Arsenic species in coastal marine fish species from the Southwest Atlantic Ocean: Human health risk implications

Marine Pollution Bulletin, Год журнала: 2025, Номер 216, С. 117971 - 117971

Опубликована: Апрель 17, 2025

Язык: Английский

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Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during should be studied. applications ensure commercial availability of normal karyotype human primary toxicity assessment hMSCs could serve as alternatives immortalized cell models. In this work, we evaluated the potential testing using inorganic arsenic (iAs) a case study. were exposed iAs at different durations track cellular aging study stability. exposures (48 h) resulted micronuclei induction. also 6 days determine if would become more susceptible chromosomal damage following exposure model genotoxicant, mitomycin C (MMC). The culture duration did not alter MMC potency, indicating that susceptibility remained unchanged. We used gene expression analysis investigate molecular impacts on over course short (3 total) long (30 experiments. Both activated biomarkers associated with oxidative stress, but direct DNA damage, providing support an indirect mode action genotoxicity. Overall, establishes utility new screening provides mechanistic information underlying toxicity.

Язык: Английский

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Risks of exceeding health-based guidance values for toxic metals and metalloids through seaweed and halophyte consumption

Food Control, Год журнала: 2025, Номер unknown, С. 111385 - 111385

Опубликована: Апрель 1, 2025

Язык: Английский

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Safe consumption of marine invaders: a snapshot of Diadema setosum contamination levels in the frame of European novel food standards

Food Additives & Contaminants Part A, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Апрель 30, 2025

Consuming marine invaders is increasingly recognized as an effective strategy for controlling their populations. Following European legislation (Regulation (EU) 2015/2283 on novel foods), it crucial to ensure that these invasive species are safe consumption. This study presents the first screening of potential contaminants in gonad samples Diadema setosum, sea urchin species, offering a snapshot contamination levels. The analyzed Perfluoroalkyl substances (PFASs), Polychlorinated biphenyls (PCBs), Marine biotoxins (MBs), and broad spectrum inorganic elements, including heavy metals. results showed all were significantly below maximum limits set regulated fishery products Europe, though some concerns arose from levels cadmium (Cd) perfluorooctanoic acid (PFOA) detected certain specimens. These preliminary findings underscore need more extensive investigations into D. setosum contaminant safety

Язык: Английский

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Cancer Burden from Dietary Exposure to Inorganic Arsenic in the United States: Risk Assessment and Policy Implications

Journal of Food Protection, Год журнала: 2025, Номер unknown, С. 100520 - 100520

Опубликована: Май 1, 2025

Язык: Английский

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