Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Май 16, 2024
The
risk
of
developing
subsequent
breast
cancer
is
higher
in
women
diagnosed
with
benign
disease
(BBD)
but
these
studies
were
primarily
performed
non-Hispanic
white
populations.
Still,
estimates
have
been
used
to
inform
models
that
are
being
clinically
across
all
racial
and
ethnic
groups.
Given
the
high
mortality
rates
among
African
American
(AA)
women,
it
critical
study
BBD
this
population,
ensure
include
information
perform
adequately.
This
utilized
data
from
AA
who
underwent
biopsies
at
a
hospital
served
by
University
Pathology
Group
Detroit,
Michigan,
1998
2010.
Patients
followed
for
cancers
through
population-based
Metropolitan
Detroit
Cancer
Surveillance
System
(MDCSS).
lesion
scores
assigned
represent
severity
or
extent
lesions,
indicating
greater
number
distinct
types.
Of
3,461
eligible
cohort,
6.88%
(n=238)
subsequently
developed
cancer.
Examined
individually,
six
eleven
lesions
(apocrine
metaplasia,
ductal
hyperplasia,
lobular
intraductal
papilloma,
sclerosing
adenosis,
columnar
alterations
radial
scars)
significantly
associated
increased
after
adjustment
age
year
biopsy
further
considered
multiple
models.
For
every
different
type
lesion,
25%
(RR=1.25,
95%
CI:
1.10,
1.42)
proliferative
versus
non-proliferative
disease.
In
summary,
affirms
BBD,
particularly
those
lesions.
These
findings
implications
management
millions
affected
group
could
benefit
personalized
surveillance
reduction
strategies.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 22, 2024
Background
Cervical
cancer
remains
a
significant
gynecologic
malignancy
in
both
China
and
the
United
States,
posing
substantial
threat
to
women’s
lives
health
due
its
high
morbidity
mortality
rates.
Altered
energy
metabolism
dysregulated
mitochondrial
function
play
crucial
roles
development,
growth,
metastasis,
recurrence
of
malignant
tumors.
In
this
study,
we
aimed
predict
prognosis
assess
efficacy
anti-tumor
therapy
cervical
patients
based
on
differential
genes
associated
with
metabolism.
Methods
Transcriptomic
data
clinical
profiles
were
retrieved
from
TCGA
GEO
databases.
Differential
gene-related
cellular
pathways
identified
through
GO,
KEGG,
GSEA
analyses.
Prognostic
indices
constructed
using
LASSO
regression
analysis.
Immune
cell
infiltration
was
assessed
CIBERSORT
ssGSEA,
correlation
between
immune
checkpoint
inhibitor
examined.
Tumor
mutation
load
(TMB)
association
prognostic
analyzed
nucleotide
variant
database.
Patient
response
immunotherapy
sensitivity
antitumor
drugs
determined
TIDE
algorithm
oncoPredic
algorithm,
respectively.
Results
A
index
metabolism-related
developed
outcome
patients,
enabling
their
classification
into
two
distinct
subtypes.
The
emerged
as
an
independent
risk
factor
for
unfavorable
prognosis.
high-index
group
exhibited
significantly
worse
overall
prognosis,
along
elevated
tumor
burden
(TMB),
increased
infiltration,
lower
scores,
indicating
potential
benefit
immunotherapy.
Conversely,
low-index
demonstrated
agents,
specifically
multikinase
inhibitors.
Conclusion
aim
study
develop
metabolism,
which
could
be
used
patients’
prognoses.
When
combined
TMB
analyses,
offers
insights
landscape,
well
targeted
therapy.
Our
analysis
suggests
that
Iron-Sulfur
Cluster
Assembly
Enzyme
(ISCU)
gene
holds
promise
biomarker
International journal of engineering. Transactions C: Aspects,
Год журнала:
2023,
Номер
36(3), С. 505 - 512
Опубликована: Янв. 1, 2023
Brain
tumors
are
one
of
the
most
common
causes
death
that
have
been
widely
investigated
by
scholars
in
research
areas,
including
care
and
prevention.
Despite
various
empirical
studies
on
brain
tumor
segmentatin,
there
is
still
a
need
for
further
investigation.
This
fact
more
needed
automatic
methods
detection.
In
present
study,
new
method
improving
segmentation
accuracy
based
super-pixel
fast
primal
dual
(PD)
algorithms
has
proposed.
The
proposed
detects
tissue
Flair-MRI
imaging
BRATS2012
dataset.
primary
borders
using
algorithm,
improves
PD
Markov
random
field
optimization.
Then,
post-processing
processes
used
to
delete
white
areas.
Finally,
an
active
contour
algorithm
was
employed
display
area.
Different
experiments
were
carried
qualitative
quantitative
criteria
such
as
dice
similarity
measure,
F-measure
evaluation.
obtained
results
showed
efficiency
method,
sensitivity
86.59
88.57%
F1-Measure
86.37
obtained,
respectively.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Май 16, 2024
The
risk
of
developing
subsequent
breast
cancer
is
higher
in
women
diagnosed
with
benign
disease
(BBD)
but
these
studies
were
primarily
performed
non-Hispanic
white
populations.
Still,
estimates
have
been
used
to
inform
models
that
are
being
clinically
across
all
racial
and
ethnic
groups.
Given
the
high
mortality
rates
among
African
American
(AA)
women,
it
critical
study
BBD
this
population,
ensure
include
information
perform
adequately.
This
utilized
data
from
AA
who
underwent
biopsies
at
a
hospital
served
by
University
Pathology
Group
Detroit,
Michigan,
1998
2010.
Patients
followed
for
cancers
through
population-based
Metropolitan
Detroit
Cancer
Surveillance
System
(MDCSS).
lesion
scores
assigned
represent
severity
or
extent
lesions,
indicating
greater
number
distinct
types.
Of
3,461
eligible
cohort,
6.88%
(n=238)
subsequently
developed
cancer.
Examined
individually,
six
eleven
lesions
(apocrine
metaplasia,
ductal
hyperplasia,
lobular
intraductal
papilloma,
sclerosing
adenosis,
columnar
alterations
radial
scars)
significantly
associated
increased
after
adjustment
age
year
biopsy
further
considered
multiple
models.
For
every
different
type
lesion,
25%
(RR=1.25,
95%
CI:
1.10,
1.42)
proliferative
versus
non-proliferative
disease.
In
summary,
affirms
BBD,
particularly
those
lesions.
These
findings
implications
management
millions
affected
group
could
benefit
personalized
surveillance
reduction
strategies.
