Oxidative Biomarkers Associated with the Pulmonary Manifestation of Post-COVID-19 Complications

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(13), С. 4253 - 4253

Опубликована: Июнь 25, 2023

The role of mitochondria in post coronavirus disease 2019 (post-COVID-19) complications is unclear, especially the long-term pulmonary complications. This study aims to investigate association between post-COVID-19 and mitochondrial regulatory proteins context oxidative stress.Patients who had recovered from COVID-19 were enrolled. According evidence persistent interstitial lung lesions on computed tomography (CT), patients divided into a group (P(+)) control without (P(-)). We randomly selected 80 for investigation (40 subjects each group). Biomarkers levels determined by enzyme-linked immunosorbent assay (ELISA).The serum concentrations significantly higher P(+) group, including PTEN-induced kinase 1 (PINK1): 1.62 [1.02-2.29] ng/mL vs. 1.34 [0.94-1.74] (p = 0.046); Dynamin-1-like protein (DNM1L): 1.6 [0.9-2.4] IQR 0.9 [0.5-1.6] 0.004); Mitofusin-2 (MFN2): 0.3 [0.2-0.5] 0.2 [0.1-0.3] 0.001). Patients also chemokine ligand 18 (PARC, CCL18), IL-6, tumour necrosis factor-alpha (TNF-α) cytokines than P(-) group. concentration interferon alpha (IFN-α) was decreased Furthermore, we observed statistically significant correlations advanced glycation end product (sRAGE) TNF-α (Pearson's factor R 0.637; p < 0.001) DNM1L IFN-α 0.501; 0.002) patients.Elevated biomarkers with indicate their possible pathobiology sequelae. Oxidative stress associated immune response inflammation after COVID-19. could be promising biomarker predicting may potential target therapeutic intervention

Язык: Английский

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Clinical characterization and factors associated with quality of life in Long COVID patients: Secondary data analysis from a randomized clinical trial

PLoS ONE, Год журнала: 2023, Номер 18(5), С. e0278728 - e0278728

Опубликована: Май 16, 2023

Background Long COVID patients suffer a negative impact on their quality of life, as well functioning, productivity or socialization. There is need to better understand the individual experience and circumstances surrounding these patients. Objective To characterize clinical picture identify factors associated with life. Methods A secondary data analysis from randomized trial (RCT) was carried out 100 treated by Primary Health Care residents in territory Aragon (northeast Spain). The main variable study evaluated using SF-36 Questionnaire, relation socio-demographic variables. In addition, ten validated scales were used that contemplated cognitive, affective, functional social status, personal constructs. Correlation statistics linear regression model calculated. Results decrease levels physical mental health. On one hand, higher number persistent symptoms (b = -0.900, p 0.008), worse functioning 1.587, 0.002) sleep -0.538, 0.035) are predictors subscale. other educational level 13.167, 0.017), lower -0.621, 0.057) affective affectation -1.402, p<0.001) Conclusion It necessary design rehabilitation programs consider both health patients, thus obtaining an improvement

Язык: Английский

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T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 3, 2024

As about 10% of patients with COVID-19 present sequelae, it is important to better understand the physiopathology so-called long COVID.

Язык: Английский

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Extreme obesity is a strong predictor for in-hospital mortality and the prevalence of long-COVID in severe COVID-19 patients with acute respiratory distress syndrome

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Ноя. 1, 2022

Abstract Acute Respiratory Distress Syndrome (ARDS) is common in COVID-19 patients and associated with high mortality. The aim of this observational study was to describe patients’ characteristics outcome, identifying potential risk factors for in-hospital mortality developing Long-COVID symptoms. This retrospective included all ARDS (cARDS) the period from March 2020 2021 who were invasively ventilated at intensive care unit (ICU) University Hospital Dresden, Germany. Between October December discharged alive (at minimum 6 months after hospital discharge—midterm survival) contacted interviewed about persistent symptoms possibly as well quality their lives using EQ-5D-5L-questionnaire. defined occurrence one least discharge. Risk assessed Cox regression models by relative (RR) regression. 184 Patients (male: n = 134 (73%), median age 67 (range 25–92). All diagnosed according Berlin Definition. 89% (n 164) had severe (Horovitz-index < 100 mmHg). In 27% 49) extracorporeal membrane oxygenation necessary maintain gas exchange. length stay 19 days 1–60). ICU 51%, 59%. Midterm survival (median 11 months) 83% 55) 78% 43) these presented fatigue most symptom (70%). Extreme obesity (BMI > 40 kg/m 2 ) strongest predictor (hazard ratio: 3.147, confidence interval 1.000–9.897) (RR 1.61, 1.26–2.06). In-hospital cARDS high, but 80% survived midterm observation period. Nonetheless, developed BMI identified independent factor Trial registration DRKS-ID DRKS00027856.

Язык: Английский

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Cardiac Manifestations of Post-Acute COVID-19 Infection

Current Cardiology Reports, Год журнала: 2022, Номер 24(12), С. 1775 - 1783

Опубликована: Ноя. 2, 2022

Язык: Английский

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