Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study

Oncology Letters, Год журнала: 2025, Номер 29(4)

Опубликована: Фев. 7, 2025

Malignant melanoma, a highly malignant tumor predominantly found on the skin surface, has exhibited an alarming rise in both incidence and mortality rates annually since 2012. Despite its relatively low occurrence among malignancies, rate of melanoma remains disproportionately high. The prognosis relies heavily early stage detection, with significant disparity survival between I IV patients. Studies exploring insulin resistance (IR) as potential risk factor for are scarce. present study therefore investigated association triglyceride glucose (TyG) index, indicator IR, incidence. Retrospective data from patients diagnosed at First Affiliated Hospital Nanjing Medical University (Nanjing, China) January 2019 2024 were collected. Basic information, including age, sex body mass hematological test results, such those fasting triglycerides blood glucose, analyzed. Logistic regression analysis receiver operating characteristic (ROC) curve employed to explore TyG index. A total 403 participants, 272 melanomas 131 nevi, included study. group significantly higher levels index compared control (P<0.001). Univariate multivariable logistic analyses revealed independent (OR, 6.33; 95% CI, 3.56‑11.27; P<0.001). Incidence increased across tertiles ROC identified clinically acceptable predictive cutoff point provides evidence that is melanoma. findings underscore utility biomarker diagnosing suggest new avenues treatment strategies.

Язык: Английский

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Spectrum of presentation of intraocular metastases from cutaneous melanoma in the era of immunotherapy and targeted therapies

Eye, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Язык: Английский

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Cutaneous melanoma

Nature Reviews Disease Primers, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 3, 2025

Язык: Английский

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Correspondence

Deutsches Ärzteblatt international, Год журнала: 2024, Номер unknown

Опубликована: Июль 17, 2024

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Correspondence

Deutsches Ärzteblatt international, Год журнала: 2024, Номер unknown

Опубликована: Июль 17, 2024

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Trends in incidence, mortality, and survival of cutaneous malignant melanoma over three decades: a population-based study in Southern Spain

Clinical and Experimental Dermatology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Abstract Background Cutaneous malignant melanoma (CMM) represents a global public health problem. Epidemiological studies about CMM trends tend to focus on single indicators or lack information tumour characteristics that can help gain more thorough understanding of epidemiology. Objectives To fill this gap, we studied in incidence, mortality and survival over three decades considered sex, age characteristics. Methods Data were obtained for all patients with new diagnosis during 1985–2017 from the population-based cancer registry Granada (Southern Spain) deaths owing Ministry Health Spanish government. Incidence, estimates according group, anatomical site, histological type, Breslow index Clark level. Observed net calculated 1, 3 5 years using Kaplan–Meier Pohar–Perme methods, respectively. Log-linear jointpoint regression was used assess temporal age-standardized rates incidence mortality. Results Between 1985 2017, 2446 aged ≥ 15 newly diagnosed CMM. There significant increase both males females (annual percentage change 4.4% 3.7%, respectively), mainly superficial spreading nodular melanomas, pronounced among those &lt; 1 mm index. Mortality increased, driven by increases individuals 65 old. Nodular had worst prognosis, 5-year 62.7% period 2008–2017 compared &gt; 90% other subtypes. Overall improved 78.3% 1985–1997 88.6% 2008–2017, clear trend Conclusions The early stages Southern Spain has increased recent decades. This been accompanied noticeable improvements survival, especially younger groups, suggesting potential effectiveness prevention strategies treatment regimens.

Язык: Английский

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Novel Approaches to 3D Skin Cancer Models Usability in Research

Interdisciplinary cancer research, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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Impact of Patient’s Age and Physician’s Professional Background on the Number Needed to Treat in Malignant Melanoma Detection

Cancers, Год журнала: 2024, Номер 16(23), С. 4014 - 4014

Опубликована: Ноя. 29, 2024

With regard to excision of pigmented lesions for detection malignant melanoma (MM), the number needed treat (NNT) describes melanocytic nevi that need be biopsied/excised detect one MM. The aim should a low NNT.

Язык: Английский

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