The Journal of Infectious Diseases,
Год журнала:
2024,
Номер
231(Supplement_1), С. S1 - S9
Опубликована: Ноя. 19, 2024
Infectious
diseases
(IDs)
contribute
to
major
causes
of
mortality
and
chronic
morbidity
in
Central
South
America.
Interest
improving
general
understanding,
prevention,
treatment
options
motivates
the
U.S.
Department
Defense
establish
run
overseas
ID
institutions
enhance
force
health
protection.
One
6
institutions,
Naval
Research
Medical
Unit
(NAMRU)
SOUTH,
has
safely
ethically
conducted
biomedical
research,
surveillance,
medical
countermeasure
testing
evaluation
Peru
surrounding
countries.
In
its
over
40-year
history,
NAMRU
SOUTH
research
collaborations
have
achieved
many
milestones
leading
critical
information
sharing,
funding,
services,
education
mutually
beneficial
regional
partners
Latin
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
Abstract
As
an
avian
influenza
virus
panzootic
is
underway,
the
threat
of
a
human
pandemic
emerging.
Infections
among
mammalian
species
in
frequent
contact
with
humans
should
be
closely
monitored.
One
family,
Felidae,
particular
concern.
Felids,
known
as
felines
or
cats,
are
susceptible
to
infection.
Felines
prey
on
wild
birds
and
may
serve
host
for
adaptation
mammals.
Feline-to-feline
transmission
has
been
demonstrated
experimentally
[1],
real-world
outbreaks
have
reported
[2,3].
Domestic
cats
popular
companion
animal
thus
provide
potential
pathway
zoonotic
spillover
viruses
humans.
Here,
we
systematic
review
scientific
literature
describe
epidemiology
global
distribution
infections
from
2004
–
2024.
We
aim
comprehensive
background
assessment
current
risk,
well
bring
awareness
recurring
phenomenon
AIV
infection
felines.
New Microbes and New Infections,
Год журнала:
2024,
Номер
60-61, С. 101439 - 101439
Опубликована: Июнь 1, 2024
Avian
influenza
A
H5N1
is
a
significant
global
public
health
threat.
Although
relevant,
systematic
reviews
about
its
prevalence
in
animals
are
lacking.
We
performed
literature
review
bibliographic
databases
to
assess
the
of
animals.
meta-analysis
with
random-effects
model
was
calculate
pooled
and
95%
confidence
intervals
(95%CI).
In
addition,
measures
heterogeneity
(Cochran's
Q
statistic
I2
test)
were
reported.
The
search
yielded
1359
articles,
which
33
studies
fully
valid
for
analysis,
including
96,909
birds
(n=90,045,
234
studies)
5.0%
(95%CI:
4.0-6.0%;
I2=99.21);
pigs
(n=3,178,
4
1.0%
0.0-1.0%);
cats
(n=2,911,
0.0%
dogs
(n=479,
3
0.0-2.0%).
While
occurrence
might
be
comparatively
limited
compared
other
viruses,
impact
on
can
substantial
when
it
transmits
humans.
This
virus
potentially
induce
severe
illness
has
been
linked
previous
outbreaks.
Therefore,
essential
closely
monitor
comprehend
factors
influencing
both
avian
human
populations
develop
effective
disease
control
prevention
strategies.
Microbiology Resource Announcements,
Год журнала:
2024,
Номер
13(9)
Опубликована: Авг. 16, 2024
ABSTRACT
The
panzootic
caused
by
H5N1
avian
influenza
viruses
is
a
high
concern
for
wild
birds’
conservation
and
the
study
of
spillover
events
into
mammals.
near
coding-complete
genome
clade
2.3.3.4b
sequencing
in
Miseq
Illumina
platform
was
performed
from
bird
located
Pantanos
Villa
National
Wildlife
Refuge.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 20, 2024
Abstract
A/goose/Guangdong/1/96-like
(GsGd)
highly
pathogenic
avian
influenza
(HPAI)
H5
viruses
cause
severe
outbreaks
in
poultry
when
introduced.
Since
emergence
1996,
control
measures
most
countries
have
suppressed
local
GsGd
transmission
following
introductions,
making
persistent
domestic
birds
rare.
However,
geographical
expansion
of
clade
2.3.4.4
sublineages
has
raised
concern
about
establishment
endemic
circulation,
while
mechanistic
drivers
leading
to
endemicity
remain
unknown.
We
reconstructed
the
evolutionary
history
sublineage,
2.3.4.4c,
Taiwan
using
a
time-heterogeneous
rate
phylogeographic
model.
During
Taiwan’s
initial
epidemic
wave
(January
2015
-
August
2016),
we
inferred
that
localised
had
multiple
origins
from
rapid
spread
between
counties/cities
nationwide.
Subsequently,
predominantly
originated
single
county,
Yunlin,
where
harbours
trunk
sublineage.
Endemic
hotspots
determined
by
reconstruction
largely
predicted
locations
re-emerging
Yunlin.
The
transition
involved
shift
chicken-dominant
bidirectional
chicken
and
waterfowl.
Our
results
suggest
their
Taiwan,
source-sink
dynamics
county
maintained
endemicity,
pointing
efforts
should
be
targeted
eliminate
disease.
Journal of Virology,
Год журнала:
2024,
Номер
99(1)
Опубликована: Дек. 4, 2024
H5
highly
pathogenic
avian
influenza
(HPAI)
viruses
of
the
A/Goose/Guangdong/1/96
(Gs/Gd)
lineage
continue
to
evolve
and
cause
outbreaks
in
domestic
poultry
wild
birds,
with
sporadic
spillover
infections
mammals.
The
global
spread
clade
2.3.4.4b
via
migratory
birds
since
2020
has
facilitated
introduction
novel
reassortants
China,
where
various
subtypes
have
been
epizootic
or
enzootic
among
birds.
To
determine
impact
re-introduction
on
local
HPAI
dynamics,
we
analyzed
genetic
diversity
H5N6
H5N8
detected
from
monthly
market
surveillance
Guangdong,
between
2022.
Our
findings
reveal
that
clustered
clades
2.3.4.4h,
while
were
exclusively
2.3.4.4b.
After
2020,
re-introduced
replaced
2.3.4.4h
2020.
N6
genes
divided
into
two
clusters,
distinguished
by
an
11
amino
acid
deletion
stalk
region,
N8
2.3.4.4
circulating
Genomic
analysis
identified
10
transient
genotypes.
H5N6,
which
was
more
prevalently
detected,
also
genotypes
than
H5N8.
Specifically,
isolates
contained
derived
H5Nx
low
A(H5N8)
A(H5N1)
2.3.2.1c.
No
positive
selection
residues
associated
mammalian
adaptation
found.
results
suggest
expanded
China
2021
increasing
challenges
for
pandemic
preparedness.IMPORTANCESince
2016/2017,
all
continents
except
Oceania.
Here,
evaluated
virus
China.
Twenty-two
isolated
markets
Guangdong
2022
characterized.
showed
2021-2022.
(n
=
18)
4),
suggesting
may
possess
better
replication
fitness
poultry.
Conversely,
are
largely
bird
isolates.
As
continues
it
is
anticipated
expand
coming
years.
Continuous
efforts
surveillance,
analysis,
risk
assessment
therefore
crucial
preparedness.
The Journal of Infectious Diseases,
Год журнала:
2024,
Номер
231(Supplement_1), С. S1 - S9
Опубликована: Ноя. 19, 2024
Infectious
diseases
(IDs)
contribute
to
major
causes
of
mortality
and
chronic
morbidity
in
Central
South
America.
Interest
improving
general
understanding,
prevention,
treatment
options
motivates
the
U.S.
Department
Defense
establish
run
overseas
ID
institutions
enhance
force
health
protection.
One
6
institutions,
Naval
Research
Medical
Unit
(NAMRU)
SOUTH,
has
safely
ethically
conducted
biomedical
research,
surveillance,
medical
countermeasure
testing
evaluation
Peru
surrounding
countries.
In
its
over
40-year
history,
NAMRU
SOUTH
research
collaborations
have
achieved
many
milestones
leading
critical
information
sharing,
funding,
services,
education
mutually
beneficial
regional
partners
Latin
