Lactiplantibacillus plantarum 1008 Promotes Reproductive Function and Cognitive Activity in Aged Male Mice with High-Fat-Diet-Induced Obesity by Altering Metabolic Parameters and Alleviating Testicular Oxidative Damage, Inflammation and Apoptosis DOI Creative Commons

Chin-Yu Liu,

Tsung-Yu Tsai,

Te-Hua Liu

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1498 - 1498

Опубликована: Дек. 9, 2024

The effects of Lactiplantibacillus plantarum 1008 (LP1008) on age-related cognitive impairment and skeletal muscle atrophy have been reported previously. However, its role in obesity- hypogonadism has yet to be explored. This study investigates the therapeutic efficacy low- high-dose LP1008 a high-fat-diet-fed male mouse model. Mice at 37 weeks age were fed standard diet (n = 8) or 45% high-fat for 28 weeks, mice divided into vehicle, low-dose groups 8 per group) basis treatment administered an additional weeks. We found that suppressed increases total cholesterol levels liver function parameters alleviated histological changes brain, ileum, gastrocnemius testes. In terms reproductive function, attenuated decreases sperm quality, maturity, testosterone enzymes involved biosynthesis. Furthermore, altered impairments spatial learning memory induced slight alterations gut microbiota. Moreover, exerted antioxidant, anti-inflammatory anti-apoptotic aged, obese mice. reversed diet-induced obesity, dysfunction pathological damage by increasing altering microbiome through regulation mediators oxidative stress, apoptosis inflammation.

Язык: Английский

Poly-γ-glutamic acid alleviates slow transit constipation by regulating aquaporin and gut microbes DOI Creative Commons
Xiaoru Wang, Jie Zhou, Zhang‐Hua Sun

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 10, 2025

Slow transit constipation (STC) is a prevalent gastrointestinal disorder caused by colon dysfunction. Poly-γ-glutamic acid (γ-PGA), an anionic polymer known for its moisture retention, degradability, and food safety, was studied effects on loperamide-induced STC in mice. Treatment with γ-PGA one week significantly increased both defecation frequency fecal water content, the high-dose group (10 g/kg/d) restoring content to 34.23%, outperforming low- (16.16%) medium-dose (27.08%) groups exceeding positive control, PEG, 1.35 times. enhanced intestinal peristalsis reduced expression of inflammatory markers (IL-1β, IL-6, caspase-1, TLR2) water-electrolyte transport genes (AQP3, AQP4, ENaC-β), while improving tight junction proteins (Claudin-1, Occludin, ZO-1) damaged loperamide. Histopathological analyses confirmed γ-PGA's capacity repair damage. Additionally, Western Blot analysis indicated AQP3/4 levels colon, molecular docking showed good binding affinity between AQPs. also positively altered gut microbiota composition. Overall, shows promise treating modulating aquaporins microbiota.

Язык: Английский

Процитировано

0
Structural characterization and anti-ageing activity of polysaccharide from Exocarpium Citrulli DOI
Xiaojing Zhang, Ying Liu, Xin Zhang

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер 1316, С. 139073 - 139073

Опубликована: Июнь 22, 2024

Язык: Английский

Процитировано

3
Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using Lactiplantibacillus plantarum TY-Y10 DOI Creative Commons
Shaoqi Shi, Xiaoxia Li, Feng Zhang

и другие.

Foods, Год журнала: 2024, Номер 13(22), С. 3618 - 3618

Опубликована: Ноя. 13, 2024

Oxidative stress is closely linked to aging. Probiotics, whether viable or heat-inactivated, have shown antioxidant properties; however, their effect and mechanism of action in reducing oxidative during aging remains underexplored. This study examined the effects heat-inactivated Lactiplantibacillus plantarum TY-Y10 (L. TY-Y10) on D-galactose (D-gal)-induced mice, aiming uncover potential anti-aging mechanisms. Mice were induced age with D-gal injections, then treated sodium ascorbate (positive control) varying doses L. for eight weeks. After treatment, markers, gut microbiota, liver health analyzed. Results showed that decreased malondialdehyde (MDA) inflammatory markers while increasing levels (glutathione, superoxide dismutase, catalase glutathione peroxidase). Liver damage was reduced, expression Nrf2 related enzymes improved. Additionally, enhanced abundance short-chain fatty acid-producing bacteria, boosting fecal acid levels. In short, both mitigated mice by modulating microbiota activating pathways through gut-liver axis.

Язык: Английский

Процитировано

0
Lactiplantibacillus plantarum 1008 Promotes Reproductive Function and Cognitive Activity in Aged Male Mice with High-Fat-Diet-Induced Obesity by Altering Metabolic Parameters and Alleviating Testicular Oxidative Damage, Inflammation and Apoptosis DOI Creative Commons

Chin-Yu Liu,

Tsung-Yu Tsai,

Te-Hua Liu

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1498 - 1498

Опубликована: Дек. 9, 2024

The effects of Lactiplantibacillus plantarum 1008 (LP1008) on age-related cognitive impairment and skeletal muscle atrophy have been reported previously. However, its role in obesity- hypogonadism has yet to be explored. This study investigates the therapeutic efficacy low- high-dose LP1008 a high-fat-diet-fed male mouse model. Mice at 37 weeks age were fed standard diet (n = 8) or 45% high-fat for 28 weeks, mice divided into vehicle, low-dose groups 8 per group) basis treatment administered an additional weeks. We found that suppressed increases total cholesterol levels liver function parameters alleviated histological changes brain, ileum, gastrocnemius testes. In terms reproductive function, attenuated decreases sperm quality, maturity, testosterone enzymes involved biosynthesis. Furthermore, altered impairments spatial learning memory induced slight alterations gut microbiota. Moreover, exerted antioxidant, anti-inflammatory anti-apoptotic aged, obese mice. reversed diet-induced obesity, dysfunction pathological damage by increasing altering microbiome through regulation mediators oxidative stress, apoptosis inflammation.

Язык: Английский

Процитировано

0