Cancer statistics, 2025

CA A Cancer Journal for Clinicians, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

ABSTRACT Each year, the American Cancer Society estimates numbers of new cancer cases and deaths in United States compiles most recent data on population‐based occurrence outcomes using incidence collected by central registries (through 2021) mortality National Center for Health Statistics 2022). In 2025, 2,041,910 618,120 are projected to occur States. The rate continued decline through 2022, averting nearly 4.5 million since 1991 because smoking reductions, earlier detection some cancers, improved treatment. Yet alarming disparities persist; Native people bear highest mortality, including rates that two three times those White kidney, liver, stomach, cervical cancers. Similarly, Black have two‐fold higher than prostate, uterine corpus Overall has generally declined men but risen women, narrowing male‐to‐female ratio (RR) from a peak 1.6 (95% confidence interval, 1.57–1.61) 1992 1.1 1.12–1.12) 2021. However, women aged 50–64 years already surpassed (832.5 vs. 830.6 per 100,000), younger (younger 50 years) an 82% their male counterparts (141.1 77.4 up 51% 2002. Notably, lung among 65 2021 (15.7 15.4 100,000; RR, 0.98, p = 0.03). summary, continues decline, future gains threatened rampant racial inequalities growing burden disease middle‐aged young adults, especially women. Continued progress will require investment prevention access equitable treatment, individuals.

Язык: Английский

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Platinum–Iron Nanoparticles for Oxygen-Enhanced Sonodynamic Tumor Cell Suppression

Inorganics, Год журнала: 2024, Номер 12(12), С. 331 - 331

Опубликована: Дек. 18, 2024

A type of nanoparticle has been developed to simultaneously alleviate tumor hypoxia and enhance the effectiveness sonodynamic therapy aimed at improving cancer treatment outcomes. Small-sized iron–platinum nanoparticles were prepared using a thermal reduction method, their particle size crystal structure characterized. The ability these decompose hydrogen peroxide produce oxygen generate singlet under ultrasound irradiation was further tested. effect on inhibition proliferation MCF-7 cells hypoxic conditions also evaluated. effectively decomposed oxygen, reversing environment tumors. Additionally, they generated irradiation, which killed inhibited proliferation. This study successfully small-sized that can by decomposing excess in oxygen. Under inhibiting growth. demonstrated good safety are potentially valuable enhancing oxygen-enhanced therapy.

Язык: Английский

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Cancers attributed to Modifiable Factors in Norway 2016-2020

European Journal of Cancer, Год журнала: 2025, Номер 217, С. 115232 - 115232

Опубликована: Янв. 10, 2025

Highlights•33% of new cancer cases in Norway 2016-20 were attributed to 12 modifiable factors•Tobacco smoking causes the largest proportion preventable cases•Ultraviolet radiation and overweight obesity next important factors•Skin, lung, colon breast cancers have highest number casesAbstractBackgroundTargeting factors offers significant potential for primary prevention. For public health strategies, it is essential quantify contribution from each factor on a national level. We estimated incidence Norwegian population.MethodsNationally representative data (1990-2015) prevalence tobacco smoking, over-exposure ultraviolet (UVR), alcohol consumption, physical inactivity, obesity, intake processed red meat, fibre calcium, menopausal hormone therapy (MHT), human papilloma virus (HPV) infection insufficient breastfeeding collected surveys. Using these prevalences, risk estimates exposures, average annual rates 2016-2020, we population-attributable fractions (PAFs) numbers cases.ResultsOf 24,608 related our included factors, 12,12,250 (6,240 women 6,009 men) (41%) factors. Tobacco caused cases, 20% men 13% women. Sunburn indoor tanning 10% women, respectively, 4.5% cases. Cancers skin, female had cases.ConclusionOver third Based this study, efforts reduce UVR over-exposure, could be most effective prevention cancer.

Язык: Английский

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Once-Weekly Semaglutide in Adults With Alcohol Use Disorder

JAMA Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Importance Preclinical, observational, and pharmacoepidemiology evidence indicates that glucagon-like peptide 1 receptor agonists (GLP-1RAs) may reduce alcohol intake. Randomized trials are needed to determine the clinical significance of these findings. Objective To evaluate effects once-weekly subcutaneous semaglutide on consumption craving in adults with use disorder (AUD). Design, Setting, Participants This was a phase 2, double-blind, randomized, parallel-arm trial involving 9 weeks outpatient treatment. Enrollment occurred at an academic medical center US from September 2022 February 2024. Of 504 potential participants assessed, 48 non–treatment-seeking AUD were randomized. Intervention received (0.25 mg/week for 4 weeks, 0.5 1.0 mg week) or placebo weekly clinic visits. Main Outcomes Measures The primary outcome laboratory self-administration, measured pretreatment posttreatment (0.5 mg/week). Secondary exploratory outcomes, including prospective changes craving, assessed Results Forty-eight (34 [71%] female; mean [SD] age, 39.9 [10.6] years) Low-dose reduced amount consumed during self-administration task, medium large effect sizes grams (β, −0.48; 95% CI, −0.85 −0.11; P = .01) peak breath concentration −0.46; −0.87 −0.06; .03). Semaglutide treatment did not affect average drinks per calendar day number drinking days, but significantly −0.41; −0.73 −0.09; .04) −0.39; .01), also predicting greater reductions heavy over time relative 0.84; 0.71 0.99; .04). A significant treatment-by-time interaction indicated predicted cigarettes subsample individuals current cigarette −0.10; −0.16 −0.03; .005). Conclusions Relevance These findings provide initial low-dose can some justifying larger GLP-1RAs disorder. Trial Registration ClinicalTrials.gov Identifier: NCT05520775

Язык: Английский

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Global, Regional, and National Disease Burden and Prediction Analysis of Colorectal Cancer Attributable to Tobacco, Alcohol, and Obesity From 1990 to 2030

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Фев. 26, 2025

Colorectal cancer (CRC) ranks among the highest in incidence and mortality rates globally. A significant portion of cases deaths can be attributed to modifiable risk factors, with smoking, alcohol use, high body mass index (BMI) being three most prominent. However, impact these factors on across regions, genders, age groups remains insufficiently characterized. Utilizing data from Global Burden Disease (GBD) study 2019, restrictive cubic splines (RCS) quantile regression analyses are applied explore relationship between Socio-Demographic Index (SDI) ASMR or ASDR. Additionally, gender differences, changes different SDI levels, group trends BMI over 30-year period analyzed. The Bayesian age-period-cohort (BAPC) model is employed predict 2020 2030, aiming epidemiological sociodemographic transitions disease burden BMI. In number colorectal globally attributable as consumption, obesity increased 142,931, 52,495, 85,882 respectively, collectively accounting for approximately one-third all cancer-related deaths. Notably, there an upward trend early-onset associated factors. To reduce cancer, it recommended enhance health education, promote smoking cessation moderation, increase coverage participation screening, which crucial lowering rates. These findings vital development public policies intervention measures global burden. They provide guidance prevention worldwide.

Язык: Английский

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Traditional Chinese medicine in lung cancer treatment

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 26, 2025

Lung cancer remains a major global health challenge and one of the leading causes cancer-related deaths worldwide. Despite significant advancements in treatment, challenges such as drug resistance, side effects, metastasis recurrence continue to impact patient outcomes quality life. In response, there is growing interest complementary integrative approaches care. Traditional Chinese medicine (TCM), with its long history, abundant clinical experience, holistic perspective individualized approach, has garnered increasing attention for role lung prevention management. This review provides comprehensive overview advances TCM covering theoretical foundation, treatment principles, experiences evidence supporting efficacy. We also provide systematic summary preclinical mechanisms, through which impacts cancer, including induction cell death, reversal inhibition modulation immune responses. Additionally, future prospects are discussed, offering insights into expanded application integration modern address this challenging disease.

Язык: Английский

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Averted lung cancer deaths due to reductions in cigarette smoking in the United States, 1970–2022

CA A Cancer Journal for Clinicians, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Lung cancer mortality rates in the United States have declined steeply recent decades, largely because of substantial reductions smoking prevalence, as approximately 85% lung deaths are attributable to cigarette smoking. In this study, authors estimate number averted and corresponding person-years life gained during 1970-2022 a measure progress prevention through tobacco control. By using National Center for Health Statistics data (with national coverage), calculated expected each year, age, sex, race, age group based on death rate multiplied by population at risk that group. The were subtracting observed from Person-years estimated avoided premature average additional years person would lived if they had not died cancer. 3,856,240 (2,246,610 men, 1,609,630 women) averted, 76,275,550 (40,277,690 35,997,860 1970-2022, with an 19.8 (17.9 22.4 per death. accounted 51.4% declines overall was substantially greater men (60.1%) than women (42.7%). proportion 53.6% White (62.8% 44.6% 40.0% Black (44.4% 34.7% women). numbers highlight remarkable effect against reducing

Язык: Английский

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Causal associations between dietary factors with head and neck cancer: A two‐sample Mendelian randomization study

Laryngoscope Investigative Otolaryngology, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 7, 2025

Abstract Objective Although an association exists between dietary habits and head neck cancer (HNC), the direct cause‐and‐effect connection remains elusive. Our objective was to investigate causal associations factors likelihood of developing HNC. Methods Genome‐wide study (GWAS) summary statistics for were screened from UK Biobank, OncoArray Oral Cavity Oropharyngeal Cancer consortium, FinnGen biobank A two‐sample Mendelian randomization (MR) analysis utilized establish causality. The primary method inverse variance weighting (IVW). Results Clear evidence existed dried fruit intake HNC in both cohorts (OncoArray consortium: IVW OR = 0.183; 95% CI, 0.037–0.915; p .03864; FinnGen: 0.281; 0.115–0.688; .00547). In addition, fresh (IVW‐mre 0.066; 0.011–0.413; .00369), beef (IVW 15.094; 1.950–116.853; .00934), lamb/mutton intakes 5.799; 1.044–32.200; .0448) significantly associated with consortium cohort. Conclusions Dried may be a protective factor against red meat warrants careful interpretation. Additional studies are necessary explore potential mechanisms further evidence. Level evidence: III

Язык: Английский

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Habitual sleep duration, healthy eating, and digestive system cancer mortality

BMC Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 27, 2025

Abstract Background Lifestyle choices, such as dietary patterns and sleep duration, significantly impact the health of digestive system may influence risk mortality from cancer. Methods This study aimed to examine associations between habits, cancers. The analysis included 406,584 participants UK Biobank cohort (54.1% women; age range: 38–73 years), with duration classified short (≤ 6 h, 24.2%), normal (7–8 68.4%), long (≥ 9 7.4%). Healthy eating habits were defined a daily intake at least 25 g fibre, seven portions fruits vegetables, fewer than four servings meat per week. These factors combined into score ranging 0 (least healthy) 3 (healthiest). Cox proportional hazards regression analyses conducted, median follow-up period 12.6 years, ending on September 30, 2021. Results 3949 died cancer system. Both associated an increased (1.09 (1.01–1.18) 1.14 (1.03–1.27), respectively). Additionally, diet ≥ 1 was linked lower (0.72–0.91 (0.59–0.96)). Adjusting for smoking, type 2 diabetes, body mass index (BMI) status eliminated association mortality. healthy did not vary by duration. Conclusions Aberrant durations increase cancer, potentially through higher BMI, diabetes. However, aberrant do seem reduce protective effects pattern.

Язык: Английский

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Differences in Provider Beliefs and Delivery of the 5As for Cigarette and Non-Cigarette Tobacco Use Between Two Types of Healthcare Centers Serving Rural and/or Medically Underserved Areas of Texas, US

Healthcare, Год журнала: 2025, Номер 13(3), С. 338 - 338

Опубликована: Фев. 6, 2025

Background/Objectives: Rural populations in the US bear a disproportionate burden of cancer mortality, which may be partly due to their elevated tobacco use and limited receipt interventions rural healthcare settings. Here, we examine providers’ 5As (Ask, Advise, Assess, Assist, Arrange), brief cessation intervention, with patients assess intervention gaps. Methods: Provider practices substance treatment centers (SUTCs) medical (MHCs), each serving and/or medically underserved areas (MUAs) Texas, were compared. In total, 347 providers from 10 SUTCs (n = 174) 9 MHCs 173) responded an anonymized survey about cigarette non-cigarette screening delivery, along perceived importance workforce’s preparedness help stop using tobacco. Linear mixed generalized linear models used differences between at MHCs. Results: More MHC than SUTC reported that (respectively) important parts job (p 0.0009; p 0.0023) workforce was prepared quit 0.0275), although less half all respondents endorsed preparedness. Relative those SUTCs, higher rates asking (SUTCs 59.57% 77.21%; 0.0182) advising 45.34% 72.35%; 0.0017) smoking them products 43.94% 71.76%; 0.0016). Conclusions: Overall, both settings benefit greater preparation deliver care; needs more prevalent within Our findings can inform strategic planning improve centers’ capacity comprehensively address patients’ rural/MUAs US.

Язык: Английский

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