Medical academic journal,
Год журнала:
2024,
Номер
23(3), С. 41 - 53
Опубликована: Март 29, 2024
BACKGROUND:
Multiple
sclerosis
is
a
chronic
neurodegenerative
autoimmune
disease
characterized
by
the
presence
of
foci
inflammation
and
demyelination
in
central
nervous
system.
The
initiation
pathological
processes
multiple
caused
complex
interaction
genetic
factors,
unfavorable
environmental
factors
epigenetic
influences.
Progressive
neurological
symptoms
axonal
conduction
disorders,
death
neurodestruction
lead
to
significant
decreased
patients’
quality
life
disability.
search
for
new
markers
improve
diagnostic
therapeutic
methods,
including
taking
into
account
background
interactions,
an
urgent
task.
AIM:
work
was
aimed
study
changes
DNMT1
mRNA
expression
patients
with
different
duration,
analyze
methylation
promoter,
compare
level
homocysteine
content
blood,
polymorphic
variants
genes
coding
key
folate
cycle
enzymes.
MATERIALS
AND
METHODS:
peripheral
mononuclear
blood
cells
assessed
reversed
transcription
followed
polymerase
chain
reaction.
Fluorescent
reaction
methyl-sensitive
analysis
high-resolution
melting
curves
used
promoter.
determined
chemiluminescence
immunoassay.
real-time
genotyping
polymorphism
genes;
fluorescent
probes
LNA
modifications
were
discriminate
alleles.
RESULTS:
It
has
been
shown
that
patients,
those
at
onset
disease,
significantly
lower
than
control
group.
No
relationship
found
between
decrease
promoter
methylation.
Strong
positive
combined
effects
genotypes
MTR
A2756G
MTHFR
C677T
on
have
shown.
These
findings
suggest
genetically
features
metabolism
may
contribute
disruption
regulation
sclerosis.
CONCLUSIONS:
obtained
results
indicate
promise
research
identifying
causing
Studying
mechanisms
contribution
pathogenesis
could
be
one
possible
ways
approaches.
Biomolecules,
Год журнала:
2023,
Номер
13(12), С. 1759 - 1759
Опубликована: Дек. 7, 2023
Recent
advancements
in
the
understanding
of
how
sperm
develop
into
offspring
have
shown
complex
interactions
between
environmental
influences
and
genetic
factors.
The
past
decade,
marked
by
a
research
surge,
has
not
only
highlighted
profound
impact
paternal
contributions
on
fertility
reproductive
outcomes
but
also
revolutionized
our
comprehension
unveiling
parental
factors
sculpt
traits
successive
generations
through
mechanisms
that
extend
beyond
traditional
inheritance
patterns.
Studies
are
more
susceptible
to
factors,
especially
during
critical
phases
growth.
While
these
broadly
detrimental
health,
their
effects
acute
periods.
Moving
immutable
nature
genome,
epigenetic
profile
cells
emerges
as
dynamic
architecture.
This
flexibility
renders
it
disruptions.
primary
objective
this
review
is
shed
light
diverse
processes
which
agents
affect
male
capacity.
Additionally,
explores
consequences
interactions,
demonstrating
can
reverberate
offspring.
It
encompasses
direct
changes
well
broad
spectrum
adaptations.
By
consolidating
current
empirically
supported
research,
offers
an
exhaustive
perspective
interwoven
trajectories
environment,
genetics,
epigenetics
elaborate
transition
from
World Journal of Clinical Pediatrics,
Год журнала:
2024,
Номер
13(3)
Опубликована: Авг. 29, 2024
Autism
spectrum
disorder
(ASD)
is
a
complex
neurodevelopmental
condition
characterized
by
heterogeneous
symptoms
and
genetic
underpinnings.
Recent
advancements
in
epigenetic
research
have
provided
insights
into
the
intricate
mechanisms
contributing
to
ASD,
influencing
both
diagnosis
therapeutic
strategies.
Journal of Population Therapeutics and Clinical Pharmacology,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Multiple
sclerosis
(MS)
is
a
chronic
inflammatory
disease
affecting
the
central
nervous
system
(CNS),
characterized
by
immune-mediated
assaults
on
myelin
sheath.
This
autoimmune
disorder
primarily
impacts
young
individuals
and
can
result
in
permanent
axonal
degeneration.
The
manifestations
of
MS
vary,
encompassing
relapsing-remitting
MS,
primary-progressive
secondary-progressive
MS.
etiology
stems
from
an
immune
dysfunction,
culminating
obliteration
healthy
cells.
Therapeutic
approaches
for
are
geared
towards
averting
exacerbations
protracted
functional
deterioration,
with
diverse
FDA-endorsed
drugs
stratified
according
to
their
efficacy
relapse
mitigation.
precise
origin
remains
elusive;
nonetheless,
immunomodulated
genetic
predisposition
environmental
factors
postulated
exert
considerable
influence
its
onset.
Frontiers in Genetics,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 4, 2023
Black
and
Hispanic
American
patients
frequently
develop
earlier
onset
of
multiple
sclerosis
(MS)
a
more
severe
disease
course
that
can
be
resistant
to
modifying
treatments.
The
objectives
were
identify
differential
methylation
genomic
DNA
(gDNA)
associated
with
susceptibility
treatment
responses
in
cohort
MS
from
underrepresented
minority
populations.
Patients
controls
non-inflammatory
neurologic
conditions
consented
enrolled
under
an
IRB-approved
protocol.
Approximately
64%
donors
identified
as
or
African
30%
White,
Hispanic-Latino.
Infinium
MethylationEPIC
bead
arrays
utilized
measure
epigenome-wide
gDNA
whole
blood.
Data
analyzed
the
presence
absence
adjustments
for
unknown
covariates
dataset,
some
which
corresponded
Global
patterns
strongest
those
probes
showed
relative
demethylation
loci
lower
M
values.
Pathway
analysis
revealed
unexpected
associations
shigellosis
amoebiasis.
Enrichment
over-representation
enhancer
regions
under-representation
promoters.
In
included
treatments,
10
differentially
methylated
(DMR's)
FDR
<1E-77.
Five
these
genes
(ARID5B,
BAZ2B,
RABGAP1,
SFRP2,
WBP1L)
are
cancer
risk
cellular
differentiation
have
not
been
previously
studies.
Hierarchical
cluster
multi-dimensional
scaling
at
147
within
DMR's
was
sufficient
differentiate
controls.
corrections
treated
dimethyl
fumarate
immune
regulatory
pathways
regulate
cytokine
chemokine
signaling,
axon
guidance,
adherens
junctions.
These
results
demonstrate
possible
gastrointestinal
pathogens
regulation
our
patient
cohort.
This
work
further
suggests
analyses
performed
therapies.
Because
their
high
representation
cohort,
may
specific
relevance
Americans.
