lncRNA EGOT Is the Marker of HPV Infection and a Prognostic Factor for HNSCC Patients

Biomedicines, Год журнала: 2025, Номер 13(4), С. 798 - 798

Опубликована: Март 26, 2025

Background: High-risk human papillomavirus (HPV) contributes to oropharyngeal cancers through mechanisms involving the deregulation of host cell functions by oncoproteins E6 and E7. Changes in epigenome, particularly long non-coding RNAs (lncRNAs), are crucial for understanding HPV-related carcinogenesis. Methods: This study aimed analyze expression levels lncRNAs head neck squamous carcinoma (HNSCC) determine their biological clinical significance, addressing current gap clinically validated biomarkers early screening therapeutic interventions. Results: The highlights significant overexpression EGOT gene HPV-positive HNSCC samples, suggesting its potential as a marker distinguish between HPV-negative cases. Furthermore, high correlates with better overall survival (OS) indicates possible resistance therapy, making it valuable prognostic factor. Conclusions: These findings underscore incorporating analysis practice improved patient stratification treatment outcomes HNSCC.

Язык: Английский

Molecular Mechanisms in the Carcinogenesis of Oral Squamous Cell Carcinoma: A Literature Review

Biomolecules, Год журнала: 2025, Номер 15(5), С. 621 - 621

Опубликована: Апрель 25, 2025

The tumor microenvironment (TME) plays a crucial role in the development, progression, and metastasis of oral squamous cell carcinoma (OSCC). TME comprises various cellular acellular components, including immune cells, stromal cytokines, extracellular matrix, microbiome, all which dynamically interact with cells to influence their behavior. Immunosuppression is key feature OSCC TME, regulatory T (Tregs), myeloid-derived suppressor (MDSCs), tumor-associated macrophages (TAMs) contributing an environment that allows evade surveillance supports angiogenesis. microbiome also pivotal pathogenesis, as dysbiosis, or imbalances microbiota, can lead chronic inflammation, promotes carcinogenesis through production pro-inflammatory cytokines reactive oxygen species (ROS). Pathogens like Porphyromonas gingivalis Fusobacterium nucleatum have, hence, been implicated OSCC-driven they induce activate oncogenic pathways, modulate responses. In this review, we discuss how interplay between immunosuppression microbiome-driven inflammation creates tumor-promoting OSCC, leading treatment resistance poor patient outcomes, explore potential therapeutic implication better understanding etiology molecular changes.

Язык: Английский

Orthotopic model of tongue cancer for the study of head and neck squamous cell carcinoma in mice

Methods in cell biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский