Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Cells, Год журнала: 2023, Номер 12(1), С. 184 - 184

Опубликована: Янв. 2, 2023

Immune cells and commensal microbes in the human intestine constantly communicate with react to each other a stable environment order maintain healthy immune activities. system-microbiota cross-talk relies on complex network of pathways that sustain balance between tolerance immunogenicity. Probiotic bacteria can interact stimulate intestinal microflora modulate specific functions homeostasis. Growing evidence shows probiotic present important health-promoting immunomodulatory properties. Thus, use probiotics might represent promising approach for improving system So far, few studies have been reported beneficial modulatory effect probiotics. However, many others, which are mainly focused their metabolic/nutritional properties, published. Therefore, mechanisms behind interaction host only partially described. The review aims collect summarize most recent scientific results resulting implications how improve functions. Hence, description currently known is provided.

Язык: Английский

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Exopolysaccharides of Lactic Acid Bacteria: Production, Purification and Health Benefits towards Functional Food

Nutrients, Год журнала: 2022, Номер 14(14), С. 2938 - 2938

Опубликована: Июль 18, 2022

Lactic acid bacteria (LAB) are capable of synthesising metabolites known as exopolysaccharides (EPS) during fermentation. Traditionally, EPS plays an important role in fermented dairy products through their gelling and thickening properties, but they can also be beneficial to human health. This bioactivity has gained attention applications for functional foods, which leads them have prebiotic, immunomodulatory, antioxidant, anti-tumour, cholesterol-lowering anti-obesity activity. Understanding the parameters conditions is crucial optimising yields from LAB food industry. review provides overview market together with biosynthesis EPS. Factors influencing production well methods isolation, characterisation quantification reviewed. Finally, health benefits associated discussed.

Язык: Английский

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Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 15: suitability of taxonomic units notified to EFSA until September 2021

EFSA Journal, Год журнала: 2022, Номер 20(1)

Опубликована: Янв. 1, 2022

The qualified presumption of safety (QPS) approach was developed to provide a generic pre-evaluation the biological agents. QPS is based on an assessment published data for each agent, with respect its taxonomic identity, body relevant knowledge and concerns. Safety concerns are, where possible, confirmed at species/strain or product level reflected by 'qualifications'. list updated in relation revised taxonomy genus

Язык: Английский

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Bacillus species in food fermentations: an underappreciated group of organisms for safe use in food fermentations

Current Opinion in Food Science, Год журнала: 2023, Номер 50, С. 101007 - 101007

Опубликована: Фев. 10, 2023

Язык: Английский

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Unlocking the Potential of Probiotics: A Comprehensive Review on Research, Production, and Regulation of Probiotics

Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер 16(5), С. 1687 - 1723

Опубликована: Март 28, 2024

Язык: Английский

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Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 19: Suitability of taxonomic units notified to EFSA until September 2023

EFSA Journal, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 1, 2024

The qualified presumption of safety (QPS) process was developed to provide a assessment approach for microorganisms intended use in food or feed chains. QPS is based on an published data each taxonomic unit (TU), with respect its identity, the body relevant knowledge and concerns. Safety concerns identified TU are, where possible, confirmed at species/strain product level reflected by 'qualifications'. In period covered this Statement, no new information found that would change status previously recommended TUs. Of 71 notified EFSA between April September 2023 (30 as additives, 22 enzymes 7 novel foods 12 from plant protection products [PPP]), 61 were not evaluated because: 26 filamentous fungi, 1

Язык: Английский

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Milk and Its Derivatives as Sources of Components and Microorganisms with Health-Promoting Properties: Probiotics and Bioactive Peptides

Foods, Год журнала: 2024, Номер 13(4), С. 601 - 601

Опубликована: Фев. 16, 2024

Milk is a source of many valuable nutrients, including minerals, vitamins and proteins, with an important role in adult health. dairy products naturally containing or added probiotics have healthy functional food properties. Indeed, probiotic microorganisms, which beneficially affect the host by improving intestinal microbial balance, are recognized to immune response other biological functions. In addition macronutrients micronutrients, biologically active peptides (BPAs) been identified within amino acid sequences native milk proteins; hydrolytic reactions, such as those catalyzed digestive enzymes, result their release. BPAs directly influence numerous pathways evoking behavioral, gastrointestinal, hormonal, immunological, neurological, nutritional responses. The application drug development could improve consumer health provide therapeutic strategies for treatment prevention diseases. Herein, we review scientific literature on probiotics, products, special attention from minor species (buffalo, sheep, camel, yak, donkey, etc.); safety assessment will be also taken into consideration. Finally, recent advances foodomics unveil human discover novel peptide provided.

Язык: Английский

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Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 21: Suitability of taxonomic units notified to EFSA until September 2024

EFSA Journal, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 1, 2025

Abstract The qualified presumption of safety (QPS) process was developed to provide a assessment approach for microorganisms intended use in food or feed chains. In the period covered by this Statement, no new information found that would change status previously recommended QPS taxonomic units (TUs). TUs list were updated based on verification, against their respective authoritative databases, correctness names and completeness synonyms. Of 54 notified EFSA between April September 2024 (33 as additives, 17 enzymes 4 novel foods), 50 not evaluated because: 12 filamentous fungi, 1 Enterococcus faecium 8 Escherichia coli (all excluded from evaluation), 29 already have status. One notification (Ensifer adhaerens) previous Panel Statement. Another (Enterococcus lactis) 3‐year cycle reassessed within document. Two first time assessed possible status: Serratia plymuthica Lacticaseibacillus huelsenbergensis. Bacillus thuringiensis nakamurai been response internal requests. following concluded five TUs. L. huelsenbergensis can be granted its close relatedness several other species. E. lactis is due insufficient safety. S. B. are concerns. cannot lack body knowledge chain.

Язык: Английский

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Considerations for determining safety of probiotics: A USP perspective

Regulatory Toxicology and Pharmacology, Год журнала: 2022, Номер 136, С. 105266 - 105266

Опубликована: Окт. 4, 2022

A history of safe use is a backbone safety assessments for many current probiotic species, however, there no global harmonization regarding requirements establishing in foods and supplements. As manufacturers are increasingly seeking to new strains, novel next-generation probiotics, justification based on significant may be challenged. There efforts underway by variety stakeholders, including the United States Pharmacopeia (USP), develop best practices guidelines assessing quality probiotics. initiative USP seeks provide expert advice specific considerations Toward this goal, review provides helpful summary guide regulatory guidelines. We question suitability traditional animal toxicology studies designed testing chemicals relevance safety. This includes discussion excessive dose levels, length repeated toxicity needed, most suitable species used studies. In addition, importance proper manufacturing with regard final product also included. Thus, an outline essential parameters comprehensive assessment provided.

Язык: Английский

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Antifungal activity of Lactiplantibacillus plantarum isolated from fruit and vegetables and detection of novel antifungal VOCs from fungal-LAB co-cultures

Food Bioscience, Год журнала: 2024, Номер 58, С. 103824 - 103824

Опубликована: Фев. 29, 2024

Undesired microbiota, such as filamentous fungi, negatively impacts the food sector leading to huge losses of produce. For this reason, preservatives are often used reduce microbial contamination. In context, use food-grade antagonistic microorganisms has gained international relevance a promising alternative synthetic additives. Lactic Acid Bacteria (LAB) with antifungal activity might have strain-specific ability control decay agents and their application bio-control tools is growing worldwide. work, eight Lactiplantibacillus plantarum strains were selected against Aspergillus niger, one main fungal contaminants foods, deeply investigated. The overlay method was for an initial fast screening, then presence metabolites evaluated in supernatants (CFSs) by HPLC/DAD volatilome GC–MS analysis. Contribution volatile organic compounds (VOCs) assessed plate-on-plate without physical contact between moulds LAB. order determine inducible VOCs, fungal-LAB co-cultures carried out glass tubes direct GC-MS analyses. Antifungal acetic acid, 2-Nonanone 2-Undecanone produced constitutively all strains. Whereas fourteen VOCs appeared only co-cultures. Six identified co-cultures, three previously mentioned individually tested A. niger airtight contact-less petri dishes assay. Among those, trans-2-Octenal 2-Nonanol had higher niger. These results showed that L. could effectively inhibit growth when vitro. addition, different detected pointing metabolism modulation mediated enhanced activity.

Язык: Английский

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