Decreasing Trend of Gastroschisis Prevalence in the United States from 2014 through 2022: Is Attributed to Declining Birth Rates in Young, High-Risk Gravidae

European Journal of Obstetrics & Gynecology and Reproductive Biology X, Год журнала: 2025, Номер 25, С. 100374 - 100374

Опубликована: Фев. 12, 2025

To investigate the prevalence trend of gastroschisis in United States between 2014 and 2022. A cross-sectional retrospective analysis Centers for live births Pregnancies neonatal singleton with documented isolated were included. Neonates other major congenital anomalies known chromosomal abnormalities excluded. Prevalence per 10,000 along 95 % confidence intervals was estimated. Among 32,088,301 births, 6804 cases identified (Point prevalence: 2 births). significant decline observed, decreasing from 2.86 2014-1.55 2022 (P < 0.001). The risk significantly higher teen nulliparous gravidae, prepregnancy tobacco use, among socially vulnerable populations (underweight, 12th-grade education, Medicaid, non-Hispanic Indigenous Americans). drop to 2022, compared non-gastroschisis is more maternal age 20 years, nulliparous, BMI 18.5, smokers prior pregnancy than overall population = 0.02, 0.0008, <0.0001, 0.01 respectively). All associated factors had a 0.001), which may influence gastroschisis. There no perceived considerable impact COVID-19 pandemic on trends. study highlights notable mostly attributable declining birth rate highest at-risk strata, suggesting recent increases rates these gravidae reverse disease prevalence. These findings support need ongoing further research understand effective means sustaining this trend.

Язык: Английский

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Does COVID-19 Infection during Pregnancy Increase the Appearance of Congenital Gastrointestinal Malformations in Neonates?

Biomedicines, Год журнала: 2023, Номер 11(12), С. 3105 - 3105

Опубликована: Ноя. 21, 2023

COVID-19 was an infection that capable of bringing the entire world to a standstill position within period days months. Despite advancements in medical sector, contagion difficult control and costed lives millions people worldwide. Many short- long-term effects are witnessed even date contracted disease. Pregnant females had suffer not only devastating virus, but also psycho-social impact lockdown. The during pregnancy causing decreased antenatal care or hypoxemic episodes due severe respiratory distress whether it could lead appearance congenital gastrointestinal malformation neonates is still unclear. aim our study analyze if increase incidence gastric malformations born from these women.We sifted files all admitted into hospital between January 2022 December 2022, based on inclusion exclusion criteria, we included cases having pandemic. We performed single-center, retrospective, observational descriptive study. further divided patients anatomical location malformation. took down details evolution mother SARS-CoV-2 pregnancy. Details regarding Apgar score, intensive admission, sex, nutrition were key findings studied.A total 47 found have digestive anomalies, among which, locations, number at level esophagus 15, while 16 occurred pylorus; 12 duodenum, four rectum. Out neonates, 38.3% 61.7% males. A 58% preemies, which 9% intra-uterine growth retardation (IUGR), 42% full-term newborns, 4% (IUGR). 45% births primiparous pregnancies 55% multiparous females. 14 mothers tested positive for course (p-value = 0.23); many mild symptoms tested.COVID-19 can affect wellbeing pregnant female their fetus. Larger studies help gain extensive knowledge as has potential result anomalies children mothers. In study, few infants with this pathology be Hence, conclude exclude direct correlation malformations.

Язык: Английский

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Increased risk of fetal left–right asymmetry disorders associated with maternal SARS-CoV-2 infection during the first trimester

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 19, 2024

Abstract Our center has observed a substantial increase in the detection rate of fetal left–right(LR) asymmetry disorders between March and May 2023. This finding raised concerns because these pregnant women experienced peak outbreak SARS-CoV-2 China during their first trimester. To explore relationship maternal infection LR disorders. A retrospective collection clinical ultrasound data diagnosed as was conducted from January 2018 to December The case–control study involved fetuses with normal 1:1 ratio. We evaluated compared findings without infection. Student t -test utilized compare continuous variables, while chi-squared test employed for univariable analyses. incidence 2023 follows: 0.17‰, 0.63‰, 0.61‰, 0.57‰, 0.59‰, 3.24‰, respectively. total 30 were included. found that (96.67% vs 3.33%, P = .026) trimester (96.55% 3.45%, .008) identified risk factors. odds ratio values 10.545 (95% CI 1.227, 90.662) 13.067 1.467, 116.419) In cases trimester, majority infections (88.1%, 37/42) occurred 5 6 weeks gestation. 43.7% (66/151) disorder had associated malformations, 90.9% (60/66) exhibited cardiac malformations. significantly increases disorders, particularly when occurs gestation weeks. most common malformation is heart malformation.

Язык: Английский

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The Legacy of the COVID-19 Pandemic: Impact on Infant and Maternal and Health from an Appalachian Academic Medical Center

Опубликована: Июнь 17, 2024

The COVID-19 pandemic period, from 2020 - 2022 had a significant impact on maternal infant health with mothers impacted more than their infants. We questioned whether there have been any lingering effects the pandemic. examined intermediate and long-term of neonatal outcomes before, during after period. reviewed mother-infant pairs three epochs: 1) pre-COVID-19 2) 3) post-pandemic Case Mix Index (CMI) for neonates all 3 epochs were detailed. Post-pandemic we noted rising trend LGA infants (10%), an increase in SGA (13%). For women 2023 hypertension, preeclampsia, diabetes, higher BMI pre- There also congenital anomalies (9%), CMI increased Well maternal-infant continues to be affected. women, hypertension diabetes pregnancy is concerning. infants, being or may consequences. compared pre-pandemic era area that needs ongoing review.

Язык: Английский

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The Legacy of the COVID-19 Pandemic: Impact on Infant and Maternal and Health from an Appalachian Academic Medical Center

Children, Год журнала: 2024, Номер 11(8), С. 924 - 924

Опубликована: Июль 30, 2024

The COVID-19 pandemic period from 2020 to 2022 had a significant impact on maternal infant health with mothers impacted more than their infants. We questioned whether there have been any lingering effects the pandemic.

Язык: Английский

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Importance of Prenatal Diagnosis of Ileal Atresia in Gestational Diabetes Cases

American Journal of Case Reports, Год журнала: 2024, Номер 25

Опубликована: Март 25, 2024

Background:Maldevelopment of the fetal bowel can result in rare condition intestinal atresia, which results congenital obstruction.This report describes a case prenatal diagnosis ileal atresia at 22 weeks' gestation. Case Report:Here, we present 24-year old woman who was weeks into her first pregnancy when she underwent routine ultrasound.She diagnosed with gestational diabetes mellitus.Her body mass index normal and had weight gain.The ultrasonographic examination performed revealed hyperechoic small dilatation bowel.The couple counselled for possible its postnatal implications.At 33 gestation, polyhydramnios appeared, distension much more pronounced, debris lumen (succus-entericus).After birth, surgery concluded patient type II surgically treated. Conclusions:This has highlighted importance antenatal ultrasound detecting abnormalities, shown that conditions such as be accurately successfully managed.Surgical correction, if implemented promptly after stabilizing general condition, have relatively good prognosis.Coexisting mellitus are occurrences, make each even difficult to treat.

Язык: Английский

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COVID-19 pandemic waves and risk of congenital anomalies in the State of Sao Paulo: a population-based cohort study.

Authorea (Authorea), Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

Objectives To assess how the COVID outbreak in Brazil might have impacted birth defects State of São Paulo. Design Population-based cohort study. Setting The Paulo, Brazil. Population Births between 2017 and 2022. Methods Exposure was determined by midpoint first trimester. We used a generalized linear model with Poisson distribution log link, clustered robust standard errors. Municipality for clustering. Main Outcome Measures Relative Risk (RR) any congenital anomaly per each anatomical site. Results There were 2,961,741 cases analysis. RR anomalies 0.97 wave (95% CI: 0.95-1.00, p = 0.029) due to decrease respiratory, genitourinary central nervous system defects, pattern previously associated fever-induced anomalies. During third wave, there an 1.08 1.04-1.13, < 0.001), increase cleft lip palate, digestive circulatory just as severe food insecurity rose. No change risk identified during second when both vaccines introduced sales ivermectin hydroxychloroquine spiked. Conclusions COVID-19 differently wave. Considering concurrent conditions provide insight into underlying causes this phenomenon. true burden pregnant individuals supply chain disruption, which is also threatened climate change, not yet be fully recognized.

Язык: Английский

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COVID-19 in pregnancy: Perinatal outcomes and complications

World Journal of Virology, Год журнала: 2024, Номер 13(4)

Опубликована: Окт. 18, 2024

BACKGROUND The risk of severe coronavirus disease 2019 (COVID-19) in pregnant women is elevated. AIM To examine the outcomes with COVID-19 and report perinatal complications, while providing a brief review current literature. METHODS study included presenting from April 2020 to February 2022 emergency department (ED) tertiary hospital. We retrospectively recorded maternal files, including patient epidemiological clinical characteristics, laboratory values, outcomes, treatment modalities associations were explored. RESULTS Among 60 women, 25% required hospitalization, all whom symptomatic. Preterm delivery occurred 30% cases. Ten percent neonates admission neonatal intensive care unit, 5% classified as small for their gestational age. All mothers survived pregnancy, 6.6% requiring invasive mechanical ventilation. rates did not differ between hospitalized non-hospitalized women; composite unfavorable stillbirth, age, or unit (ICU) admission, significantly increase cases (P = 0.09). odds hospitalization increased 2.3-fold each day delayed ED presentation [adj. OR (95%CI: 1.46-3.624), P < 0.001]. Comorbidity status was an independent predictor albeit marginal significance 16.13 1.021-255.146), 0.048]. No predictors adverse fetal outcome (composite) identified, eventual failed reach statistical by slight margin 0.054). CONCLUSION Delayed comorbidities odds. This highlights importance continuous specific guidance managing patients, timely appropriate interventions minimize morbidity mortality.

Язык: Английский

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Failure to thrive in infant secondary to congenital colonic stenosis: a case report

Journal of Surgical Case Reports, Год журнала: 2024, Номер 2024(12)

Опубликована: Дек. 1, 2024

Congenital colonic stenosis (CCS) is a rare cause of intestinal obstruction, most commonly presenting in the neonatal period. We present case delayed CCS and describe diagnostic challenges experienced. A 16-week-old female patient presented with persistent failure to thrive associated signs obstruction. Prior encounters included investigation for pyloric stenosis, gastrointestinal pathogens, acid reflux, cow milk allergy, no little improvement symptoms. Abdominal imaging showed bowel dilation possible obstruction while excluding malrotation. Exploratory laparotomy revealed abrupt reduction caliber mid/distal transverse colon extreme luminal narrowing, consistent stenosis. Extended right hemicolectomy anastomosis resulted returned function appropriate weight gain follow-up. Though rare, should be considered cases partial or subacute throughout first year life. Inconclusive clinical results may support exploratory after differential diagnoses.

Язык: Английский

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