International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(13), С. 11119 - 11119
Опубликована: Июль 5, 2023
We
recently
developed
a
multiplex
diagnostic
kit,
QPLEX™
Alz
plus
assay
which
captures
amyloid-β1-40,
galectin-3
binding
protein,
angiotensin-converting
enzyme,
and
periostin
simultaneously
using
microliters
of
peripheral
blood
utilizes
an
optimized
algorithm
for
screening
Alzheimer’s
disease
(AD)
by
correlating
with
cerebral
amyloid
deposition.
Owing
to
the
demand
early
AD
detection,
we
investigate
potential
our
kit
clinical
diagnosis
AD.
A
total
1395
participants
were
recruited,
their
samples
analyzed
kit.
The
average
values
in
each
group
increased
gradually
order
progression
continuum
AD:
cognitively
normal
(0.382
±
0.150),
subjective
cognitive
decline
(0.452
0.130),
mild
impairment
(0.484
0.129),
(0.513
0.136).
between
showed
statistically
significant
differences
among
groups
divided
Mini-Mental
State
Examination
Clinical
Dementia
Rating.
could
be
used
distinguish
or
function.
Because
blood-based
is
more
accessible,
convenient,
cost-
time-effective
than
spinal
fluid
positron
emission
tomography
imaging-based
diagnosis,
can
potentially
health
checkups
Aging Clinical and Experimental Research,
Год журнала:
2024,
Номер
36(1)
Опубликована: Авг. 7, 2024
A
low
handgrip
strength
(HGS)
is
a
significant
risk
factor
for
multiple
diseases.
However,
most
relevant
studies
investigate
the
complications
of
HGS,
while
potential
causative
factors
HGS
remain
poorly
characterized.
Journal of the Oman Medical Association,
Год журнала:
2025,
Номер
2(1), С. 3 - 3
Опубликована: Фев. 6, 2025
Burn
injuries
cause
severe
muscle
wasting
and
weakness.
However,
the
relative
contribution
of
neuromuscular
junction
(NMJ)
degradation
remains
elusive.
We
investigated
associations
plasma
c-terminal
agrin
fragment-22
(CAF22),
a
marker
NMJ
degradation,
with
decline
in
burn
patients.
recruited
male
patients
burns
(n
=
32,
age
32.3
±
4.5
years,
percent
area
15.2
2.3)
age-matched
controls
to
evaluate
handgrip
strength
(HGS),
skeletal
mass
index
(SMI),
phase
angle,
creatine
kinase
levels
CAF22,
c-reactive
protein,
8-isoprostanes.
used
an
unpaired
t-test
regression
analysis
for
statistics.
The
had
lower
HGS,
SMI,
angle
than
(all
p
<
0.05).
These
also
exhibited
higher
CRP,
8-isoprostanes,
0.05),
suggesting
heightened
inflammation
oxidative
stress.
Correlation
revealed
significant
correlations
CAF22
HGS
patients,
potential
contributions
weakness
atrophy
(both
found
CRP
these
Altogether,
appears
play
role
burn-induced
injury
may
warrant
further
investigation
therapeutic
interventions.
Aging Clinical and Experimental Research,
Год журнала:
2025,
Номер
37(1)
Опубликована: Март 17, 2025
Abstract
Background
A
low
handgrip
strength
(HGS)
is
associated
with
several
diseases
in
older
adults.
However,
predictive
biomarkers
of
future
HGS
are
poorly
known.
We
investigated
the
prognostic
efficacy
ratio
plasma
cystatin-c
and
total
cholesterol
(CT
ratio)
levels
for
predicting
Europe.
Methods
The
data
was
collected
from
Survey
Health,
Ageing,
Retirement
Europe
(SHARE)
between
2015
2021-22.
study
participants
were
geriatric
adults
aged
50
or
above
(
n
=
17,698)
12
European
countries.
baseline
included
measurements
CT
normal
HGS.
who
developed
subsequent
years
included.
also
quality
life,
difficulties
performing
daily
activities,
comorbidities
population.
Results
In
a
multivariate-adjusted
model,
male
gender,
advancing
age,
poor
presence
depression,
high
blood
pressure,
diabetes
mellitus,
Alzheimer’s
disease,
osteoarthritis
higher
risk
developing
exhibited
significant
accuracy
among
men
women
60–79,
irrespective
degree
comorbidities,
including
osteoarthritis.
Conclusion
Collectively,
exhibits
adequate
HGS,
which
not
significantly
affected
by
functional
limitations.
Our
findings
have
clinical
policy
implications
timely
identifying
at
