Clinical and functional eye condition changes in the dry form of age macular degeneration depending on the AREDS stage
Russian Ophthalmological Journal,
Год журнала:
2024,
Номер
17(1), С. 62 - 67
Опубликована: Март 25, 2024
Purpose:
to
assess
the
functional
state
of
eyes
in
age-related
macular
degeneration
depending
on
AREDS
classification
stage.
Material
and
methods.
A
clinical
study
60
patients
(120
eyes)
with
dry
AMD
form,
aged
55.1
±
4.2
years,
involved
30
(60
52.7
3.9
years
2
category
(initial
stage,
group1)
57.9
7.8
3
(intermediate
group
2).
The
complex
research
visual
acuity
measurement,
including
assessment
near
vision
various
illumination
conditions
according
authors’
methodology,
fluorescein
angiography,
refractometry,
tonometry,
optical
coherence
tomography
(OCT),
ultrasound
duplex
scanning
eye;
an
immunological
aimed
at
determining
interleukins
interferons
blood
serum.
Results.
Visual
was
found
depend
test
healthy
subjects
substantially
drop
all
levels
AMD,
especially
3rd
With
development
activity
immune
response
recorded.
groups
1
showed
increase
inflammatory
a
depression
anti-inflammatory
response.
In
1,
recorded
IL-I
by
23.5%
(p
<
0.05),
IL5
25.4%
IL8
19.9%
0.05).
2,
value
these
parameters
exceeded
norm
32.1,
39.5
respectively.
immunity
(IL10
TGF
l)
were
lower
than
reference
level
18.3
24.6%
0.05)
24.3
30.75
2.
It
established
that
degree
imbalance
system
is
associated
stage
AREDS.
3,
content
pro-inflammatory
those
1:
12.5%
11.9%
11,
2%
IL10
l
10.2
11.8%
Conclusion.
Near
measurement
may
be
used
as
sensitive
diagnostic
patients.
At
early
development,
disorder
defense
observed,
taking
form
activation
spectrum
component,
well
microcirculatory
changes
Homeostatic
eye
appear
disease
are
progressing
picture
deteriorating.
greatest
Язык: Английский
APPLICATION OF THE FUNCTIONAL-TOPICAL DIAGNOSTIC METHOD TO IDENTIFY THE PATHOLOGICAL PROCESS IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION
Успехи геронтологии,
Год журнала:
2024,
Номер
37(4), С. 436 - 441
Опубликована: Окт. 1, 2024
Язык: Русский
Role of DNA damage and repair in chronic eye diseases
Clinical Medicine (Russian Journal),
Год журнала:
2023,
Номер
101(9-10), С. 474 - 482
Опубликована: Ноя. 13, 2023
Vision
is
essential
for
everyday
activities,
yet
the
most
common
eye
diseases
—
cataracts,
diabetic
retinopathy
(DR),
age-related
macular
degeneration
(AMD),
and
glaucoma
lead
to
vision
loss
with
age.
Cataract
surgery
one
of
frequently
performed
operations
results
are
usually
excellent
in
absence
accompanying
pathology.
However,
patients
DR,
AMD,
often
develop
significant
visual
impairments.
The
pathogenesis
these
multifactorial
involves
genetic
hereditary
components,
recent
data
confirming
role
DNA
damage
repair
as
important
pathogenic
factors.
In
this
review,
we
describe
detail
main
mechanisms
repair,
including
base
excision
nucleotide
double-strand
break
discuss
their
development
glaucoma.
Язык: Английский