Immunological testing for female infertility: a modern view on the problem DOI Creative Commons

A. V. Konkina,

L. A. Blikyan,

D. E. Aleynikova

и другие.

Obstetrics Gynecology and Reproduction, Год журнала: 2024, Номер 18(4), С. 547 - 562

Опубликована: Июль 24, 2024

Introduction. According to various estimates, in Russia 10 20 % of people reproductive age are infertile. Changes the immune system play a key role etiology and treatment infertility forms. The active introduction immunological testing into clinical practice can potentially improve results diagnostics treatment. Aim: analyze current literature data on female infertility, as well assess its potential Materials Methods. There was conducted search for publications electronic databases PubMed eLibrary by using following keywords their combinations: "infertility", "immunology", "immune system", "immunological testing", "diagnostics", "treatment". articles were evaluated accordance with PRISMA recommendations. Ultimately, 88 included review. Results. Testing antiphospholipid antibodies (APA) may be useful women undergoing assisted technology (ART) therapy, these increase risk pregnancy complications thrombotic risks associated ovarian stimulation, but studies assessing AFA effect vitro fertilization (IVF) outcomes have ambiguous results. presence antithyroid (ATA) so assessment is indeed important determine tactics. It has been suggested that antinuclear (ANA) affect function disrupting trophoblast cell development interfering RNA transcription, which lead lowered success. Studies shown patients positive ANA lower incidence higher rate miscarriages after IVF procedure. human herpes virus type 6 (HHV-6) affects fertility often cause spontaneous termination pregnancy. B-cell lymphoma protein (BCL-6) serve an prognostic biomarker identify individuals endometriosis related disorders, including idiopathic infertility. Evaluation endometrial decidualization tool readiness implantation provide opportunities targeted therapeutic interventions. issue NK-cells screening remains controversial due difficulties standardizing Conclusion. To date, there limited number reliable tests With exception RPL, thyroid-stimulating hormone (TSH) anti-thyroperoxidase (TPOAb) therapy types technologies, remaining scant justify routine use practice. major limitations existing coupled small patient sample, heterogeneity inclusion criteria, groups research methods.

Язык: Английский

Immunological testing for female infertility: a modern view on the problem DOI Creative Commons

A. V. Konkina,

L. A. Blikyan,

D. E. Aleynikova

и другие.

Obstetrics Gynecology and Reproduction, Год журнала: 2024, Номер 18(4), С. 547 - 562

Опубликована: Июль 24, 2024

Introduction. According to various estimates, in Russia 10 20 % of people reproductive age are infertile. Changes the immune system play a key role etiology and treatment infertility forms. The active introduction immunological testing into clinical practice can potentially improve results diagnostics treatment. Aim: analyze current literature data on female infertility, as well assess its potential Materials Methods. There was conducted search for publications electronic databases PubMed eLibrary by using following keywords their combinations: "infertility", "immunology", "immune system", "immunological testing", "diagnostics", "treatment". articles were evaluated accordance with PRISMA recommendations. Ultimately, 88 included review. Results. Testing antiphospholipid antibodies (APA) may be useful women undergoing assisted technology (ART) therapy, these increase risk pregnancy complications thrombotic risks associated ovarian stimulation, but studies assessing AFA effect vitro fertilization (IVF) outcomes have ambiguous results. presence antithyroid (ATA) so assessment is indeed important determine tactics. It has been suggested that antinuclear (ANA) affect function disrupting trophoblast cell development interfering RNA transcription, which lead lowered success. Studies shown patients positive ANA lower incidence higher rate miscarriages after IVF procedure. human herpes virus type 6 (HHV-6) affects fertility often cause spontaneous termination pregnancy. B-cell lymphoma protein (BCL-6) serve an prognostic biomarker identify individuals endometriosis related disorders, including idiopathic infertility. Evaluation endometrial decidualization tool readiness implantation provide opportunities targeted therapeutic interventions. issue NK-cells screening remains controversial due difficulties standardizing Conclusion. To date, there limited number reliable tests With exception RPL, thyroid-stimulating hormone (TSH) anti-thyroperoxidase (TPOAb) therapy types technologies, remaining scant justify routine use practice. major limitations existing coupled small patient sample, heterogeneity inclusion criteria, groups research methods.

Язык: Английский

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