Endocrines,
Год журнала:
2024,
Номер
5(3), С. 290 - 303
Опубликована: Июль 23, 2024
While
the
exercise-induced
responses
of
circulated
biomarkers
related
to
inflammation
and
brain
health
are
well
documented
in
humans,
little
is
known
about
effect
menopausal
status
on
these
responses.
This
study
compared
inflammatory
cytokines
brain-derived
neurotrophic
factor
(BDNF)
high-intensity
exercise
between
pre-
postmenopausal
middle-aged
females.
Eight
premenopausal
(44
±
3
years)
seven
(57
2
females
performed
a
interval
training
(HIIT)
session
consisting
10
×
1
min
running
intervals
(90%
maximum
heart
rate)
separated
by
passive
recovery
intervals.
Blood
samples
were
collected
at
baseline
(fasted),
pre-exercise
(postprandial),
0,
30,
90
post-HIIT
analyzed
for
interleukin
(IL-6)
(IL-10),
tumour
necrosis
factor-alpha
(TNF-α),
BDNF.
IL-6
significantly
increased
from
0
(+40%,
p
=
0.01)
30
(+60%,
0.02).
remained
elevated
(+104%,
0.05)
higher
degree
(+385%,
<
0.001).
IL-10
showed
no
response.
TNF-α
(+10%,
0.05),
then
decreased
below
(−10%,
0.02)
(−5%,
0.04)
both
groups.
BDNF
immediately
0.001)
but
not
The
differences
HIIT
provide
evidence
role
female
reproductive
hormones
regulation
The
responses
of
inflammatory
cytokines
and
brain-derived
neurotrophic
factor
(BDNF)
to
a
high-intensity
interval
training
(HIIT)
session
were
compared
between
7
postmenopausal
(57±2
y)
8
premenopausal
females
(44±3
during
the
luteal
phase
their
menstrual
cycle,
when
estrogen
progesterone
are
highest,
and.
HIIT
consisted
10
x
1
min
running
intervals
(90%
maximum
heart
rate)
separated
by
recovery
intervals.
Blood
samples
collected
at
baseline
(fasted),
pre-exercise
(postprandial),
0,
30
90
post-HIIT
analyzed
for
interleukin
(IL-6)
(IL-10),
tumour
necrosis
factor-alpha
(TNF-α)
BDNF.
IL-6
significantly
increased
from
0
in
(+40%,
p=0.01)
but
(+60%,
p=0.02).
remained
elevated
(+104%,
p=0.05)
higher
degree
(+385%,
p&lt;0.001).
IL-10
showed
no
response.
TNF-α
pre-
(+10%,
p=0.05),
then
decreased
below
(-10%,
p=0.02)
(-5%,
p=0.04)
both
groups.
BDNF
immediate
p&lt;0.001)
not
females.
differences
response
pre
provide
evidence
role
female
reproductive
hormones
regulation
these
exercise-induced
responses.
Frontiers in Aging Neuroscience,
Год журнала:
2023,
Номер
15
Опубликована: Сен. 7, 2023
Parkinson's
disease
(PD)
is
a
complex
neurodegenerative
with
an
elusive
etiology
that
involves
the
interaction
between
genetic,
behavioral,
and
environmental
factors.
Recently,
epigenetic
modifications,
particularly
DNA
methylation,
have
been
recognized
to
play
important
role
in
onset
of
PD.
Glycoprotein
non-metastatic
melanoma
protein
B
(GPNMB),
type
I
transmembrane
crucial
for
immune
cell
activation
maturation,
has
emerged
as
potential
biomarker
risk
This
research
aims
investigate
influence
exercise
gender
on
regulation
methylation
levels
GPNMB
cg17274742
individuals.We
analyze
data
from
2,474
participants
Taiwan
Biobank,
collected
2008
2016.
Methylation
at
CpG
site
were
measured
using
Illumina
Infinium
MethylationEPIC
beads.
After
excluding
individuals
incomplete
or
missing
information
possible
factors,
our
final
analysis
included
1,442
participants.
We
used
multiple
linear
regression
models
assess
association
sex
adjusted
age,
BMI,
smoking,
drinking,
coffee
consumption,
serum
uric
acid
levels,
hypertension.Our
results
demonstrated
significantly
influenced
males
(β
=
-0.00242;
p
0.0026),
but
not
females
-0.00002362;
0.9785).
Furthermore,
male
who
exercised
showed
lower
compared
reference
groups
female
non-exercising
-0.00357;
0.0079).
The
effect
was
statistically
significant
(p
0.0078).This
study
suggests
can
modulate
cg17274742,
hypomethylation
observed
men.
More
needed
understand
underlying
mechanisms
implications
these
changes
context
prevention
strategies.
BMJ Open Sport & Exercise Medicine,
Год журнала:
2023,
Номер
9(4), С. e001629 - e001629
Опубликована: Окт. 1, 2023
Introduction
The
global
burden
of
age-related
cognitive
decline
is
increasing,
with
the
number
people
aged
60
and
over
expected
to
double
by
2050.
This
study
compares
acute
effects
age-appropriate
cognitively
demanding
aerobic
exercises
involving
walking,
on
functions
exerkine
responses
such
as
brain-derived
neurotrophic
factor
(BDNF)
cathepsin
B
(CTSB)
in
older,
healthy
adults.
Methods/design
Healthy
older
golfers
(n=25,
16
male
9
female,
69±4
years)
were
enrolled
a
5-day
randomised
cross-over
completed
three
different
exercise
trials
(18-hole
golf
round,
6
km
Nordic
walking)
real-life
environment,
random
order
at
self-selected
pace.
Differences
cognition
(the
Trail-Making
Test
(TMT)
AB)
exerkines
(BDNF
CTSB)
analysed
within
groups
using
Wilcoxon
signed-rank
test
between
Kruskal-Wallis
test.
Results
All
types
resulted
significant
decrease
TMT
A-test
(p<0.05;
golf:
−4.43±1.5
s,
walking:
−4.63±1.6
−6.75±2.26
s),
where
walking
demonstrated
B-test
−9.62±7.2
−7.55±3.2
s).
In
addition,
all
produced
decreases
AB
scores
(p<0.05),
(p=0.035)
showed
TMTB-TMTA-test.
There
no
immediate
postexercise
changes
levels
BDNF
or
CTSB.
Conclusion
Acute
bouts
golf,
improved
irrespective
general
enhanced
executive
functions.
No
seen
Trial
registration
ISRCTN10007294
.
Brain Plasticity,
Год журнала:
2022,
Номер
8(2), С. 153 - 168
Опубликована: Дек. 6, 2022
An
inaugural
workshop
supported
by
"The
Leo
and
Anne
Albert
Charitable
Trust,"
was
held
October
4-7,
2019
in
Scottsdale,
Arizona,
to
focus
on
the
effects
of
exercise
brain
discuss
how
physical
activity
may
prevent
or
delay
onset
aging-related
neurodegenerative
conditions.
The
Scientific
Program
Committee
(led
Dr.
Jeff
Burns)
assembled
translational,
clinical,
basic
scientists
who
research
various
aspects
body
brain,
with
overall
goal
gaining
a
better
understanding
as
diseases.
In
particular,
topics
included
links
between
cardiorespiratory
fitness,
cerebrovasculature,
energy
metabolism,
peripheral
organs,
cognitive
function,
which
are
all
highly
relevant
acute
chronic
brain.
Trust
participants
addressed
these
related
topics,
well
other
lifestyle
interventions,
such
diet,
affect
age-related
decline
associated
Alzheimer's
This
report
provides
synopsis
presentations
discussions
participants,
delineation
next
steps
towards
advancing
our
aging
Redox Biology,
Год журнала:
2024,
Номер
75, С. 103300 - 103300
Опубликована: Авг. 10, 2024
Glyoxalase
I
(GLO1)
is
the
primary
enzyme
for
detoxification
of
reactive
dicarbonyl
methylglyoxal
(MG).
Loss
GLO1
promotes
accumulation
MG
resulting
in
a
recapitulation
diabetic
phenotypes.
We
previously
demonstrated
attenuated
protein
skeletal
muscle
from
individuals
with
type
2
diabetes
(T2D).
However,
whether
attenuation
occurs
prior
to
T2D
and
mechanisms
regulating
abundance
are
unknown.
expression
activity
were
determined
tissue
biopsies
15
lean
healthy
(LH,
BMI:
22.4
±
0.7)
5
obesity
(OB,
32.4
1.3).
was
by
26
0.3
%
OB
compared
LH
(p
=
0.019).
Similar
reductions
observed
0.102).
NRF2
Keap1
equivocal
between
groups
despite
2-fold
elevation
transcripts
0.008).
knock-down
(KD)
human
immortalized
myotubes
promoted
downregulation
contraction
organization
proteins
indicating
importance
function.
SIRT1
KD
had
no
effect
on
or
whereas,
SIRT2
28
0.29
<
0.0001)
42
0.12
0.0150).
NAMPT
also
resulted
(28
0.069
%,
p
0.003),
(67
0.09
0.011)
(50
0.13
0.049).
Neither
provision
NAD
Abstract
Frailty
is
characterized
by
loss
of
physical
function
and
preferably
diagnosed
at
an
early
stage
(e.g.,
during
pre-frailty).
Unfortunately,
sensitive
tools
that
can
aid
detection
are
lacking.
Blood-based
biomarkers,
reflecting
pathophysiological
adaptations
before
symptoms
become
apparent,
could
be
such
tools.
We
identified
candidate
biomarkers
using
a
mechanism-based
computational
approach
which
integrates
priori
defined
database-derived
clinical
skeletal
muscle
transcriptome
data.
Identified
were
used
as
input
for
sex-specific
correlation
analysis,
individual
gene
expression
data
from
female
(
n
=
24)
male
28)
older
adults
(all
75
+
years,
ranging
fit
to
pre-frail)
three
frailty-related
parameters.
Male
groups
matched
based
on
age,
BMI,
Fried
frailty
index.
The
best
correlating
evaluated,
selected
measured
in
serum.
In
females,
myostatin
galectin-1
and,
males,
cathepsin
B
thrombospondin-4
serum
levels
significantly
different
between
the
physically
weakest
fittest
participants
p
<
0.05).
Logistic
regression
confirmed
added
value
these
conjunction
with
age
BMI
predict
whether
subjects
belonged
weaker
or
group
(AUC
0.80
females
AUC
0.83
males).
conclusion,
both
silico
vivo
analyses
revealed
sex-specificity
we
selection
potential
biomarker
panel
frailty.
Further
investigation
needed
confirm
leads
Endocrines,
Год журнала:
2024,
Номер
5(3), С. 290 - 303
Опубликована: Июль 23, 2024
While
the
exercise-induced
responses
of
circulated
biomarkers
related
to
inflammation
and
brain
health
are
well
documented
in
humans,
little
is
known
about
effect
menopausal
status
on
these
responses.
This
study
compared
inflammatory
cytokines
brain-derived
neurotrophic
factor
(BDNF)
high-intensity
exercise
between
pre-
postmenopausal
middle-aged
females.
Eight
premenopausal
(44
±
3
years)
seven
(57
2
females
performed
a
interval
training
(HIIT)
session
consisting
10
×
1
min
running
intervals
(90%
maximum
heart
rate)
separated
by
passive
recovery
intervals.
Blood
samples
were
collected
at
baseline
(fasted),
pre-exercise
(postprandial),
0,
30,
90
post-HIIT
analyzed
for
interleukin
(IL-6)
(IL-10),
tumour
necrosis
factor-alpha
(TNF-α),
BDNF.
IL-6
significantly
increased
from
0
(+40%,
p
=
0.01)
30
(+60%,
0.02).
remained
elevated
(+104%,
0.05)
higher
degree
(+385%,
<
0.001).
IL-10
showed
no
response.
TNF-α
(+10%,
0.05),
then
decreased
below
(−10%,
0.02)
(−5%,
0.04)
both
groups.
BDNF
immediately
0.001)
but
not
The
differences
HIIT
provide
evidence
role
female
reproductive
hormones
regulation
