Sclerotic prostate cancer bone metastasis: woven bone lesions with a twist DOI Creative Commons
Felipe Eltit, Qiong Wang,

Naomi Jung

и другие.

JBMR Plus, Год журнала: 2024, Номер 8(10)

Опубликована: Июль 20, 2024

Bone metastases are the most severe and prevalent consequences of prostate cancer (PC), affecting more than 80% patients with advanced PC. PCBMs generate pain, pathological fractures, paralysis. As modern therapies increase survival, suffering from these catastrophic consequences. Radiographically, predominantly osteosclerotic, but mechanisms abnormal bone formation how this in density is related to fractures unclear. In study, we conducted a comprehensive analysis on cohort 76 cadaveric PCBM specimens 12 cancer-free as controls. We used micro-computed tomography determine 3D organization quantify characteristics, quantitative backscattering electron microscopy characterize mineral content details structure, nanoindentation mechanical properties, histological immunohistochemical structure composition. define 4 phenotypes: osteolytic, mixed lytic-sclerotic, 2 subgroups osteosclerotic lesions-those residual trabeculae, others without trabeculae. The lesions characterized by presence accumulated trabeculae surfaces within intertrabecular spaces. This higher lacunae density, morphology, irregular orientation. However, content, hardness, elastic modulus at micron-scale were indistinguishable between collagen matrix presents prominent III These characteristics suggest that initiate new deposition woven bone; however, lack subsequent remodeling, absence lamellar its surface, distinguish pathologic conventional bone. Although mineralized retains normal hardness stiffness fibril anisotropy compromised trabecular which may have clinical implications.

Язык: Английский

New players in the landscape of renal cell carcinoma bone metastasis and therapeutic opportunities DOI Creative Commons

Beatrice Cesana,

Claude Cochet, Odile Filhol

и другие.

International Journal of Cancer, Год журнала: 2024, Номер unknown

Опубликована: Сен. 22, 2024

Abstract Approximately one‐third of advanced renal cell carcinoma (RCC) patients develop osteolytic bone metastases, leading to skeletal complications. In this review, we first provide a comprehensive perspective seminal studies on metastasis RCC describing the main molecular modulators and growth factor signaling pathways most important for RCC‐stimulated osteoclast‐mediated destruction. We next focus newer developments revealing with in‐depth details, bidirectional interplay between cancer cells immune stromal microenvironment that can through epigenetic reprogramming, profoundly affect behaviors transformed cells. Understanding their mechanistic interactions is paramount importance advancing both fundamental translational research. These new investigations into landscape RCC‐bone offer novel insights identify potential avenues future therapeutic interventions.

Язык: Английский

Процитировано

1
Sclerotic prostate cancer bone metastasis: woven bone lesions with a twist DOI Creative Commons
Felipe Eltit, Qiong Wang,

Naomi Jung

и другие.

JBMR Plus, Год журнала: 2024, Номер 8(10)

Опубликована: Июль 20, 2024

Bone metastases are the most severe and prevalent consequences of prostate cancer (PC), affecting more than 80% patients with advanced PC. PCBMs generate pain, pathological fractures, paralysis. As modern therapies increase survival, suffering from these catastrophic consequences. Radiographically, predominantly osteosclerotic, but mechanisms abnormal bone formation how this in density is related to fractures unclear. In study, we conducted a comprehensive analysis on cohort 76 cadaveric PCBM specimens 12 cancer-free as controls. We used micro-computed tomography determine 3D organization quantify characteristics, quantitative backscattering electron microscopy characterize mineral content details structure, nanoindentation mechanical properties, histological immunohistochemical structure composition. define 4 phenotypes: osteolytic, mixed lytic-sclerotic, 2 subgroups osteosclerotic lesions-those residual trabeculae, others without trabeculae. The lesions characterized by presence accumulated trabeculae surfaces within intertrabecular spaces. This higher lacunae density, morphology, irregular orientation. However, content, hardness, elastic modulus at micron-scale were indistinguishable between collagen matrix presents prominent III These characteristics suggest that initiate new deposition woven bone; however, lack subsequent remodeling, absence lamellar its surface, distinguish pathologic conventional bone. Although mineralized retains normal hardness stiffness fibril anisotropy compromised trabecular which may have clinical implications.

Язык: Английский

Процитировано

0