Interactions between menopause and high‐fat diet on cognition and pathology in a mouse model of Alzheimer's disease DOI Creative Commons
Charly Abi‐Ghanem, Richard D. Kelly,

Emily Groom

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(3)

Опубликована: Март 1, 2025

Abstract INTRODUCTION Post‐menopausal women constitute about two‐thirds of those with Alzheimer's disease (AD). Menopause increases dementia risk by heightening the likelihood metabolic disease, a well‐known factor for dementia. We aimed to determine effects menopause and high‐fat diet (HF) on cognitive pathological outcomes in an AD mouse model. METHODS At 3 months old, App NL‐F mice received 4‐vinylcyclohexene diepoxide (menopause model) or vehicle were placed control (10% fat) HF (60% until 10 old. RESULTS An interaction between led impaired recognition memory. No observed amyloid pathology. However, induced alterations microglial response, white matter, hippocampal neurogenesis. DISCUSSION This work highlights need model endocrine aging animal models contributes further understanding health context AD. Highlights The combination early onset impairment. increased pathology hippocampus. increase microglia density decrease myelin corpus callosum. altered neurogenesis diet‐dependent manner.

Язык: Английский

Interactions between menopause and high‐fat diet on cognition and pathology in a mouse model of Alzheimer's disease DOI Creative Commons
Charly Abi‐Ghanem, Richard D. Kelly,

Emily Groom

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(3)

Опубликована: Март 1, 2025

Abstract INTRODUCTION Post‐menopausal women constitute about two‐thirds of those with Alzheimer's disease (AD). Menopause increases dementia risk by heightening the likelihood metabolic disease, a well‐known factor for dementia. We aimed to determine effects menopause and high‐fat diet (HF) on cognitive pathological outcomes in an AD mouse model. METHODS At 3 months old, App NL‐F mice received 4‐vinylcyclohexene diepoxide (menopause model) or vehicle were placed control (10% fat) HF (60% until 10 old. RESULTS An interaction between led impaired recognition memory. No observed amyloid pathology. However, induced alterations microglial response, white matter, hippocampal neurogenesis. DISCUSSION This work highlights need model endocrine aging animal models contributes further understanding health context AD. Highlights The combination early onset impairment. increased pathology hippocampus. increase microglia density decrease myelin corpus callosum. altered neurogenesis diet‐dependent manner.

Язык: Английский

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