Brain lncRNA-mRNA co-expression regulatory networks and alcohol use disorder
Genomics,
Год журнала:
2024,
Номер
116(5), С. 110928 - 110928
Опубликована: Авг. 26, 2024
Prolonged
alcohol
consumption
can
disturb
the
expression
of
both
coding
and
noncoding
genes
in
brain.
These
dysregulated
may
co-express
modules
interact
within
networks,
consequently
influencing
susceptibility
to
developing
use
disorder
(AUD).
In
present
study,
we
performed
an
RNA-seq
analysis
long
RNAs
(lncRNAs)
messenger
(mRNAs)
192
postmortem
tissue
samples
collected
from
eight
brain
regions
(amygdala,
caudate
nucleus,
cerebellum,
hippocampus,
nucleus
accumbens,
prefrontal
cortex,
putamen,
ventral
tegmental
area)
12
AUD
control
subjects
European
ancestry.
Applying
limma-voom
method,
detected
a
total
57
lncRNAs
51
mRNAs
exhibiting
significant
differential
(P
Язык: Английский
Enhancing Alzheimer’s Disease Diagnosis and Care by Focusing on Plasma Biomarkers for Identifying Mild Cognitive Impairment
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
101(3), С. 731 - 734
Опубликована: Сен. 3, 2024
Biomarkers
that
accurately
identify
mild
cognitive
impairment
(MCI)
are
of
greater
importance
for
Alzheimer's
disease
(AD)
management
and
treatment.
On
the
other
hand,
blood-based
biomarkers
not
only
more
practical
but
also
less
invasive
than
common
cerebrospinal
fluid
biomarkers.
In
their
report
in
Journal
Disease,
Wang
collaborators
identified
67
upregulated
220
downregulated
long
noncoding
RNAs
(lncRNAs).
They
further
demonstrated
4
these
lncRNAs
could
discriminate
MCI
from
cognitively
healthy
individuals.
Apart
significance
as
potential
diagnosis,
can
offer
additional
information
on
cellular
mechanisms
AD
pathology.
Язык: Английский