IMMUNOSENESCENCE IN SKELETAL MUSCLE: THE ROLE-PLAY IN CANCER CACHEXIA CHESSBOARD DOI Creative Commons
Matteo Giovarelli, Emanuele Mocciaro, Carla Carnovale

и другие.

Seminars in Cancer Biology, Год журнала: 2025, Номер 111, С. 48 - 59

Опубликована: Фев. 26, 2025

With the increase in life expectancy, age-related conditions and diseases have become a widespread relevant social burden. Among these, immunosenescence cancer cachexia play significant often intertwined role. Immunosenescence is progressive aging decline of both innate adaptive immune systems leading to increased infection susceptibility, poor vaccination efficacy, autoimmune disease, malignancies. Cancer affects elderly patients with causing severe weight loss, muscle wasting, inflammation, reduced response therapies. Whereas connections between been raising attention, molecular mechanisms still need be completely elucidated. This review aims at providing current knowledge about interplay immunosenescence, skeletal muscle, cachexia, analyzing pathways known so far involved. Finally, we highlight potential therapeutic strategies suited for population aimed block preserve mass also presenting analysis state-of-the-art related clinical trials.

Язык: Английский

IMMUNOSENESCENCE IN SKELETAL MUSCLE: THE ROLE-PLAY IN CANCER CACHEXIA CHESSBOARD DOI Creative Commons
Matteo Giovarelli, Emanuele Mocciaro, Carla Carnovale

и другие.

Seminars in Cancer Biology, Год журнала: 2025, Номер 111, С. 48 - 59

Опубликована: Фев. 26, 2025

With the increase in life expectancy, age-related conditions and diseases have become a widespread relevant social burden. Among these, immunosenescence cancer cachexia play significant often intertwined role. Immunosenescence is progressive aging decline of both innate adaptive immune systems leading to increased infection susceptibility, poor vaccination efficacy, autoimmune disease, malignancies. Cancer affects elderly patients with causing severe weight loss, muscle wasting, inflammation, reduced response therapies. Whereas connections between been raising attention, molecular mechanisms still need be completely elucidated. This review aims at providing current knowledge about interplay immunosenescence, skeletal muscle, cachexia, analyzing pathways known so far involved. Finally, we highlight potential therapeutic strategies suited for population aimed block preserve mass also presenting analysis state-of-the-art related clinical trials.

Язык: Английский

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