Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population DOI Creative Commons
Qianxing Zhou,

Yamei Wu,

Mingkang Li

и другие.

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 30, 2025

Atherosclerotic dyslipidemia is associated with an increased risk of type 2 diabetes (T2D). Although previous studies have demonstrated association between the atherogenic index plasma (AIP) and insulin resistance, there remains a scarcity large cohort investigating AIP long-term T2D in general population. This study aims to investigate potential individuals normal fasting glucose levels. retrospective included 15,453 participants. The was calculated using formula log [triglyceride (mmol/L)/high-density lipoprotein cholesterol (mmol/L)]. Cox proportional hazard regression models were employed assess risk. nonlinear examined restricted cubic spline (RCS) model. During average follow-up period 6.05 years, 373 participants developed T2D. After adjusting for confounding factors, elevated independently developing (HR 1.763, 95%CI 1.210–2.568, P = 0.003). RCS analysis revealed J-shaped risk, sharp increase when levels exceeded − 0.268. Moreover, time-dependent receiver operating characteristic consistently moderate predictability new-onset within 1 12 years. exhibits Therefore, maintaining below certain threshold (-0.268) might help prevent onset

Язык: Английский

Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population DOI Creative Commons
Qianxing Zhou,

Yamei Wu,

Mingkang Li

и другие.

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 30, 2025

Atherosclerotic dyslipidemia is associated with an increased risk of type 2 diabetes (T2D). Although previous studies have demonstrated association between the atherogenic index plasma (AIP) and insulin resistance, there remains a scarcity large cohort investigating AIP long-term T2D in general population. This study aims to investigate potential individuals normal fasting glucose levels. retrospective included 15,453 participants. The was calculated using formula log [triglyceride (mmol/L)/high-density lipoprotein cholesterol (mmol/L)]. Cox proportional hazard regression models were employed assess risk. nonlinear examined restricted cubic spline (RCS) model. During average follow-up period 6.05 years, 373 participants developed T2D. After adjusting for confounding factors, elevated independently developing (HR 1.763, 95%CI 1.210–2.568, P = 0.003). RCS analysis revealed J-shaped risk, sharp increase when levels exceeded − 0.268. Moreover, time-dependent receiver operating characteristic consistently moderate predictability new-onset within 1 12 years. exhibits Therefore, maintaining below certain threshold (-0.268) might help prevent onset

Язык: Английский

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