Effects of Polyvinyl Chloride (PVC) Microplastic Particles on Gut Microbiota Composition and Health Status in Rabbit Livestock DOI Open Access

Péter Papp,

Orsolya Ivett Hoffmann, Balázs Libisch

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12646 - 12646

Опубликована: Ноя. 25, 2024

The widespread use of polyvinyl chloride (PVC) and its entry into humans livestock is serious concern. In our study, we investigated the impact PVC treatments on physiological, pathological, hormonal, microbiota changes in female rabbits. Trend-like alterations weight were observed spleen, liver, kidney both low (P1) high dose (P2) treatment groups. Histopathological examination revealed exfoliation intestinal mucosa treated groups compared to control, microplastic particles penetrated embedded spleen. Furthermore, P1 P2 showed increased 17-beta-estradiol (E2) hormone levels, indicating early sexual maturation. Moreover, elevated tumor necrosis factor alpha (TNF-α) levels suggest inflammatory reactions associated with treatment. Genus-level analyses gut group several genera or decreased abundance. conclusion, significant trend-like correlations demonstrated between content feed parameters. To knowledge, this first study investigate broad-spectrum effects exposure These results highlight potential health risks exposure, warranting further investigations animals humans.

Язык: Английский

Effects of Polyvinyl Chloride (PVC) Microplastic Particles on Gut Microbiota Composition and Health Status in Rabbit Livestock DOI Open Access

Péter Papp,

Orsolya Ivett Hoffmann, Balázs Libisch

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12646 - 12646

Опубликована: Ноя. 25, 2024

The widespread use of polyvinyl chloride (PVC) and its entry into humans livestock is serious concern. In our study, we investigated the impact PVC treatments on physiological, pathological, hormonal, microbiota changes in female rabbits. Trend-like alterations weight were observed spleen, liver, kidney both low (P1) high dose (P2) treatment groups. Histopathological examination revealed exfoliation intestinal mucosa treated groups compared to control, microplastic particles penetrated embedded spleen. Furthermore, P1 P2 showed increased 17-beta-estradiol (E2) hormone levels, indicating early sexual maturation. Moreover, elevated tumor necrosis factor alpha (TNF-α) levels suggest inflammatory reactions associated with treatment. Genus-level analyses gut group several genera or decreased abundance. conclusion, significant trend-like correlations demonstrated between content feed parameters. To knowledge, this first study investigate broad-spectrum effects exposure These results highlight potential health risks exposure, warranting further investigations animals humans.

Язык: Английский

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