Missed Adjuvant Therapy in Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma DOI Creative Commons
Lily Huang, Aman M. Patel, Afash Haleem

и другие.

The Laryngoscope, Год журнала: 2024, Номер 135(2), С. 729 - 740

Опубликована: Окт. 8, 2024

Objective Investigate missed adjuvant therapy and associated disparities in overall survival (OS) for human papillomavirus‐associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC). Methods The 2010–2017 National Cancer Database was queried patients with surgically resected HPV+ OPSCC. Indications radiotherapy (aRT) included pT3‐4 classification, pN2‐3 lymphovascular invasion, pathologic extranodal extension (pENE), and/or positive surgical margins (PSM). Indication(s) chemoradiotherapy (aCRT) pENE PSM. Multivariable logistic Cox regression models were implemented. Results Of 5297 satisfying inclusion criteria, 4288 had indication(s) aRT; 775 did not receive any considered as missing aRT. A total of 2234 aCRT. these, 1383 (61.9%) received aCRT, 555 (24.8%) aRT alone having 296 (13.2%) therapy. Missed aCRT each age, treatment facility type, pN margin status ( p < 0.015). Among alone, OS those receiving no therapy, 90.0%, 94.8%, 93.4%, respectively = 0.080). similar (89.0% vs. 86.6%, 0.357) which superior to (74.9%, 0.001). These patterns persisted on multivariable regression. Conclusion OPSCC aRT, worse OS. For Level Evidence 3 Laryngoscope , 135:729–740, 2025

Язык: Английский

Hypoxia-Directed Treatment of Human Papillomavirus–Related Oropharyngeal Carcinoma DOI
Nancy Y. Lee, Eric J. Sherman, Heiko Schöder

и другие.

Journal of Clinical Oncology, Год журнала: 2024, Номер 42(8), С. 940 - 950

Опубликована: Янв. 19, 2024

PURPOSE Standard curative-intent chemoradiotherapy for human papillomavirus (HPV)–related oropharyngeal carcinoma results in significant toxicity. Since hypoxic tumors are radioresistant, we posited that the aerobic state of a tumor could identify patients eligible de-escalation while maintaining treatment efficacy. METHODS We enrolled with HPV-related to receive de-escalated definitive phase II study (ClinicalTrials.gov identifier: NCT03323463 ). Patients first underwent surgical removal disease at their primary site, but not gross neck. A baseline 18 F-fluoromisonidazole positron emission tomography scan was used measure hypoxia and repeated 1-2 weeks intratreatment. nonhypoxic received 30 Gy (3 weeks) chemotherapy, whereas those standard 70 (7 weeks). The objective achieving 2-year locoregional control (LRC) 95% 7% noninferiority margin. RESULTS One hundred fifty-eight T0-2/N1-N2c were enrolled, which 152 analyses. Of these, 128 met criteria 24 Gy. LRC 94.7% (95% CI, 89.8 97.7), meeting our objective. With median follow-up time 38.3 (range, 22.1-58.4) months, progression-free survival (PFS) overall (OS) rates 94% 100%, respectively, 30-Gy cohort. 70-Gy cohort had similar PFS OS 96% 96%, respectively. Acute grade 3-4 adverse events more common versus (58.3% v 32%; P = .02). Late only occurred cohort, 4.5% complained late dysphagia. CONCLUSION Tumor is promising approach direct dosing carcinomas preserved efficacy substantially reduced toxicity requires further investigation.

Язык: Английский

Процитировано

39
Recent update on the Development of HPV16 inhibitors for Cervical Cancer DOI
Muhammad Shoaib, Amina Tariq, Yanchen Liu

и другие.

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104703 - 104703

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Development of a Novel Anti-CD44 Variant 7/8 Monoclonal Antibody, C44Mab-34, for Multiple Applications against Oral Carcinomas DOI Creative Commons
Hiroyuki Suzuki,

Kazuki Ozawa,

Tomohiro Tanaka

и другие.

Biomedicines, Год журнала: 2023, Номер 11(4), С. 1099 - 1099

Опубликована: Апрель 5, 2023

Cluster of differentiation 44 (CD44) has been investigated as a cancer stem cell (CSC) marker it plays critical roles in tumor malignant progression. The splicing variants are overexpressed many carcinomas, especially squamous and play the promotion metastasis, acquisition CSC properties, resistance to treatments. Therefore, each CD44 variant (CD44v) function distribution carcinomas should be clarified for establishment novel diagnosis therapy. In this study, we immunized mouse with (CD44v3–10) ectodomain established various anti-CD44 monoclonal antibodies (mAbs). One clones (C44Mab-34; IgG1, kappa) recognized peptide that covers both 7- 8-encoded regions, indicating C44Mab-34 is specific mAb CD44v7/8. Moreover, reacted CD44v3–10-overexpressed Chinese hamster ovary-K1 (CHO) cells or oral carcinoma (OSCC) line (HSC-3) by flow cytometry. apparent KD CHO/CD44v3–10 HSC-3 was 1.4 × 10−9 3.2 M, respectively. could detect CD44v3–10 Western blotting stained formalin-fixed paraffin-embedded OSCC immunohistochemistry. These results indicate useful detecting CD44v7/8 applications expected application

Язык: Английский

Процитировано

14
Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma DOI Creative Commons

Junshang Ge,

Yi Meng,

Jiayue Guo

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 4, 2024

Язык: Английский

Процитировано

5
Virusplot: a web server for viral integration analysis and visualization DOI Creative Commons
Erqiang Hu, J. An, A. Gersten

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Фев. 19, 2025

The integration of viral DNA into the human genome is a critical event in pathogenesis various cancers. This process leads to genomic instability, disrupts cellular regulatory mechanisms, and activates oncogenes or inactivates tumor suppressor genes. Despite significant advancements sequencing technologies, there remains notable lack computational tools, particularly web-based applications, specifically designed for analysis visualization. To address this gap, we present virusPlot, web server with following functional modules: (i) automatic retrieval virus sequences their annotation; (ii) visualization locations read counts through graphical representation that links host sites, facilitating interpretation patterns; (iii) hotspots using Fisher's exact test; (iv) functions an interactive platform via shinyapp. VirusPlot efficiently processes visualizes data from viruses genomes, providing researchers intuitive user-friendly analytical tool simplifies complexity analysis.

Язык: Английский

Процитировано

0
HPV-driven cancer: from epidemiology to the HPV-driven tumor board proposal, everything you wanted to know but were afraid to ask DOI
Daniela Alterio,

Michał Gola,

Mattia Zaffaroni

и другие.

Clinical & Translational Oncology, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
2024 ASCO guidelines for the prevention and management of osteoradionecrosis in patients with head & neck cancer treated with radiation therapy DOI
Douglas E. Peterson, Noam Yarom, Charlotte Duch Lynggaard

и другие.

Current Opinion in Oncology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Purpose of review Osteoradionecrosis may often be prevented in context interprofessional healthcare that includes dental specialists prior to and following completion the patient's head neck radiation therapy. Important factors, however, compromise delivery guideline-concordant management osteoradionecrosis (ORN), including patient access this care. This is directed these related issues, order foster enhanced approaches for ORN management. Recent findings The centered 2024 Journal Clinical Oncology publication ‘Prevention Management Patients With Head Neck Cancer Treated Radiation Therapy: ISOO-MASCC-ASCO Guideline’, companion JCO Practice which clinical insights guideline are addressed. Key recent literature cited provide contemporary decision-making prevention early diagnosis treatment ORN. Although a relatively infrequent complication patients, can have profound financial impact when it occurs. Summary Interprofessional oncology care essential Future research needed enhance management, studies predicting risk development based on patient-centered factors.

Язык: Английский

Процитировано

0
Predictors of Radiation Resistance and Novel Radiation Sensitizers in Head and Neck Cancers: Advancing Radiotherapy Efficacy DOI
Aastha Sobti, Heath D. Skinner, Christopher Wilke

и другие.

Seminars in Radiation Oncology, Год журнала: 2025, Номер 35(2), С. 224 - 242

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

0
Managing Patients with Head and Neck Cancer and Advanced Age or Comorbidities DOI
James Price, Loren K. Mell

Seminars in Radiation Oncology, Год журнала: 2025, Номер 35(2), С. 197 - 206

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

0
A Bibliometric Analysis of HPV-Positive Oropharyngeal Squamous Cell Carcinoma from 2000 to 2023 DOI Creative Commons
Yingying Cui,

Wei Li,

Binbin Li

и другие.

Pathogens, Год журнала: 2025, Номер 14(3), С. 289 - 289

Опубликована: Март 15, 2025

Human-papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC) is a distinct disease characterized by unique clinical and molecular features compared to HPV-negative OPSCC. A comprehensive bibliometric analysis of HPV-positive OPSCC research was conducted in this study identify key trends, hotspots, emerging frontiers the field. Data were retrieved from Web Science Core Collection database. The distributions contributors, including countries, institutions, authors, journals, cooperative networks related OPSCC, analyzed visualized using VOSviewer 1.6.20, CiteSpace 6.3.R1, R package Bibliometrix 4.0.0. In addition, most influential publications high-frequency keywords identified discern topics total 3895 articles reviews on identified, involving 106 620 18949 authors. main contributors include USA (1908 publications), Johns Hopkins University (310 journal Head Neck (320 Erich M. Sturgis (94 publications). top three are “survival”, “radiotherapy”, “p16”. There has been steadily increasing interest over last 23 years. Current studies focus diagnosis, treatment strategies, prognosis, recurrence, surveillance. This highlights themes, offering insights for future directions.

Язык: Английский

Процитировано

0