An ability to respond begins with inner alignment: How phase synchronisation effects transitions to higher levels of agency DOI Creative Commons
Tazzio Tissot,

Mike Levin,

Chris Buckley

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 21, 2024

Abstract How do multiple active components at one level of organisation create agential wholes higher levels organisation? For example, in organismic development, how does the multi-scale autonomy organism arise from interactions molecules, cells and tissues that an contains? And, major evolutionary transitions, a multicellular organism, for as unit selective interests its unicellular ancestors? We utilise computational models way to think about this general question. take deliberately minimalistic notion agent: competency two possible actions minimise stress. Helping ourselves behaviour microscale, we focus on conditions where same type agency appears spontaneously organisation. find simple process positive feedback timing individual responses, loosely analogous natural phase synchronisation weakly coupled oscillators, causes such transition behaviour. The emergent collectives become, quite suddenly, able respond their external stresses (minimal) sense original microscale units. This effects dramatic rescaling system behaviour, quantifiable increase problem-solving competency, serving model higher-level emerges pool lower-level agents or matter. discuss dynamical ‘waking-up’ collectives, through alignment internal dynamics, might relate reproductive/cell-cycle transitions development.

Язык: Английский

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds DOI Creative Commons
Michael Levin

Frontiers in Systems Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Март 24, 2022

Synthetic biology and bioengineering provide the opportunity to create novel embodied cognitive systems (otherwise known as minds) in a very wide variety of chimeric architectures combining evolved designed material software. These advances are disrupting familiar concepts philosophy mind, require new ways thinking about comparing truly diverse intelligences, whose composition origin not like any available natural model species. In this Perspective, I introduce TAME-Technological Approach Mind Everywhere-a framework for understanding manipulating cognition unconventional substrates. TAME formalizes non-binary (continuous), empirically-based approach strongly agency. provides way think animal sentience an instance collective intelligence cell groups, arising from dynamics that manifest similar numerous other When applied regenerating/developmental systems, suggests perspective on morphogenesis example basal cognition. The deep symmetry between problem-solving anatomical, physiological, transcriptional, 3D (traditional behavioral) spaces drives specific hypotheses by which capacities can increase during evolution. An important medium exploited evolution joining active subunits into greater agents is developmental bioelectricity, implemented pre-neural use ion channels gap junctions scale up cell-level feedback loops anatomical homeostasis. This architecture multi-scale competency biological has implications plasticity bodies minds, greatly potentiating evolvability. Considering classical recent data perspectives computational science, evolutionary biology, cognition, reveals rich research program with many regenerative medicine, artificial intelligence.

Язык: Английский

Процитировано

127

Design for an Individual: Connectionist Approaches to the Evolutionary Transitions in Individuality DOI Creative Commons
Richard A. Watson, Michael Levin, Christopher L. Buckley

и другие.

Frontiers in Ecology and Evolution, Год журнала: 2022, Номер 10

Опубликована: Март 28, 2022

The truly surprising thing about evolution is not how it makes individuals better adapted to their environment, but individuals. All are made of parts that used be themselves, e.g., multicellular organisms from unicellular organisms. In such evolutionary transitions in individuality, the organised structure relationships between component causes them work together, creating a new organismic entity and unit on which selection can act. However, principles these remain poorly understood. particular, process transition must explained by “bottom-up” selection, i.e., existing lower-level units, without presupposing higher-level we trying explain. this hypothesis theory manuscript address conditions for individuality exploiting adaptive already known learning systems. Connectionist models, well-studied neural networks, demonstrate networks functional components, sufficient exhibit information integration collective action, produced via fully-distributed unsupervised principles, centralised control or an external teacher. Evolutionary connectionism translates distributed into domain natural suggests among units could become adaptively below genetic relatedness collectives. manuscript, connectionist models with particular interaction might explain individuality. We explore relationship structures necessary (a) (where whole non-decomposable function parts), (b) development behaviour parts) (c) non-linearly separable functions, familiar output network inputs). Specifically, hypothesise evolve level described learn functions type (or deep model induction) cognition learning.

Язык: Английский

Процитировано

24

Active inference, morphogenesis, and computational psychiatry DOI Creative Commons
Léo Pio-Lopez, Franz Kuchling, Angela Tung

и другие.

Frontiers in Computational Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Ноя. 24, 2022

Active inference is a leading theory in neuroscience that provides simple and neuro-biologically plausible account of how action perception are coupled producing (Bayes) optimal behavior; has been recently used to explain variety psychopathological conditions. In parallel, morphogenesis described as the behavior (non-neural) cellular collective intelligence solving problems anatomical morphospace. this article, we establish link between domains cell biology neuroscience, by analyzing disorders (active) inference. The aim article three-fold. We want to: (i) reveal connection active apparent conditions; (ii) show can be simulated using inference; (iii) suggest shed light on developmental defects or aberrant morphogenetic processes, seen information processing, perhaps suggesting novel intervention repair strategies. present four simulations illustrating application these ideas during morphogenesis. Three same forms (e.g., deficits sensory attenuation low precision) have conditions schizophrenia autism) also produce familiar development when implemented at level group cells. fourth simulation involves two cells with too high precision, which reduction concentration signaling sensitivity signals other treats defect. Finally, results an experimental test one model's predictions early

Язык: Английский

Процитировано

20

The Reasonable Ineffectiveness of Mathematics in the Biological Sciences DOI Creative Commons
Seymour Garte, Perry Marshall, Stuart Kauffman

и другие.

Entropy, Год журнала: 2025, Номер 27(3), С. 280 - 280

Опубликована: Март 7, 2025

The known laws of nature in the physical sciences are well expressed language mathematics, a fact that caused Eugene Wigner to wonder at “unreasonable effectiveness” mathematical concepts explain phenomena. biological sciences, contrast, have resisted formulation precise model complexity living world. limits mathematics biology discussed as stemming from impossibility constructing deterministic “Laplacian” and failure set theory capture creative evolutionary processes biosphere. Indeed, transcends computation. This leads necessity finding new formalisms describe reality, with or without strictly approaches. In former case, expressions do not demand numerical equivalence (equations) provide useful information exact predictions. Examples approximations equal signs given. ineffectiveness is an invitation expand science see creativity formalism.

Язык: Английский

Процитировано

0

Discovering the Impact of Disruption on Creativity, Transformation, and Sustainability DOI
Tshepo Maota,

Vannie Niadoo,

Saad Darwish

и другие.

Studies in big data, Год журнала: 2025, Номер unknown, С. 19 - 29

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

An ability to respond begins with inner alignment: How phase synchronisation effects transitions to higher levels of agency DOI Creative Commons
Tazzio Tissot,

Mike Levin,

Chris Buckley

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 21, 2024

Abstract How do multiple active components at one level of organisation create agential wholes higher levels organisation? For example, in organismic development, how does the multi-scale autonomy organism arise from interactions molecules, cells and tissues that an contains? And, major evolutionary transitions, a multicellular organism, for as unit selective interests its unicellular ancestors? We utilise computational models way to think about this general question. take deliberately minimalistic notion agent: competency two possible actions minimise stress. Helping ourselves behaviour microscale, we focus on conditions where same type agency appears spontaneously organisation. find simple process positive feedback timing individual responses, loosely analogous natural phase synchronisation weakly coupled oscillators, causes such transition behaviour. The emergent collectives become, quite suddenly, able respond their external stresses (minimal) sense original microscale units. This effects dramatic rescaling system behaviour, quantifiable increase problem-solving competency, serving model higher-level emerges pool lower-level agents or matter. discuss dynamical ‘waking-up’ collectives, through alignment internal dynamics, might relate reproductive/cell-cycle transitions development.

Язык: Английский

Процитировано

2