Parkinson’s Spectrum Mechanisms in Pregnancy: Exploring Hypothetical Scenarios for MSA in the Era of ART
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3348 - 3348
Опубликована: Апрель 3, 2025
Multiple
System
Atrophy
(MSA)
is
a
rare,
rapidly
progressive
neurodegenerative
disorder
marked
by
autonomic
dysfunction,
parkinsonism,
and
cerebellar
ataxia.
While
predominantly
affecting
individuals
in
their
fifth
or
sixth
decade,
advancements
assisted
reproductive
technologies
(ART)
have
created
new
clinical
scenarios
involving
pregnancies
women
within
MSA's
typical
onset
range.
Given
the
scarcity
of
documented
MSA
pregnancies,
this
review
leverages
insights
from
related
Parkinson's
spectrum
mechanisms
to
explore
hypothetical
for
how
pregnancy-induced
physiological
changes
might
influence
progression.
Pregnancy-induced
hormonal
fluctuations,
including
elevated
estrogen
progesterone
levels,
may
modulate
α-synuclein
aggregation
neuroinflammatory
pathways.
Immune
adaptations,
such
as
fetal
microchimerism
Th2-biased
immune
profiles,
introduce
additional
complexities,
particularly
donor
embryo
complex
microchimerism.
Metabolic
demands
oxidative
stress
further
intersect
with
these
mechanisms,
potentially
accelerating
disease
We
analyze
existing
literature
theoretical
models,
emphasizing
need
interdisciplinary
research.
Clinical
implications
are
discussed
propose
evidence-based
strategies
optimizing
maternal-fetal
outcomes.
This
paper
identifies
critical
knowledge
gaps
proposes
avenues
future
investigation
optimize
outcomes
unique
underexplored
intersection.
Язык: Английский
Potential Roles of Natural Antioxidants in Modulating Neurodegenerative Disease Pathways
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Harnessing Antioxidants for Enhanced Pregnancy Success and Fetal Development
Open Access Journal of Gynecology,
Год журнала:
2024,
Номер
9(1)
Опубликована: Янв. 1, 2024
Pregnancy
is
a
dynamic
physiological
state
marked
by
increased
oxidative
stress,
presenting
challenges
to
maternal
health
and
fetal
development.
This
review
explores
the
intricate
relationship
between
stress
pregnancy
outcomes,
emphasizing
potential
of
antioxidants
as
crucial
mediators
in
maintaining
healthy
balance.
The
role
mitigating
cellular
damage,
inflammation,
adverse
outcomes
discussed,
with
focus
on
their
impact
reproductive
success
long-term
Key
antioxidants,
including
vitamins
C
E,
selenium,
coenzyme
Q10,
polyphenols,
are
explored
context
mechanisms
action
clinical
applications.
delves
into
implications
antioxidant
supplementation
fertility,
implantation,
early
embryonic
development,
providing
insights
optimizing
success.
applications
explored,
encompassing
patient-specific
factors
interpreting
study
results.
Язык: Английский