The bidirectional associations between sarcopenia-related traits and cognitive performance

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 31, 2024

Abstract While many studies have sought to explore the degree which sarcopenia-related traits are associated with cognitive performance, these yielded contradictory results without any clear indication of causality such relationships. In efforts better understand associations between and ability, a series multivariate linear regression assessments were carried out upon datasets derived through National Health Nutrition Examination Survey (NHANES). Of these, performance was assessed by Digit Symbol Substitution Test (DDST), Consortium Establish Registry for Alzheimer’s Disease Immediate Recall (CERAD-IR), Delayed (CERAD-DR) Animal Fluency (AFT). Causal relationships two further inferred via two-sample Mendelian randomization (MR) analysis approach. Sarcopenia-related considered in included walking speed, appendicular skeletal muscle mass (ASM), hand grip strength (HGS). Walking ASM, HGS all significantly independently related scores following adjustment covariates. MR also identified that each 1-SD higher speed lean causally respectively 0.34 [standard error (SE) = 0.09; p < 0.001)] standardized score 0.07 (SE 0.01; 0.001) score, whereas positively performance. Reverse similar findings. These data suggest lower strength, closely irrespective gender, there may be mutually reinforcing relationship among variables.

Язык: Английский

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Association between Handgrip Strength and the Systemic Immune-Inflammation Index: A Nationwide Study, NHANES 2011–2014

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(20), С. 13616 - 13616

Опубликована: Окт. 20, 2022

(1) Background: The Systemic immune-inflammatory index (SII) has been proven to be an effective biomarker of human immune and inflammatory levels prognostic significance for most diseases. Handgrip strength (HGS) is a simple low-cost measurement method, which not only highly correlated with overall muscle but also accurately reliably predicts the risk multiple chronic diseases mortality; (2) Purpose: Association between HGS SII unclear. purpose this study was investigate association in American adults; (3) Methods: We used data from 2011–2012 2013–2014 cycles National Health Nutrition Examination Survey (NHANES), involving total 8232 adults (aged 18–80 years). calculated as Platelet count × Neutrophil count/Lymphocyte count; recorded ratio sum highest grip-strength values each hand body mass taken relative grip strength. A weighted generalized linear regression model analysis restricted cubic spline regression, adjusted confounding factors, were assess associations (4) Results: There negative correlation different sexes (p < 0.05), there significant nonlinear relationship males = 0.0035), showed downward trend increase (Q2: β −61.03, p 0.01; Q3: −61.28, 0.04, Q4: −64.36, 0.03, 0.04), when exceeds 3.16, increasing, increasing slowed down. females 0.1011), −24.91, 0.25; −62.01, −74.94, 0.01); (5) Conclusions: inversely independently associated levels, although limited gender differences, genders consistent, both showing that decreased HGS. In addition, high general applicability based on its ease measurement; it possible understand one’s own level through routine tests, make preliminary predictions current immunity inflammation body.

Язык: Английский

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Longitudinal relationship between grip strength and cognitive function in a European population older than 50 years: A cross-lagged panel model

Archives of Gerontology and Geriatrics, Год журнала: 2024, Номер 122, С. 105396 - 105396

Опубликована: Март 5, 2024

Язык: Английский

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Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hand grip strength in U.S. adults

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 19, 2025

Non-high-density lipoprotein cholesterol to high-density ratio (NHHR) is an indicator of imbalance in lipid metabolism and has been associated with a variety metabolic diseases. Hand Grip Strength (HGS) important for assessing muscle function overall health. The aim this study was investigate the relationship between NHHR HGS, revealing how affects strength may provide early indication health dysfunction. We collected demographic clinical data from 6,573 adults aged 20-60 years National Health Nutrition Examination Survey (NHANES) database 2011 2014.NHHR defined as total minus levels (HDL-C) divided by HDL-C. HGS expressed relative grip sum maximum readings each hand/body mass index ratio. Among analysis techniques used were multifactor linear regression, smoothed curve fitting, subgroups, interactions. There negative correlation 6573 participants included. After adjusting all covariates, unit increase log2-NHHR 0.28 [-0.28 (-0.31, -0.26)] decrease remained stable across subgroups (p < 0.01 test trend). analyses also identified nonlinear association inflection point 1.74. Interaction tests showed that differed significantly age, gender, stratification diabetes status. Our suggests there be U.S. Considering decline manifestation sarcopenia, it relevant prevention control sarcopenia through close detection management NHHR.

Язык: Английский

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The Effect of Aerobic or Strength Training in Elderly with Cognitive Decline: The Fit4Alz Project

Journal of Sports Science and Medicine, Год журнала: 2025, Номер unknown, С. 172 - 186

Опубликована: Фев. 24, 2025

This study aimed to examine the effects of aerobic and strength training methodologies, either combined with or without cognitive training, on mitigating decline. A total 154 subjects were recruited (72.8 ± 6.1 years, 69% females) divided into four groups: i) plus (STCT, n = 56); ii) (ST, 23); iii) (AT, 41); iv) (ATCT, 34). Subjects previously cognitively assessed showed decline (less than 26 points Montreal Cognitive Assessment, MoCA). For 12 weeks, all groups performed 3 times a week, for 60 minutes, program corresponding their attributed group. The MoCA test Senior Fitness applied at beginning end intervention. repeated-measures ANCOVA revealed significant time-by-group interactions physical performance measures, including 2-minute step-in-place (p 0.026), arm curl < 0.001), chair sit-and-reach back-scratch 8-foot up-and-go 6-minute walk tests 0.001). However, no improvements observed function (MoCA, p 0.242) lower body (chair stand, 0.411). AT group greater in upper compared STCT ST 0.001; d 0.698; 0.004; 0.598), while significantly improved flexibility ATCT 1.049). had greatest endurance 0.133; 0.350). It was demonstrated that overall elderly individuals. performance. Although these findings suggest both exercise, improve fitness, further research is needed determine its impact

Язык: Английский

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Association of Physical Frailty and Cognitive Function in a Population-Based Cross-Sectional Study of American Older Adults

Gerontology, Год журнала: 2023, Номер 70(1), С. 48 - 58

Опубликована: Окт. 30, 2023

Cognitive impairment and frailty are prevalent in older persons. Physical is associated with cognitive decline; however, the role of effect modifiers such as age, sex, race/ethnicity, reserve not well understood.

Язык: Английский

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Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal study (CHARLS)

Journal of the Formosan Medical Association, Год журнала: 2024, Номер unknown

Опубликована: Апрель 1, 2024

As the population ages, concerns about cognitive decline have become increasingly relevant in medical consultations. This study aims to analyze interaction between muscle strength, lung function, and function Chinese middle-aged older adults, providing a theoretical basis for better prevention of decline. used data from China Health Retirement Longitudinal Study (CHARLS) wave 3, including 13 716 participants aged 45 years or older. Cognitive was assessed through two dimensions, resulting total score ranging 0 31 points, with higher scores indicating function. Muscle strength measured using normalized grip chair-standing time, while evaluated peak expiratory flow (PEF). Total exhibited significant correlations PEF. demonstrated associations emerging as notable mediating factor. relationship persisted even after adjusting potential confounding variables. Specifically, PEF played substantial role linking (estimated indirect effect = 0.0132, boot-strapped standard error 0.0015, 95% confidence interval 0.0104, 0.0162). Additionally, served mediator association time −0.0204, 0.0023, −0.0251, −0.0159). The highlights importance addressing declines identify risk factors associated Understanding these relationships can provide insights into pathways variables may aid Further long-term longitudinal cohort studies are needed explore causality factors.

Язык: Английский

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The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats

Aging, Год журнала: 2024, Номер unknown

Опубликована: Апрель 12, 2024

Studies suggest that ketogenic diets (KD) may improve memory in mouse models of aging and Alzheimer's disease (AD). This study determined whether a continuous or intermittent KD (IKD) enhanced cognitive behavior the TgF344-AD rat model AD. At 6 months-old, wild-type (WT) littermates were placed on control (CD), KD, IKD (morning CD afternoon KD) provided as two meals per day for 2 months. Cognitive motor circulating β-hydroxybutyrate (BHB), AD biomarkers blood lipids assessed. Animals diet had elevated BHB, with levels intermediate to KD. rats displayed impaired spatial learning Barnes maze at 8 12 months age coordination age. Neither nor improved performance compared CD. age, animals lipids. reduced WT further reducing cholesterol below levels. shows intervention did not measures rats; however, both positively impacted

Язык: Английский

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Association between handgrip strength asymmetry and cognitive function across ethnicity in rural China: a cross-sectional study

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Май 19, 2023

Recently, the association between handgrip strength (HGS) asymmetry and cognition has been revealed, but evidences are still scarce. Particularly, asymmetric HGS cognitive performance in various domains is unclear whether this stable across ethnic groups unknown.The population was from a longitudinal study rural areas of Fuxin, Liaoning, China. The Chinese version Montreal Cognitive Assessment-Basic (MOCA-BC) used to evaluate function. ratio calculated as maximal non-dominant divided by dominant HGS. <0.9 or >1.1 classified dominant/non-dominant HGS, respectively. Generalized linear models were analyze relationship function adjusted for handedness, wave, age, sex, education, ethnicity, smoking, drinking, physical labor level, BMI, hypertension, diabetes dyslipidemia.A total 2,969 participants ≥50 years included study. Adjusted other confunding variables, there an inverted U-shaped MoCA-BC scores (Pnon-linear = 0.004). inconsistent among (Pinteraction 0.048). In Han, only associated with lower [β -0.67, 95% confidence interval (CI): -1.26 ∼-0.08, P 0.027]; Mongolians, HGS(β -0.60, CI: -1.35 ∼ 0.15, 0.115) (β -0.56, -1.42 0.31, 0.206) all scores, although no statistical significance found. Asymmetric not independently impairment Delayed Recall (OR 1.35, 1.05 1.74; OR per 5 kg decrease 1.10, 1.01 1.21) Fluency 1.43, 1.15 1.78; 1.02 1.19). Both 1.34, 1.07 1.67) 1.21, 1.10 1.32) visuoperception.HGS related global performance. varies groups.

Язык: Английский

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Exploring the role of vitamin D in cognitive function: mediation by depression with diabetes modulation in older U.S. adults, a NHANES weighted analysis

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 4, 2024

Background The relationship between vitamin D levels, depressive symptoms, and cognitive function has yet to be definitively understood in the elderly, particularly when considering impact of chronic diseases. This study focuses on how depression mediates 25-hydroxyvitamin D3 (25(OH)D3) performance older U.S. adults. Methods We analyzed data from 2,745 elderly individuals extracted NHANES 2011–2014 cycles, applying weighted processing account for complex multi-stage sampling design characteristic data. Utilizing covariate model selection, we conducted mediation analyses both overall population subgroup Significant pathways were validated using a stratified bootstrap approach. For significant pathways, explored interactive mechanisms through analysis. Results Mediation analyses, thoroughly accounting conditions, revealed diabetes subgroup. After 1,000 replications, proportion effects 10.6% [0.040, 0.268] 20.9% [0.075, 0.663], respectively. Interactive analysis indicated that interaction was not direct pathway (estimates = 0.050, p 0.113) but pathway, yielding largest effect size compared other covariates 0.981, &lt; 0.001). Conclusion highlights mediating role levels emphasizing as key moderator. Our findings suggest targeted interventions addressing sufficiency could significantly benefit health, especially diabetic individuals.

Язык: Английский

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