Integrating and fragmenting memories under stress and alcohol
Neurobiology of Stress,
Год журнала:
2024,
Номер
30, С. 100615 - 100615
Опубликована: Фев. 8, 2024
Stress
can
powerfully
influence
the
way
we
form
memories,
particularly
extent
to
which
they
are
integrated
or
situated
within
an
underlying
spatiotemporal
and
broader
knowledge
architecture.
These
different
representations
in
turn
have
significant
consequences
for
use
these
memories
guide
later
behavior.
Puzzlingly,
although
stress
has
historically
been
argued
promote
fragmentation,
leading
disjoint
memory
representations,
more
recent
work
suggests
that
also
facilitate
binding
integration.
Understanding
circumstances
under
fosters
integration
will
be
key
resolving
this
discrepancy
unpacking
mechanisms
by
shape
Here,
examine
at
multiple
levels:
linking
together
content
of
individual
experience,
threading
associations
between
related
but
distinct
events,
experience
into
a
pre-existing
schema
sense
causal
structure.
We
discuss
neural
cognitive
each
as
well
findings
regarding
how
stress,
aversive
learning,
negative
affect
modulate
each.
In
analysis,
uncover
indeed
level
show
may
apply
understanding
effects
alcohol,
highlighting
extant
clinical
preclinical
opportunities
further
investigation.
Finally,
consider
implications
fragmentation
memory-guided
behavior,
importance
type
representation
is
potentiated
order
design
appropriate
interventions.
Язык: Английский
Integration of sensory and fear memories in the rat medial temporal lobe: advancing research by Wong et al. (2019)
Опубликована: Фев. 14, 2025
Wong
et
al.
(2019)
used
a
sensory
preconditioning
protocol
to
examine
how
and
fear
memories
are
integrated
in
the
rat
medial
temporal
lobe.
In
this
protocol,
rats
integrate
sound-light
(sensory)
memory
that
forms
stage
1
with
light-shock
(fear)
2
generate
responses
(freezing)
across
test
presentations
of
sound
3.
Here,
we
advance
research
by
showing
that:
1)
how/when
(online
or
at
3)
changes
number
pairings
1;
2)
regardless
it
occurs,
integration
requires
communication
between
two
regions
lobe:
perirhinal
cortex
basolateral
amygdala
complex.
Thus,
“event
familiarity”
determines
but
not
circuitry
which
occurs:
remains
same.
Язык: Английский
Integration of sensory and fear memories in the rat medial temporal lobe
eLife,
Год журнала:
2025,
Номер
13
Опубликована: Март 19, 2025
Wong
et
al.,
2019
used
a
sensory
preconditioning
protocol
to
examine
how
and
fear
memories
are
integrated
in
the
rat
medial
temporal
lobe.
In
this
protocol,
rats
integrate
sound-light
(sensory)
memory
that
forms
stage
1
with
light-shock
(fear)
2
generate
responses
(freezing)
across
test
presentations
of
sound
3.
Here,
we
advance
research
by
showing
(1)
how/when
(online
or
at
3)
changes
number
pairings
1;
(2)
regardless
it
occurs,
integration
requires
communication
between
two
regions
lobe:
perirhinal
cortex
basolateral
amygdala
complex.
Thus,
‘event
familiarity’
determines
but
not
circuitry
which
occurs:
remains
same.
Язык: Английский
Integration of sensory and fear memories in the rat medial temporal lobe: advancing research by Wong et al. (2019)
eLife,
Год журнала:
2024,
Номер
13
Опубликована: Сен. 16, 2024
Wong
et
al.,
2019
used
a
sensory
preconditioning
protocol
to
examine
how
and
fear
memories
are
integrated
in
the
rat
medial
temporal
lobe.
In
this
protocol,
rats
integrate
sound-light
(sensory)
memory
that
forms
stage
1
with
light-shock
(fear)
2
generate
responses
(freezing)
across
test
presentations
of
sound
3.
Here,
we
advance
research
by
showing
(1)
how/when
(online
or
at
3)
changes
number
pairings
1;
(2)
regardless
it
occurs,
integration
requires
communication
between
two
regions
lobe:
perirhinal
cortex
basolateral
amygdala
complex.
Thus,
‘event
familiarity’
determines
but
not
circuitry
which
occurs:
remains
same.
Язык: Английский
Integration of sensory and fear memories in the rat medial temporal lobe: advancing research by Wong et al. (2019)
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 3, 2024
ABSTRACT
Wong
et
al.
(2019)
used
a
sensory
preconditioning
protocol
to
examine
how
and
fear
memories
are
integrated
in
the
rat
medial
temporal
lobe.
In
this
protocol,
rats
integrate
sound-light
(sensory)
memory
that
forms
stage
1
with
light-shock
(fear)
2
generate
responses
(freezing)
across
test
presentations
of
sound
3.
Here,
we
advance
research
by
showing
that:
1)
how/when
(online
or
at
3)
changes
number
pairings
1;
2)
regardless
it
occurs,
integration
requires
communication
between
two
regions
lobe:
perirhinal
cortex
basolateral
amygdala
complex.
Thus,
“event
familiarity”
determines
but
not
circuitry
which
occurs:
remains
same.
Язык: Английский
Integration of sensory and fear memories in the rat medial temporal lobe: advancing research by Wong et al. (2019)
Опубликована: Сен. 16, 2024
Wong
et
al.
(2019)
used
a
sensory
preconditioning
protocol
to
examine
how
and
fear
memories
are
integrated
in
the
rat
medial
temporal
lobe.
In
this
protocol,
rats
integrate
sound-light
(sensory)
memory
that
forms
stage
1
with
light-shock
(fear)
2
generate
responses
(freezing)
across
test
presentations
of
sound
3.
Here,
we
advance
research
by
showing
that:
1)
how/when
(online
or
at
3)
changes
number
pairings
1;
2)
regardless
it
occurs,
integration
requires
communication
between
two
regions
lobe:
perirhinal
cortex
basolateral
amygdala
complex.
Thus,
“event
familiarity”
determines
but
not
circuitry
which
occurs:
remains
same.
Язык: Английский