Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent
Frontiers in Molecular Neuroscience,
Год журнала:
2025,
Номер
18
Опубликована: Янв. 27, 2025
Reelin
is
a
secreted
glycoprotein
that
was
initially
investigated
in
the
field
of
neuronal
development.
However,
recent
decades,
its
role
adult
brain
has
become
increasingly
important,
and
it
now
clear
diminished
function
involved
pathogenesis
progression
neuropsychiatric
neurodegenerative
disorders,
including
schizophrenia
Alzheimer’s
disease
(AD).
activity
regulated
at
multiple
steps,
synthesis,
posttranslational
modification,
secretion,
oligomerization,
proteolytic
processing,
interactions
with
extracellular
molecules.
Moreover,
differential
use
two
canonical
receptors
presence
non-canonical
co-receptors
add
to
functional
diversity
Reelin.
In
this
review,
I
summarize
findings
on
molecular
mechanisms
activity.
also
discuss
possible
strategies
enhance
Reelin’s
function.
A
complete
understanding
regulatory
central
nervous
system
could
help
ameliorate
disorders.
Язык: Английский
Alleviated Neuroinflammation and Increased Neuritogenesis by Palmitic Acid from Cissus quadrangularis
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 6, 2025
Язык: Английский
Antioxidant-Effective Quercetin Through Modulation of Brain Interleukin-13 Mitigates Autistic-Like Behaviors in the Propionic Acid-Induced Autism Model in Rats
Journal of Neuroimmune Pharmacology,
Год журнала:
2025,
Номер
20(1)
Опубликована: Апрель 12, 2025
Язык: Английский
Do specific myelin autoantibodies and increased cerebral dopamine neurotrophic factor in the context of inflammation predict the diagnosis of attention deficit hyperactivity disorder in medication-free children?
Brain Behavior and Immunity,
Год журнала:
2024,
Номер
124, С. 125 - 136
Опубликована: Ноя. 29, 2024
Язык: Английский
Integrating epigenetic modification and stem cell therapy strategies: A novel approach for advancing Alzheimer's disease treatment - A literature review.
PubMed,
Год журнала:
2024,
Номер
4(3), С. e935 - e935
Опубликована: Дек. 1, 2024
Alzheimer's
disease
(AD)
is
the
most
frequent
form
of
dementia
and
represents
an
increasing
global
burden,
particularly
in
countries
like
Indonesia,
where
population
has
begun
to
age
significantly.
Current
medications,
including
cholinesterase
inhibitors
NMDA
receptor
antagonists,
have
modest
effects
on
clinical
symptoms
early
middle
stages,
but
there
no
curative
treatment
available
so
far
despite
progress.
Activating
or
repressing
epigenetic
modifications,
DNA
methylation,
histone
modification
microRNA
regulation,
appears
play
important
role
AD
development.
These
alterations
further
enact
transcriptional
changes
relevant
signature
pathologies
amyloid-β
deposition,
tau
protein
malfunctioning,
neuroinflammation,
neuronal
death.
Here,
we
discuss
feasibility
targeting
these
as
a
new
strategy
due
reversibility
epigenetics
their
ability
correct
faulty
gene
expression.
We
also
review
combined
promise
stem
cell
therapies
modulation
neurodegeneration,
inflammation
cognitive
decline.
This
approach
may
provide
multifaceted
slow
progression,
replace
lost
neurons,
restore
neural
function.
Despite
challenges,
ethical,
financial,
methodological
barriers,
ongoing
research
therapy
holds
for
pioneering
AD.
Язык: Английский