Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age

Biomolecules, Год журнала: 2022, Номер 12(3), С. 371 - 371

Опубликована: Фев. 25, 2022

Alzheimer’s and Parkinson’s diseases are the two most common forms of neurodegenerative diseases. The exact etiology these disorders is not well known; however, environmental, molecular, genetic influences play a major role in pathogenesis Using disease (AD) as archetype, pathological findings include aggregation Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), cerebrovascular dysregulation. This review highlights neuroinflammatory neuroprotective epigallocatechin-3-gallate (EGCG): medicinal component green tea, known nutraceutical that has shown promise modulating AD progression due to its antioxidant, anti-inflammatory, anti-aging abilities. report also re-examines current literature provides innovative approaches for EGCG be used preventive measure alleviate other disorders.

Язык: Английский

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Past, Present and (Foreseeable) Future of Biological Anti-TNF Alpha Therapy

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(4), С. 1630 - 1630

Опубликована: Фев. 17, 2023

Due to the key role of tumor necrosis factor-alpha (TNF-α) in pathogenesis immunoinflammatory diseases, TNF-α inhibitors have been successfully developed and used clinical treatment autoimmune disorders. Currently, five anti-TNF-α drugs approved: infliximab, adalimumab, golimumab, certolizumab pegol etanercept. Anti-TNF-α biosimilars are also available for use. Here, we will review historical development as well present potential future applications therapies, which led major improvements patients with several such rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn’s disease (CD), ulcerative colitis (UC), psoriasis (PS) chronic endogenous uveitis. Other therapeutic areas under evaluation, including viral infections, e.g., COVID-19, neuropsychiatric disorders certain forms cancer. The search biomarkers able predict responsiveness is discussed.

Язык: Английский

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Pathological changes within the cerebral vasculature in Alzheimer’s disease: New perspectives

Brain Pathology, Год журнала: 2022, Номер 32(6)

Опубликована: Март 14, 2022

Abstract Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional changes to the cerebral vasculature contribute pathology cognitive decline in Alzheimer's (AD). In this review, we discuss contribution of amyloid angiopathy non‐amyloid small vessel AD, accompanying density, maintenance remodelling vessels (including alterations composition function cerebrovascular basement membrane). We consider how abnormalities constituent cells neurovascular unit – particularly endothelial pericytes impairment blood‐brain barrier (BBB) impact on pathogenesis AD. also are likely impair Aβ clearance both intra‐periarteriolar drainage (IPAD) transport peptides across BBB, impaired coupling reduced blood flow relation metabolic demand increase amyloidogenic processing APP production Aβ. review vasoactive properties themselves, probable bi‐directional relationship between dysfunction accumulation Lastly, recent methodological advances transcriptomics imaging that have provided novel insights into assessment retina allow vivo detection early stages

Язык: Английский

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The relationship between inflammatory biomarkers and cognitive dysfunction in patients with schizophrenia: A systematic review and meta-analysis

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2022, Номер 121, С. 110668 - 110668

Опубликована: Окт. 23, 2022

Язык: Английский

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Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin

Neuronal Signaling, Год журнала: 2023, Номер 7(2)

Опубликована: Июнь 26, 2023

Abstract There are several hypotheses concerning the underlying pathophysiological mechanisms of major depression, which centre largely around adaptive changes in neuronal transmission and plasticity, neurogenesis, circuit regional connectivity. The immune endocrine systems commonly implicated driving these changes. An intricate interaction stress hormones, innate cells actions soluble mediators immunity within nervous system is described as being associated with symptoms depression. Bridging processes to neurotransmission signalling key cortical limbic brain circuits critical understanding depression a disorder neuroimmune origins. Emergent areas research include growing recognition system, advances neuroimaging techniques mechanistic insights gained from transgenic animals. Elucidation glial–neuronal interactions providing additional avenues into promising research, development clinically relevant disease models discovery novel therapies. This narrative review focuses on molecular cellular that influenced by inflammation stress. aim this provide an overview our current origin, focusing neuroendocrine dysregulation pathophysiology. Advances lie pursuit biomarkers, potential biomarker signatures improve clinical outcomes yet be fully realised. Further investigations expand panels including integration neuroimaging, utilising individual stratify patients more homogenous subpopulations targeting for new treatment approaches will help address unmet need.

Язык: Английский

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Roles of Cytokines in Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5803 - 5803

Опубликована: Май 26, 2024

The neuroimmune system is a collection of immune cells, cytokines, and the glymphatic that plays pivotal role in pathogenesis progression Alzheimer’s disease (AD). Of particular focus are group signaling molecules facilitate communication among cells contribute to inflammation AD. Extensive research has shown dysregulated secretion certain cytokines (IL-1β, IL-17, IL-12, IL-23, IL-6, TNF-α) promotes neuroinflammation exacerbates neuronal damage However, anti-inflammatory (IL-2, IL-3, IL-33, IL-35) also secreted during AD onset progression, thereby preventing neuroinflammation. This review summarizes involvement pro- pathology discusses their therapeutic potential.

Язык: Английский

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TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG

Theranostics, Год журнала: 2021, Номер 11(19), С. 9452 - 9469

Опубликована: Янв. 1, 2021

Background: Neuronal death is a major hallmark of Alzheimer's disease (AD). Necroptosis, as programmed necrotic process, activated in AD. However, what signals and factors initiate necroptosis AD largely unknown. Methods: We examined the expression levels critical molecules necroptotic signaling pathway by immunohistochemistry (IHC) staining immunoblotting using brain tissues from patients mouse models APP/PS1 5×FAD. performed stereotaxic injection with recombinant TNF-α, anti-TNFR1 neutralizing antibody or AAV-mediated gene knockdown mice. For vitro studies, we used TNF-α combined zVAD-fmk Smac mimetic to establish neuronal utilized pharmacological molecular biological approaches study pathways. Results: find that dependent on upstream TNF-α/TNFR1 both cell cultures models. Upon stimulation, accumulated p62 recruits RIPK1 induces its self-oligomerization, activates downstream RIPK1/RIPK3/MLKL cascade, leading necroptosis. Ectopic accumulation caused impaired autophagy flux, which mediated UVRAG downregulation during TNF-α-promoted Notably, overexpression inhibits Conclusions: identify finely controlled regulation coordinated signaling, RIPK1/3 activity machinery. Strategies could fine-tune may bring promising therapeutics for

Язык: Английский

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Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders

Antioxidants, Год журнала: 2022, Номер 11(5), С. 923 - 923

Опубликована: Май 8, 2022

The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous under stress conditions. HO degrades carbon monoxide, iron, and biliverdin. These degradation products are involved in modulating cellular redox homeostasis. first identified isoform of system, HO-1, an inducible protein that highly expressed peripheral organs barely detectable brain normal conditions, whereas HO-2 constitutive brain. Several lines evidence indicate HO-1 dysregulation associated with inflammation neurodegeneration, including Parkinson’s Alzheimer’s diseases. In this review, we summarize essential roles plays ensuring health molecular through which dysfunction leads neurodegenerative diseases disruption We also provide summary herbal medicines regulation expression explore current situation regarding remedies disorders.

Язык: Английский

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Role of pro-inflammatory cytokines in Alzheimer's disease and neuroprotective effects of pegylated self-assembled nanoscaffolds

Current Research in Pharmacology and Drug Discovery, Год журнала: 2022, Номер 4, С. 100149 - 100149

Опубликована: Дек. 20, 2022

Neurodegeneration and synaptic loss in Alzheimer's disease (AD) lead to impairment memory functions. Neuroinflammation causes activation of microglia astrocytes cells that locally systemically produces inflammatory cytokines which can serve as early diagnostic markers or therapeutic targets AD. Pro-inflammatory (Interleukins (IL-1β, IL-6 IL-10) tumor necrosis factor (TNF α)) levels were estimated serum, cerebral tissue, hepatic renal tissue treatment groups scopolamine-induced amnesia mice model using ELISA protocol. The results showed AD exhibited elevated IL1β, IL6, IL10 TNFα indicate contribution pro-inflammatory the progression A significant reduction concentration IL-10 TNF-α noticed animal group treated with marketed memantine tablet (Admenta), pure drug (MEMp), memantine-poly (lactic-co-glycolic acid) self-assembled nanoscaffolds (MEM-PLGA) SANs, Polyethylene Glycol coated [(PEG-MEM-PLGA) SANs] [(lactic-co-glycolic acid)] grafted Bone Marrow Derived Stem Cell ((PEG-MEM-PLGA) SANs-BMSc), whereas a high level was observed tissues normal induced emerging potential trigger either neurons survival after injury causing neurodegeneration cell apoptosis. Neuroregenerative stem helps proliferation neuronal thus improves cognition model.

Язык: Английский

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Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis

Kidney Diseases, Год журнала: 2022, Номер 8(4), С. 275 - 285

Опубликована: Янв. 1, 2022

Cognitive impairment, increasingly recognized as a major social burden, is commonly found in chronic kidney disease (CKD) patients.

Язык: Английский

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