GASTROENTEROLOGY, Год журнала: 2025, Номер 59(1), С. 16 - 22
Опубликована: Март 25, 2025
Background. Gastroesophageal reflux disease (GERD) is a condition that results from the of acidic stomach contents into esophagus and causes heartburn or regurgitation. One key factors in pathogenesis this disruption protective function physiological antireflux barriers esophageal mucosa. Objective: to evaluate effect rebamipide on restoration barrier presence erosive non-erosive forms gastroesophageal young patients. Materials methods. Thirty patients with GERD aged 18 45 years were examined. According upper endoscopy, two groups formed: group I — 15 individuals II people GERD, not associated H.pylori. The control consisted practically healthy individuals. Both took proton pump inhibitors (PPIs) (pantoprazole) standard doses rebamipide for 30 days. participants examined indicators NO system blood plasma before after treatment: general activity total nitric oxide synthase (gNOS), inducible (iNOS), neuronal (nNOS) endothelial (eNOS) NOS; functional surface epithelial cells mucosa was assessed by level sialic acids glycosaminoglycans. Results. Signs dysfunction manifested significant increase iNOS 2.3 times (p = 0.0048) 2.6 0.007) compared group. eNOS 1.2-fold lower than both 0.0005) 0.0007). nNOS increased 1.6-fold 0.04) but its decreased significantly treatment 0.04). Nitrite (NO₂) levels 2.6-fold higher < 0.0001) 1.8-fold 0.0022) normalization acid glycosaminoglycan PPI + complex 0.0001 p 0.0001, respectively) confirmation restorative functions Conclusions. addition monotherapy had advantages terms correcting contributing reduction inflammatory infiltration layer submucosal base mucosa, epithelium, healing erosions, which has an important role reparative processes Although studies regarding mucosal are limited, mechanisms action indicate potential benefit. data obtained may be guidelines further clinical effectiveness disease.
Язык: Английский