
demonstrate
approach
significantly
improves
compared
other
methods.
By
focusing
on
interplay
between
learning,
work
advances
field
genomics,
providing
interpretable
future
applications.
Sensors,
Год журнала:
2025,
Номер
25(7), С. 2323 - 2323
Опубликована: Апрель 6, 2025
Dynamic
behavior
is
prevalent
in
biological
and
condensed
matter
systems
at
the
nano-
mesoscopic
scales.
Typically,
we
capture
images
as
"snapshots"
to
demonstrate
evolution
of
a
system,
coherent
X-ray
diffraction
imaging
(CDI),
lensless
technique,
provides
nanoscale
resolution,
allowing
us
clearly
observe
these
microscopic
phenomena.
This
paper
presents
new
dynamic
CDI
method
based
on
zone-plate
optics
aiming
overcome
limitations
existing
techniques
fast
processes
by
integrating
spatio-temporal
dual
constraint
with
probe
constraint.
In
this
method,
modulus-enforced
temporal
correlation
sample
low-frequency
information
are
exploited
combined
an
empty
static
region
sample.
Using
achieved
resolution
20
Hz
spatial
13.2
nm,
which
were
verified
visualized
experimental
results.
Further
comparisons
showed
that
reconstructed
consistent
ptychography
reconstruction
results,
confirming
accuracy
feasibility
method.
work
expected
provide
tool
for
materials
science
life
sciences,
promoting
deeper
understanding
complex
processes.
Laser & Photonics Review,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 3, 2025
Abstract
Near‐infrared
II
(NIR‐II,
900–1880
nm)
fluorescence
confocal
microscopy
enables
in
vivo
imaging
with
high
spatial
resolution
at
large
depth.
Nonetheless,
three
dimensional
(3D)
requires
capturing
substantial
pixels
and
prolonged
laser
scanning,
leading
to
phototoxicity,
exogenous
probe
metabolic
decay,
loss
of
information
on
dynamic
anatomical
structures.
Strategies
diminish
duration
can
be
considered
by
decreasing
the
actual
pixel
dwell
time
without
deterioration
quality.
In
this
study,
a
novel
approach
combining
NIR‐II
is
introduced
deep
learning
interpolation
network,
which
substantially
decreases
axial
sampling
frequency
requirements,
achieving
equivalent
hundred‐nanosecond
3D
visualization
vivo.
By
applying
cerebral
vessel
(CVI)
network
field‐of‐view
(FOV)
microscopic
imaging,
up
16‐fold
increase
has
been
achieved
scanning
speed,
reducing
from
8
µs
500
ns.
This
significantly
reduces
laser‐induced
damage
biological
samples,
lessens
need
for
extending
metabolism
probes,
facilitates
potential
rapid
biomedical
applications.
Benchmarking
tests
show
CVI
achieves
best
performance
compared
conventional
methods
both
lateral
cross‐sectional
images.