ЕФЕКТИВНІСТЬ ІНГІБІТОРІВ НАТРІЙЗАЛЕЖНОГО КОТРАНСПОРТЕРУ ГЛЮКОЗИ 2 ТИПУ В КОРЕКЦІЇ ІНСУЛІНОРЕЗИСТЕНТНОСТІ У ЖІНОК РЕПРОДУКТИВНОГО ВІКУ ІЗ ЦУКРОВИМ ДІАБЕТОМ 2 ТИПУ
Art of Medicine,
Год журнала:
2025,
Номер
unknown, С. 46 - 52
Опубликована: Апрель 2, 2025
As
a
result
of
insulin
resistance
(IR),
women
reproductive
age
have
higher
risk
the
development
and
progressing
type
2
diabetes
(T2DM),
which
contributes
to
decrease
in
fertility
potential.
Despite
ongoing
scientific
discoveries
fields
endocrinology
patient-centered
treatment
goals,
significant
part
global
population
lacks
compensation
for
T2DM.
Therefore,
one
alternative
approaches
treating
with
T2DM
should
be
considered
achieving
glycemic
targets
while
simultaneously
correcting
IR.
The
aim
is
evaluate
efficacy
sodium-glucose
cotransporter
inhibitors
(SGLT2i)
correction
carbohydrate
lipid
metabolism
A
12-week
study
involved
30
who
met
criteria.
Based
on
their
hypoglycemic
therapy,
participants
were
divided
into
two
groups:
group
(n=15),
received
standard
medication
therapy
(SMT)
combined
SGLT2i
(dapagliflozin
10
mg/daily
doses
or
empagliflozin
10-25
doses),
control
SMT
consisting
metformin
2000
doses,
alpha-lipoic
acid
600
inositol
doses.
groups
comparable
regarding
primary
disease
its
duration,
age,
body
composition,
anthropometric
parameters,
laboratory-instrumental
characteristics
IR,
characteristics.
Analysis
after
12
weeks
revealed
differences
outcomes
between
groups.
Women
group,
іSGLT2
as
regimen,
experienced
statistically
reduction
IR
markers.
Specifically,
HOMA-IR
index
decreased
2.3-fold
compared
baseline
values
(study
vs.
group:
∆+127.77%;
p<0.001).
Improvements
also
observed
composition:
1.4-fold
visceral
fat
content
(VFC)
1.3-fold
total
percentage
∆+38.25%;
p=0.002
∆+33.23%;
p=0.003,
respectively).
Patients
achieved
better
average
level
glycated
hemoglobin
(HbA1C)
7.26±0.86%
(p<0.001)
8.48±0.80%
representing
an
improvement
∆+16.80%
(p=0.003).
Additionally,
metabolic
age—a
crucial
indicator
overall
health—improved
significantly
group.
It
by
4.25%,
resulting
mean
48.20±4.33
years
(p<0.001),
55.07±4.59
findings
this
highlight
potential
combining
This
therapeutic
approach
not
only
achieves
but
facilitates
comprehensive
symptoms,
normalizes
metabolism,
improves
parameters.
With
favorable
safety
profile
demonstrated
efficacy,
integration
management
protocols
offers
promising
optimizing
specific
patient
population.
These
results
underscore
importance
personalized
strategies
aimed
at
addressing
both
health
Язык: Английский
MATHEMATICAL MODEL AS A METHOD OF EVALUATING THE ACTIVATION OF ONCOGENESIS IN PATIENTS WITH TYPE 2 DIABETES
Clinical and Preventive Medicine,
Год журнала:
2025,
Номер
2, С. 68 - 73
Опубликована: Апрель 17, 2025
Introduction.
Numerous
studies
have
proven
the
link
between
diabetes
and
cancer.
Chronic
metabolic
disorders
in
type
2
(T2D)
cause
dysregulation
of
intracellular
systems
involved
control
cell
survival,
apoptosis,
proliferation.
The
search
for
markers
activation
carcinogenesis
continues.
Aim.
To
develop
a
method
assessing
oncogenesis
processes
patients
with
T2D
by
creating
mathematical
model
that
takes
into
account
complex
impact
activity
components
insulin
signaling
PI3K/Akt/mTOR.
Materials
methods.
study
28
T2D,
group
consisted
16
practically
healthy
individuals.
examination
included
determining
indicators
reflect
carbohydrate
metabolism
compensation
(glycemia,
glycated
hemoglobin
(HbA1c)),
levels
growth
factors
(insulin,
IGF-1),
activity,
such
as
phospho-PRAS40
phospho-p70S6K.
Statistical
analysis
results
was
performed
using
STATISTIKA-12
software
(StatSoft
Inc.,
USA)
statistical
functions
package
Microsoft
Excel.
Using
obtained
data,
developed
discriminant
analysis.
Results.
In
significantly
elevated
fasting
blood
glucose,
HbA1c,
insulin,
IGF-1,
HOMA-IR
were
observed.
Significantly
increased
phospho-p70S6K
detected
peripheral
mononuclear
cells.
A
has
been
created,
which
allows
to
be
classified
two
groups:
Group
1
–
hyperactivation
signaling,
or
without
hyperactivation.
most
significant
are
levels,
index,
HbA1c.
Conclusions.
Discriminant
proves
importance
comprehensive
approach
assessment
taking
compensation,
sensitivity,
cascade.
confirms
statistically
influence
hyperglycemia,
hyperinsulinemia,
resistance
activating
pathway.
Язык: Английский