Effects of Black Seed (Nigella sativa L.) on Cardiometabolic Indices in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of RCTs
Complementary Therapies in Medicine,
Год журнала:
2025,
Номер
unknown, С. 103174 - 103174
Опубликована: Апрель 1, 2025
Black
seed
is
known
for
its
health
benefits
in
traditional
medicine.
While
recent
studies
suggest
it
may
improve
cardiometabolic
health,
impact
on
type
2
diabetes
mellitus
(T2DM)
remains
unclear.
This
study
aims
to
meta-analysis
randomized
controlled
trials
(RCTs)
assess
the
effects
of
black
supplementation
indices
T2DM
patients.
Following
PRISMA
guidelines,
a
comprehensive
database
search
was
conducted
up
January
2025,
and
data
were
extracted
from
relevant
RCTs.
Mean
differences
(MD)
standard
deviations
(SD)
analyzed
using
random-effects
model,
heterogeneity
assessed,
publication
bias
evaluated.
The
pooled
16
RCTs
showed
that
significantly
reduced
fasting
blood
glucose
(FBG)
(MD:
-21.43mg/dL;
p=0.005),
hemoglobin
A1c
(HbA1c)
-0.44;
p=0.01),
total
cholesterol
(TC)
-18.80mg/dL;
p=0.04)
low-density
lipoprotein
(LDL)
-19.53mg/dL;
p=0.003).
No
significant
observed
2-hour
postprandial
(2-hpp),
insulin,
homeostatic
model
assessment
(HOMA),
triglycerides
(TG),
high-density
(HDL),
aspartate
aminotransferase
(AST),
alanine
(ALT),
creatinine,
body
weight,
or
mass
index
(BMI).
Subgroup
analyses
revealed
effectively
FBG
longer
than
8
weeks;
additionally,
HbA1c,
HOMA,
LDL
higher
doses
(>1g/day),
shorter
durations
(≤8
weeks),
use
oil
form.
appears
FBG,
TC,
levels
patients
with
T2DM.
However,
no
other
metabolic
parameters,
including
TG,
liver
enzymes,
kidney
function,
weight.
These
findings
be
beneficial
adjunct
therapy
glycemic
lipid
control
but
require
further
research
confirm
broader
effects.
Язык: Английский
Impact of Nigella sativa oil on glycemic control in alloxan-induced diabetic Wistar rats
International Journal of Research in Medical Sciences,
Год журнала:
2024,
Номер
12(8), С. 2762 - 2766
Опубликована: Июль 31, 2024
Background:
To
effectively
manage
diabetes,
it
is
crucial
to
achieve
optimal
glycemic
control
by
ensuring
that
A1C
levels
remain
below
7.0%.
This
study
aimed
investigate
the
impact
of
Nigella
sativa
oil
(black
seed
oil,
BSO)
on
in
alloxan-induced
diabetic
Wistar
rats.
Methods:
Forty
(40)
male
rats
weighing
200-250
gm
were
randomly
allocated
into
eight
(8)
groups
five
(5)
animals
per
group.
Group
1
received
normal
saline
as
normoglycemic
control,
while
2
8
given
alloxan
monohydrate
induce
hyperglycemia,
following
method
Osikwe
et
al.
Following
induction
group
saline,
3
200
mg/kg
metformin,
4
glimepiride,
5
2.5
ml/kg
BSO,
6
glimepiride
and
7
metformin
metformin.
Results:
The
results
showed
BSO
significantly
reduced
fast
blood
glucose
compared
(p<0.05),
lowered
glycosylated
hemoglobin
<7%,
improved
pancreatic
beta
cell
function.
Conclusions:
Black
reduces
fasting
glucose,
exhibits
synergism
with
improves
beta-cell
function
Язык: Английский